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Subcortical 18 F-AV-1451 binding patterns in progressive supranuclear palsy

DC FieldValueLanguage
dc.contributor.author류철형-
dc.contributor.author유영훈-
dc.contributor.author이명식-
dc.contributor.author이승하-
dc.contributor.author조한나-
dc.contributor.author최재용-
dc.date.accessioned2017-11-02T08:12:03Z-
dc.date.available2017-11-02T08:12:03Z-
dc.date.issued2017-
dc.identifier.issn0885-3185-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/154191-
dc.description.abstractBACKGROUND: Accumulation of cortical and subcortical tau pathology is the primary pathological substrate for progressive supranuclear palsy (PSP). 18 F-AV-1451, a radiotracer that binds to the pathological tau protein, may be helpful for in vivo visualization and quantitation of tau pathology in PSP. OBJECTIVES: The objectives of this study were to investigate cortical and subcortical 18 F-AV-1451 binding patterns in patients with PSP. METHODS: We recruited 14 PSP patients and compared their cortical and subcortical binding patterns in 18 F-AV-1451 positron emission tomography (PET) studies with those of 15 Parkinson's disease (PD) patients and 15 healthy controls. RESULTS: In both the PD and PSP groups, subcortical 18 F-AV-1451 binding did not correlate with the severity of motor dysfunctions, and cortical binding did not differ between the controls and each patient group. However, the PSP patients showed greater 18 F-AV-1451 binding in the putamen, globus pallidus, subthalamic nucleus, and dentate nucleus when compared with the controls, whereas the PD patients showed lower 18 F-AV-1451 binding in the substantia nigra than controls. CONCLUSIONS: The PSP and PD patients showed distinct subcortical 18 F-AV-1451 binding patterns reflecting subcortical tau pathology in PSP and reduced nigral neuromelanin in PD. However, there was no correlation with the severity of motor dysfunction, no cortical regions with increased binding in PSP patients, and variable degrees of subcortical binding even in the controls. Therefore, the 18 F-AV-1451 PET may be less than ideal for assessing tau pathology in PSP. Further studies will be required to validate the clinical correlation and to understand the clinical utility of 18 F-AV-1451 PET for PSP patients. © 2016 International Parkinson and Movement Disorder Society.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherWiley-Liss-
dc.relation.isPartOfMovement Disorders-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAged-
dc.subject.MESHCarbolines*-
dc.subject.MESHCerebellar Nuclei/diagnostic imaging-
dc.subject.MESHCerebellar Nuclei/metabolism*-
dc.subject.MESHFemale-
dc.subject.MESHGlobus Pallidus/diagnostic imaging-
dc.subject.MESHGlobus Pallidus/metabolism*-
dc.subject.MESHHumans-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHParkinson Disease/diagnostic imaging-
dc.subject.MESHParkinson Disease/metabolism*-
dc.subject.MESHPositron-Emission Tomography/methods*-
dc.subject.MESHPutamen/diagnostic imaging-
dc.subject.MESHPutamen/metabolism*-
dc.subject.MESHSubthalamic Nucleus/diagnostic imaging-
dc.subject.MESHSubthalamic Nucleus/metabolism*-
dc.subject.MESHSupranuclear Palsy, Progressive/diagnostic imaging-
dc.subject.MESHSupranuclear Palsy, Progressive/metabolism*-
dc.subject.MESHtau Proteins/metabolism*-
dc.titleSubcortical 18 F-AV-1451 binding patterns in progressive supranuclear palsy-
dc.typeArticle-
dc.publisher.locationUnited States-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Neurology-
dc.contributor.googleauthorHanna Cho-
dc.contributor.googleauthorJae Yong Choi-
dc.contributor.googleauthorMi Song Hwang-
dc.contributor.googleauthorSeung Ha Lee-
dc.contributor.googleauthorYoung Hoon Ryu-
dc.contributor.googleauthorMyung Sik Lee-
dc.contributor.googleauthorChul Hyoung Lyoo-
dc.identifier.doi10.1002/mds.26844-
dc.contributor.localIdA02485-
dc.contributor.localIdA02753-
dc.contributor.localIdA04628-
dc.contributor.localIdA03920-
dc.contributor.localIdA04695-
dc.contributor.localIdA01333-
dc.relation.journalcodeJ02275-
dc.identifier.pmid27813160-
dc.identifier.urlhttp://onlinelibrary.wiley.com/doi/10.1002/mds.26844/abstract-
dc.subject.keyword18F-AV-1451-
dc.subject.keywordPET-
dc.subject.keywordParkinson's disease-
dc.subject.keywordProgressive supranuclear palsy-
dc.subject.keywordtau-
dc.contributor.alternativeNameLyoo, Chul Hyoung-
dc.contributor.alternativeNameRyu, Young Hoon-
dc.contributor.alternativeNameLee, Myung Sik-
dc.contributor.alternativeNameLee, Seung Ha-
dc.contributor.alternativeNameCho, Hanna-
dc.contributor.alternativeNameChoi, Jae Yong-
dc.contributor.affiliatedAuthorRyu, Young Hoon-
dc.contributor.affiliatedAuthorLee, Myung Sik-
dc.contributor.affiliatedAuthorLee, Seung Ha-
dc.contributor.affiliatedAuthorCho, Hanna-
dc.contributor.affiliatedAuthorChoi, Jae Yong-
dc.contributor.affiliatedAuthorLyoo, Chul Hyoung-
dc.citation.titleMovement Disorders-
dc.citation.volume32-
dc.citation.number1-
dc.citation.startPage134-
dc.citation.endPage140-
dc.identifier.bibliographicCitationMovement Disorders, Vol.32(1) : 134-140, 2017-
dc.date.modified2017-11-01-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Nuclear Medicine (핵의학교실) > 1. Journal Papers

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