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In vivo near-infrared imaging and phototherapy of tumors using a cathepsin B-activated fluorescent probe
DC Field | Value | Language |
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dc.contributor.author | 남기택 | - |
dc.contributor.author | 유성숙 | - |
dc.date.accessioned | 2017-11-02T08:12:01Z | - |
dc.date.available | 2017-11-02T08:12:01Z | - |
dc.date.issued | 2017 | - |
dc.identifier.issn | 0142-9612 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/154190 | - |
dc.description.abstract | The development of multifunctional reagents for simultaneous specific near-infrared (NIR) imaging and phototherapy of tumors is of great significance. This work describes the design of a cathepsin B-activated fluorescent probe (CyA-P-CyB) and its applications as an NIR imaging probe for tumor cells and as a phototherapy reagent for tumors. In vitro experiments demonstrated that CyA-P-CyB was activated via the cleavage of a peptide linker by cathepsin B in tumor cells to produce fluorescence in the NIR region based on a FRET mechanism. MTT assays showed that the phototoxicity of CyA-P-CyB toward cells depended on the activity of cathepsin B, and the probe exhibited specific phototoxicity toward tumor cells. CyA-P-CyB was also successfully applied to the in vivo imaging and phototherapy of tumors. Histological analysis indicated that CyA-P-CyB had no cytotoxic effects on seven mouse tissues (lung, liver, heart, kidney, pancreas, spleen and brain) after the CyA-P-CyB treatment and laser irradiation. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.publisher | Elsevier Science | - |
dc.relation.isPartOf | BIOMATERIALS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Cathepsin B | - |
dc.subject.MESH | Cell Line, Tumor | - |
dc.subject.MESH | Fluorescent Dyes/chemical synthesis | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Infrared Rays | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Mice | - |
dc.subject.MESH | Mice, Inbred BALB C | - |
dc.subject.MESH | Mice, Nude | - |
dc.subject.MESH | Microscopy, Fluorescence/methods* | - |
dc.subject.MESH | Neoplasms, Experimental/drug therapy* | - |
dc.subject.MESH | Neoplasms, Experimental/metabolism | - |
dc.subject.MESH | Neoplasms, Experimental/pathology* | - |
dc.subject.MESH | Oligopeptides/chemistry | - |
dc.subject.MESH | Oligopeptides/pharmacokinetics* | - |
dc.subject.MESH | Photochemotherapy/methods* | - |
dc.subject.MESH | Photosensitizing Agents/administration & dosage | - |
dc.subject.MESH | Theranostic Nanomedicine/methods* | - |
dc.subject.MESH | Treatment Outcome | - |
dc.title | In vivo near-infrared imaging and phototherapy of tumors using a cathepsin B-activated fluorescent probe | - |
dc.type | Article | - |
dc.publisher.location | Netherlands | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Life Science | - |
dc.contributor.googleauthor | Xiaoqiang Chen | - |
dc.contributor.googleauthor | Dayoung Lee | - |
dc.contributor.googleauthor | Sungsook Yu | - |
dc.contributor.googleauthor | Gyoungmi Kim | - |
dc.contributor.googleauthor | Songyi Lee | - |
dc.contributor.googleauthor | Yejin Cho | - |
dc.contributor.googleauthor | Haengdueng Jeong | - |
dc.contributor.googleauthor | Ki Taek Nam | - |
dc.contributor.googleauthor | Juyoung Yoon | - |
dc.identifier.doi | 10.1016/j.biomaterials.2017.01.020. | - |
dc.contributor.localId | A02473 | - |
dc.contributor.localId | A01243 | - |
dc.relation.journalcode | J00312 | - |
dc.identifier.eissn | 1878-5905 | - |
dc.identifier.pmid | 28113107 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S0142961217300285 | - |
dc.subject.keyword | Enzyme-activated fluorescence | - |
dc.subject.keyword | Multiple functional probe | - |
dc.subject.keyword | NIR bioimaging | - |
dc.subject.keyword | Specific phototherapy | - |
dc.contributor.alternativeName | Nam, Ki Taek | - |
dc.contributor.alternativeName | Yu, Sungsook | - |
dc.contributor.affiliatedAuthor | Yu, Sungsook | - |
dc.contributor.affiliatedAuthor | Nam, Ki Taek | - |
dc.citation.title | Biomaterials | - |
dc.citation.volume | 122 | - |
dc.citation.startPage | 130 | - |
dc.citation.endPage | 140 | - |
dc.identifier.bibliographicCitation | BIOMATERIALS, Vol.122 : 130-140, 2017 | - |
dc.date.modified | 2017-11-01 | - |
dc.identifier.rimsid | 42155 | - |
dc.type.rims | ART | - |
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