Cited 19 times in
A randomized, multicenter, phase III study of gemcitabine combined with capecitabine versus gemcitabine alone as first-line chemotherapy for advanced pancreatic cancer in South Korea.
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 박승우 | - |
dc.contributor.author | 방승민 | - |
dc.contributor.author | 송시영 | - |
dc.contributor.author | 이희승 | - |
dc.contributor.author | 정문재 | - |
dc.contributor.author | 박정엽 | - |
dc.date.accessioned | 2017-11-02T08:11:35Z | - |
dc.date.available | 2017-11-02T08:11:35Z | - |
dc.date.issued | 2017 | - |
dc.identifier.issn | 0025-7974 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/154182 | - |
dc.description.abstract | BACKGROUND: This phase III trial compared the efficacy and safety of gemcitabine plus capecitabine (GemCap) versus single-agent gemcitabine (Gem) in advanced pancreatic cancer as first-line chemotherapy. METHODS: A total of 214 advanced pancreatic cancer patients were enrolled from 16 hospitals in South Korea between 2007 and 2011. Patients were randomly assigned to receive GemCap (oral capecitabine 1660 mg/m plus Gem 1000 mg/m by 30-minute intravenous infusion weekly for 3 weeks followed by a 1-week break every 4 weeks) or Gem (by 30-minute intravenous infusion weekly for 3 weeks every 4 weeks). RESULTS: Median overall survival (OS) time, the primary end point, was 10.3 and 7.5 months in the GemCap and Gem arms, respectively (P = 0.06). Progression-free survival was 6.2 and 5.3 months in the GemCap and Gem arms, respectively (P = 0.08). GemCap significantly improved overall response rate compared with Gem alone (43.7% vs 17.6%; P = 0.001). Overall frequency of grade 3 or 4 toxicities was similar in each group. Neutropenia was the most frequent grade 3 or 4 toxicity in both groups. CONCLUSION: GemCap failed to improve OS at a statistically significant level compared to Gem treatment. This study showed a trend toward improved OS compared to Gem alone. GemCap and Gem both exhibited similar safety profiles. | - |
dc.description.statementOfResponsibility | open | - |
dc.format | application/pdf | - |
dc.language | English | - |
dc.publisher | Lippincott Williams & Wilkins | - |
dc.relation.isPartOf | MEDICINE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adenocarcinoma/drug therapy* | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Aged, 80 and over | - |
dc.subject.MESH | Antineoplastic Combined Chemotherapy Protocols/adverse effects | - |
dc.subject.MESH | Antineoplastic Combined Chemotherapy Protocols/therapeutic use* | - |
dc.subject.MESH | Capecitabine/administration & dosage | - |
dc.subject.MESH | Deoxycytidine/administration & dosage | - |
dc.subject.MESH | Deoxycytidine/adverse effects | - |
dc.subject.MESH | Deoxycytidine/analogs & derivatives* | - |
dc.subject.MESH | Deoxycytidine/therapeutic use | - |
dc.subject.MESH | Disease-Free Survival | - |
dc.subject.MESH | Female Humans | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Neutropenia/chemically induced | - |
dc.subject.MESH | Pancreatic Neoplasms/drug therapy* | - |
dc.subject.MESH | Republic of Korea | - |
dc.subject.MESH | Response Evaluation Criteria in Solid Tumors | - |
dc.subject.MESH | Survival Rate | - |
dc.title | A randomized, multicenter, phase III study of gemcitabine combined with capecitabine versus gemcitabine alone as first-line chemotherapy for advanced pancreatic cancer in South Korea. | - |
dc.type | Article | - |
dc.publisher.location | United States | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Internal Medicine | - |
dc.contributor.googleauthor | Hee Seung Lee | - |
dc.contributor.googleauthor | Moon Jae Chung | - |
dc.contributor.googleauthor | Jeong Youp Park | - |
dc.contributor.googleauthor | Seungmin Bang | - |
dc.contributor.googleauthor | Seung Woo Park | - |
dc.contributor.googleauthor | Ho Gak Kim | - |
dc.contributor.googleauthor | Myung Hwan Noh | - |
dc.contributor.googleauthor | Sang Hyub Lee | - |
dc.contributor.googleauthor | Yong-Tae Kim | - |
dc.contributor.googleauthor | Hyo Jung Kim | - |
dc.contributor.googleauthor | Chang Duck Kim | - |
dc.contributor.googleauthor | Dong Ki Lee | - |
dc.contributor.googleauthor | Kwang Bum Cho | - |
dc.contributor.googleauthor | Chang Min Cho | - |
dc.contributor.googleauthor | Jong Ho Moon | - |
dc.contributor.googleauthor | Dong Uk Kim | - |
dc.contributor.googleauthor | Dae Hwan Kang | - |
dc.contributor.googleauthor | Young Koog Cheon | - |
dc.contributor.googleauthor | Ho Soon Choi | - |
dc.contributor.googleauthor | Tae Hyeon Kim | - |
dc.contributor.googleauthor | Jae Kwang Kim | - |
dc.contributor.googleauthor | Jieun Moon | - |
dc.contributor.googleauthor | Hye Jung Shin | - |
dc.contributor.googleauthor | Si Young Song | - |
dc.identifier.doi | 10.1097/MD.0000000000005702 | - |
dc.contributor.localId | A01786 | - |
dc.contributor.localId | A02035 | - |
dc.contributor.localId | A03349 | - |
dc.contributor.localId | A03602 | - |
dc.contributor.localId | A01647 | - |
dc.contributor.localId | A01551 | - |
dc.relation.journalcode | J02214 | - |
dc.identifier.eissn | 1536-5964 | - |
dc.identifier.pmid | 28072706 | - |
dc.contributor.alternativeName | Park, Seung Woo | - |
dc.contributor.alternativeName | Bang, Seung Min | - |
dc.contributor.alternativeName | Song, Si Young | - |
dc.contributor.alternativeName | Lee, Hee Seung | - |
dc.contributor.alternativeName | Chung, Moon Jae | - |
dc.contributor.alternativeName | Park, Jeong Youp | - |
dc.contributor.affiliatedAuthor | Bang, Seung Min | - |
dc.contributor.affiliatedAuthor | Song, Si Young | - |
dc.contributor.affiliatedAuthor | Lee, Hee Seung | - |
dc.contributor.affiliatedAuthor | Chung, Moon Jae | - |
dc.contributor.affiliatedAuthor | Park, Jeong Youp | - |
dc.contributor.affiliatedAuthor | Park, Seung Woo | - |
dc.citation.title | Medicine | - |
dc.citation.volume | 96 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 5702 | - |
dc.identifier.bibliographicCitation | MEDICINE, Vol.96(1) : 5702, 2017 | - |
dc.date.modified | 2017-11-01 | - |
dc.identifier.rimsid | 42146 | - |
dc.type.rims | ART | - |
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