375 715

Cited 24 times in

The renal tubular damage marker urinary N-acetyl-β-D-glucosaminidase may be more closely associated with early detection of atherosclerosis than the glomerular damage marker albuminuria in patients with type 2 diabetes

DC Field Value Language
dc.contributor.author강은석-
dc.contributor.author김소라-
dc.contributor.author이병완-
dc.contributor.author이상국-
dc.contributor.author이용호-
dc.contributor.author차봉수-
dc.date.accessioned2017-11-02T08:11:18Z-
dc.date.available2017-11-02T08:11:18Z-
dc.date.issued2017-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/154177-
dc.description.abstractBACKGROUND: To determine the association between urinary N-acetyl-β-D-glucosaminidase (NAG), a marker of renal tubulopathy, and carotid intima-media thickness (IMT) and plaques in patients with type 2 diabetes mellitus (T2D) and to compare the predictive value of NAG versus albuminuria, a marker of renal glomerulopathy. METHODS: A total of 343 participants were enrolled in this retrospective cross-sectional study. We recruited participants with T2D who were tested for blood glucose parameters, urinary NAG, and urinary albumin-to-creatinine ratio (ACR) and had been checked for carotid ultrasonography. RESULTS: We classified participants into a below-median urinary NAG group (Group I; n = 172) or an above-median group (Group II; n = 171). Mean, maximum, and mean of maximum carotid IMT and the proportion of patients with carotid plaques were significantly higher in Group II compared with Group I. In multiple linear regression analyses, high urinary NAG (Group II) was significantly associated with carotid IMT, independently of urinary ACR and other confounding factors. In terms of carotid plaques, both urinary NAG and ACR were significantly higher in participants with carotid plaques than in those without carotid plaques. After adjustment for confounding factors, both urinary NAG and ACR were significantly associated with the presence of carotid plaques. CONCLUSIONS: Elevated urinary NAG, a marker of renal tubular damage, was related to increased carotid IMT and the presence of carotid plaques in patients with T2D. Urinary NAG may be a more sensitive biomarker than urinary albumin for early detection of atherosclerosis.-
dc.description.statementOfResponsibilityopen-
dc.formatapplication/pdf-
dc.languageEnglish-
dc.publisherBioMed Central-
dc.relation.isPartOfCARDIOVASCULAR DIABETOLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAcetylglucosaminidase/urine*-
dc.subject.MESHAged-
dc.subject.MESHAlbuminuria/diagnosis*-
dc.subject.MESHAlbuminuria/enzymology-
dc.subject.MESHBiomarkers/urine-
dc.subject.MESHCarotid Artery Diseases/diagnosis*-
dc.subject.MESHCarotid Artery Diseases/enzymology-
dc.subject.MESHCarotid Artery Diseases/urine-
dc.subject.MESHCarotid Intima-Media Thickness-
dc.subject.MESHChi-Square Distribution-
dc.subject.MESHCreatinine/urine-
dc.subject.MESHCross-Sectional Studies-
dc.subject.MESHDiabetes Mellitus, Type 2/diagnosis*-
dc.subject.MESHDiabetes Mellitus, Type 2/enzymology-
dc.subject.MESHDiabetes Mellitus, Type 2/urine-
dc.subject.MESHDiabetic Nephropathies/diagnosis*-
dc.subject.MESHDiabetic Nephropathies/enzymology-
dc.subject.MESHDiabetic Nephropathies/urine-
dc.subject.MESHEarly Diagnosis-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHKidney Tubules/enzymology*-
dc.subject.MESHLinear Models-
dc.subject.MESHLogistic Models-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHOdds Ratio-
dc.subject.MESHPlaque, Atherosclerotic-
dc.subject.MESHPredictive Value of Tests-
dc.subject.MESHRetrospective Studies-
dc.subject.MESHUrinalysis-
dc.titleThe renal tubular damage marker urinary N-acetyl-β-D-glucosaminidase may be more closely associated with early detection of atherosclerosis than the glomerular damage marker albuminuria in patients with type 2 diabetes-
dc.typeArticle-
dc.publisher.locationEngland-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Internal Medicine-
dc.contributor.googleauthorSo Ra Kim-
dc.contributor.googleauthorYong-ho Lee-
dc.contributor.googleauthorSang-Guk Lee-
dc.contributor.googleauthorEun Seok Kang-
dc.contributor.googleauthorBong-Soo Cha-
dc.contributor.googleauthorByung-Wan Lee-
dc.identifier.doi10.1186/s12933-017-0497-7-
dc.contributor.localIdA00612-
dc.contributor.localIdA02796-
dc.contributor.localIdA02810-
dc.contributor.localIdA02989-
dc.contributor.localIdA03996-
dc.contributor.localIdA00068-
dc.relation.journalcodeJ00460-
dc.identifier.eissn1475-2840-
dc.relation.journalsince2002~-
dc.identifier.pmid28122570-
dc.subject.keywordCarotid intima-media thickness-
dc.subject.keywordCarotid plaque-
dc.subject.keywordN-acetyl-β-D glucosaminidase-
dc.subject.keywordType 2 diabetes mellitus-
dc.contributor.alternativeNameKang, Eun Seok-
dc.contributor.alternativeNameKim, So Ra-
dc.contributor.alternativeNameLee, Byung Wan-
dc.contributor.alternativeNameLee, Sang Guk-
dc.contributor.alternativeNameLee, Yong Ho-
dc.contributor.alternativeNameCha, Bong Soo-
dc.contributor.affiliatedAuthorKim, So Ra-
dc.contributor.affiliatedAuthorLee, Byung Wan-
dc.contributor.affiliatedAuthorLee, Sang Guk-
dc.contributor.affiliatedAuthorLee, Yong Ho-
dc.contributor.affiliatedAuthorCha, Bong Soo-
dc.contributor.affiliatedAuthorKang, Eun Seok-
dc.citation.titleCardiovascular Diabetology-
dc.citation.volume16-
dc.citation.number1-
dc.citation.startPage16-
dc.identifier.bibliographicCitationCARDIOVASCULAR DIABETOLOGY, Vol.16(1) : 16, 2017-
dc.date.modified2017-11-01-
dc.identifier.rimsid42141-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Hospital Medicine (입원의학과) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.