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Differential Site-Based Expression of Pentose Phosphate Pathway-Related Proteins among Breast Cancer Metastases

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dc.contributor.author구자승-
dc.contributor.author정우희-
dc.contributor.author차윤진-
dc.date.accessioned2017-11-02T08:12:49Z-
dc.date.available2017-11-02T08:12:49Z-
dc.date.issued2017-
dc.identifier.issn0278-0240-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/154206-
dc.description.abstractPurpose : We aimed to investigate the expression of pentose phosphate pathway- (PPP-) related proteins in metastatic breast cancer and its relationship with clinicopathologic factors. Methods : Tissue samples from 126 metastatic breast cancers were included in a tissue microarray. Expression of PPP-related proteins [glucose-6-phosphate dehydrogenase (G6PDH), 6-phosphogluconolactonase (6PGL), 6-phosphogluconate dehydrogenase (6PGDH), and nuclear factor erythroid 2-related factor (NRF2)] was determined by immunohistochemistry. Results. G6PDH (p = 0.011) and cytoplasmic NRF2 (p = 0.001) showed the highest expression in brain metastases. Human epidermal growth factor receptor (HER-2) positivity was associated with G6PDH (p < 0.001) and cytoplasmic NRF2 (p = 0.015) positivity. A high Ki-67 labeling index (LI) was correlated with nuclear NRF2 positivity (p = 0.037), and HER-2-positive luminal B type was associated with G6PDH positivity (p = 0.001). On multivariate Cox analysis, independent risk factors of short overall survival were 6PGL positivity in bone metastasis (HR 4.180, 95% CI 1.160-15.06, p = 0.029) and low Ki-67 LI in lung metastasis (HR 11.853, 95% CI 1.841-76.30, p = 0.009). Conclusion : Differential expression of PPP-related proteins correlated with different prognoses and metastatic sites, with the highest expression in brain metastases, and could be a potential therapeutic target.-
dc.description.statementOfResponsibilityopen-
dc.formatapplication/pdf-
dc.languageEnglish-
dc.publisherHindawi Pub. Corp.-
dc.relation.isPartOfDISEASE MARKERS-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAged-
dc.subject.MESHBone Neoplasms/secondary-
dc.subject.MESHBone and Bones/pathology-
dc.subject.MESHBrain Neoplasms/secondary-
dc.subject.MESHBreast Neoplasms/metabolism*-
dc.subject.MESHBreast Neoplasms/pathology*-
dc.subject.MESHCarboxylic Ester Hydrolases/metabolism-
dc.subject.MESHCarcinoma, Ductal, Breast/metabolism*-
dc.subject.MESHCytoplasm/metabolism-
dc.subject.MESHFemale-
dc.subject.MESHGene Expression Regulation, Neoplastic*-
dc.subject.MESHHumans-
dc.subject.MESHKi-67 Antigen/metabolism-
dc.subject.MESHLiver Neoplasms/secondary-
dc.subject.MESHLung Neoplasms/secondary-
dc.subject.MESHMiddle Aged-
dc.subject.MESHNF-E2-Related Factor 2/metabolism*-
dc.subject.MESHNeoplasm Metastasis-
dc.subject.MESHPentose Phosphate Pathway*-
dc.subject.MESHPhenotype-
dc.subject.MESHPhosphogluconate Dehydrogenase/metabolism-
dc.subject.MESHPrognosis-
dc.subject.MESHProportional Hazards Models-
dc.subject.MESHReceptor, ErbB-2/metabolism-
dc.subject.MESHRisk Factors-
dc.subject.MESHTissue Array Analysis-
dc.subject.MESHTreatment Outcome-
dc.titleDifferential Site-Based Expression of Pentose Phosphate Pathway-Related Proteins among Breast Cancer Metastases-
dc.typeArticle-
dc.publisher.locationUnited States-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Pathology-
dc.contributor.googleauthorYoon Jin Cha-
dc.contributor.googleauthorWoo Hee Jung-
dc.contributor.googleauthorJa Seung Koo-
dc.identifier.doi10.1155/2017/7062517-
dc.contributor.localIdA03671-
dc.contributor.localIdA04001-
dc.contributor.localIdA00198-
dc.relation.journalcodeJ00743-
dc.identifier.eissn1875-8630-
dc.identifier.pmid28260828-
dc.contributor.alternativeNameKoo, Ja Seung-
dc.contributor.alternativeNameJung, Woo Hee-
dc.contributor.alternativeNameCha, Yoon Jin-
dc.contributor.affiliatedAuthorJung, Woo Hee-
dc.contributor.affiliatedAuthorCha, Yoon Jin-
dc.contributor.affiliatedAuthorKoo, Ja Seung-
dc.contributor.affiliatedAuthor구자승-
dc.citation.titleDisease Markers-
dc.citation.volume2017-
dc.citation.startPage7062517-
dc.identifier.bibliographicCitationDISEASE MARKERS, Vol.2017 : 7062517, 2017-
dc.date.modified2017-11-01-
dc.identifier.rimsid42175-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers

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