Cited 18 times in
Serum adiponectin and protein-energy wasting in predialysis chronic kidney disease
DC Field | Value | Language |
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dc.contributor.author | 유태현 | - |
dc.contributor.author | 최규헌 | - |
dc.date.accessioned | 2017-11-02T08:11:16Z | - |
dc.date.available | 2017-11-02T08:11:16Z | - |
dc.date.issued | 2017 | - |
dc.identifier.issn | 0899-9007 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/154176 | - |
dc.description.abstract | OBJECTIVE: Adiponectin (ADPN) has antiatherogenic, anti-inflammatory, and insulin-sensitizing effects. Serum ADPN levels are increased in patients with chronic kidney diseases (CKD), and higher ADPN is paradoxically a predictor of mortality in these patients. The aim of this study was to determine the association between serum ADPN levels and protein-energy wasting (PEW) in predialysis CKD. METHOD: We examined serum ADPN concentrations and PEW in 1303 patients from the KNOW-CKD (KoreaN Cohort Study for Outcome in Patients With Chronic Kidney Disease) study. PEW was defined as the presence of three or more of the following four indicators: serum albumin <3.8 g/dL, body mass index <23 kg/m2, urine creatinine excretion (UCE) below the lower quartile, and daily dietary protein intake <0.6 g/kg. We analyzed the association between PEW and ADPN using a multivariate regression model after adjustment for socioeconomic factors, comorbidities, and laboratory findings. RESULTS: Among 1303 predialysis CKD patients, 72 (5.5%) had PEW. In multivariate logistic regression analysis, higher ADPN level was associated with PEW (odds ratio, 1.04; 95% confidence interval [CI], 1.01-1.08 by 1 μg/mL ADPN). The highest ADPN quartile was associated with PEW in comparison with the lowest quartile (odds ratio, 10.54; 95% CI, 1.28-86.74). In multiple linear regression with PEW indicators, ADPN was more strongly associated with UCE (β = -2.21; 95% CI, -4.13 to -0.28; R2 = 0.67). CONCLUSION: High ADPN is independently associated with PEW. Among PEW indicators, serum ADPN is closely associated with UCE as an indirect measure of muscle mass. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Elsevier Science | - |
dc.relation.isPartOf | NUTRITION | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adiponectin/blood* | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Biomarkers/blood | - |
dc.subject.MESH | Biomarkers/urine | - |
dc.subject.MESH | Cohort Studies | - |
dc.subject.MESH | Comorbidity | - |
dc.subject.MESH | Creatinine/urine | - |
dc.subject.MESH | Cross-Sectional Studies | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Hospitals, University | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Kidney/physiopathology | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Prevalence | - |
dc.subject.MESH | Prospective Studies | - |
dc.subject.MESH | Protein-Energy Malnutrition/epidemiology* | - |
dc.subject.MESH | Renal Insufficiency, Chronic/blood* | - |
dc.subject.MESH | Renal Insufficiency, Chronic/epidemiology | - |
dc.subject.MESH | Renal Insufficiency, Chronic/physiopathology | - |
dc.subject.MESH | Renal Insufficiency, Chronic/urine | - |
dc.subject.MESH | Republic of Korea/epidemiology | - |
dc.subject.MESH | Risk Factors | - |
dc.subject.MESH | Severity of Illness Index | - |
dc.subject.MESH | Up-Regulation* | - |
dc.title | Serum adiponectin and protein-energy wasting in predialysis chronic kidney disease | - |
dc.type | Article | - |
dc.publisher.location | United States | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Internal Medicine | - |
dc.contributor.googleauthor | Young Youl Hyun | - |
dc.contributor.googleauthor | Kyu-Beck Lee | - |
dc.contributor.googleauthor | Kook-Hwan Oh | - |
dc.contributor.googleauthor | Curie Ahn | - |
dc.contributor.googleauthor | Sue Kyung Park | - |
dc.contributor.googleauthor | Dong Wan Chae | - |
dc.contributor.googleauthor | Tae-Hyun Yoo | - |
dc.contributor.googleauthor | Kyu Hun Cho | - |
dc.contributor.googleauthor | Yong-Soo Kim | - |
dc.contributor.googleauthor | Young-Hwan Hwang | - |
dc.contributor.googleauthor | Representing KNOW-CKD Study Group | - |
dc.identifier.doi | 10.1016/j.nut.2016.06.014 | - |
dc.contributor.localId | A04043 | - |
dc.contributor.localId | A02526 | - |
dc.relation.journalcode | J02397 | - |
dc.identifier.eissn | 1873-1244 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S0899900716301320 | - |
dc.subject.keyword | Adiponectin | - |
dc.subject.keyword | Chronic kidney disease | - |
dc.subject.keyword | Protein–energy wasting | - |
dc.subject.keyword | Urine creatinine excretion | - |
dc.contributor.alternativeName | Yoo, Tae Hyun | - |
dc.contributor.alternativeName | Choi, Kyu Hun | - |
dc.contributor.affiliatedAuthor | Choi, Kyu Hun | - |
dc.contributor.affiliatedAuthor | Yoo, Tae Hyun | - |
dc.citation.title | Nutrition | - |
dc.citation.volume | 33 | - |
dc.citation.startPage | 254 | - |
dc.citation.endPage | 260 | - |
dc.identifier.bibliographicCitation | NUTRITION, Vol.33 : 254-260, 2017 | - |
dc.date.modified | 2017-11-01 | - |
dc.identifier.rimsid | 42140 | - |
dc.type.rims | ART | - |
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