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Obesity is more closely related with hepatic steatosis and fibrosis measured by transient elastography than metabolic health status

DC Field Value Language
dc.contributor.author김승업-
dc.contributor.author이병완-
dc.contributor.author차봉수-
dc.contributor.author한광협-
dc.contributor.author한승환-
dc.contributor.author김광준-
dc.date.accessioned2017-11-02T08:10:18Z-
dc.date.available2017-11-02T08:10:18Z-
dc.date.issued2017-
dc.identifier.issn0026-0495-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/154159-
dc.description.abstractOBJECTIVE: The pathogenesis of non-alcoholic fatty liver disease (NAFLD) involves multiple concomitant events induced by obesity and metabolic health condition. This study aimed to assess the risk of NAFLD according to metabolic health and obesity status using transient elastography (TE). MATERIALS AND METHODS: A total of 2198 asymptomatic adults without chronic liver disease and who underwent a medical health check-up were recruited. Subjects were categorized into four groups according to metabolic health and obesity statuses: metabolically healthy non-obese (MHNO); metabolically unhealthy non-obese (MUNO); metabolically healthy obese (MHO); and metabolically unhealthy obese (MUO). Hepatic steatosis was defined as controlled attenuation parameter (CAP)≥238dB/m, and significant liver fibrosis was defined as liver stiffness measurement (LSM) >7.0kPa, as defined by TE. RESULTS: Compared with MHNO group, the odds ratios (ORs) [95% confidence interval (CI)] for hepatic steatosis were 2.94 [2.32-3.71], 4.62 [3.52-6.07], and 12.02 [9.08-15.92] in the MUNO, MHO, and MUO groups, respectively (P<0.001) in crude model. Regarding liver fibrosis, there was no significant difference in the ORs in MUNO group (ORs: 0.95 [95% CI, 0.33-2.78], P value = 0.929), whereas there was a significant increase in the ORs in MHO group compared with MHNO group (ORs: 4.32 [95% CI, 1.73-10.76], P=0.002) in the fully adjusted model. CONCLUSION: Our results show that MHO was associated with both liver steatosis and fibrosis assessed by transient elastography. Our results suggest that a healthy metabolic profile does not protect obese adults from hepatic steatosis or fibrosis, indicating that obesity itself might contribute to liver fibrosis.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherW.B. Saunders-
dc.relation.isPartOfMETABOLISM-CLINICAL AND EXPERIMENTAL-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHComorbidity-
dc.subject.MESHElasticity Imaging Techniques-
dc.subject.MESHFemale-
dc.subject.MESHHealth Status-
dc.subject.MESHHumans-
dc.subject.MESHLiver/diagnostic imaging-
dc.subject.MESHLiver/pathology-
dc.subject.MESHLiver Cirrhosis/complications*-
dc.subject.MESHLiver Cirrhosis/diagnostic imaging-
dc.subject.MESHLiver Cirrhosis/epidemiology-
dc.subject.MESHMale-
dc.subject.MESHMetabolic Syndrome/complications*-
dc.subject.MESHMetabolic Syndrome/diagnostic imaging-
dc.subject.MESHMetabolic Syndrome/epidemiology-
dc.subject.MESHMiddle Aged-
dc.subject.MESHNon-alcoholic Fatty Liver Disease/complications*-
dc.subject.MESHNon-alcoholic Fatty Liver Disease/diagnostic imaging-
dc.subject.MESHNon-alcoholic Fatty Liver Disease/epidemiology-
dc.subject.MESHObesity/complications*-
dc.subject.MESHObesity/diagnostic imaging-
dc.subject.MESHObesity/epidemiology-
dc.subject.MESHObesity/metabolism*-
dc.subject.MESHObesity, Metabolically Benign/complications*-
dc.subject.MESHObesity, Metabolically Benign/diagnostic imaging-
dc.subject.MESHObesity, Metabolically Benign/epidemiology-
dc.titleObesity is more closely related with hepatic steatosis and fibrosis measured by transient elastography than metabolic health status-
dc.typeArticle-
dc.publisher.locationUnited States-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Internal Medicine-
dc.contributor.googleauthorJi Hye Huh-
dc.contributor.googleauthorKwang Joon Kim-
dc.contributor.googleauthorSeung Up Kim-
dc.contributor.googleauthorSeung Hwan Han-
dc.contributor.googleauthorKwang-Hyub Han-
dc.contributor.googleauthorBong-Soo Cha-
dc.contributor.googleauthorChoon Hee Chung-
dc.contributor.googleauthorByung-Wan Lee-
dc.identifier.doi10.1016/j.metabol.2016.10.003-
dc.contributor.localIdA00317-
dc.contributor.localIdA02796-
dc.contributor.localIdA03996-
dc.contributor.localIdA04268-
dc.contributor.localIdA04305-
dc.contributor.localIdA00654-
dc.relation.journalcodeJ02223-
dc.identifier.eissn1532-8600-
dc.identifier.pmid27923446-
dc.identifier.urlhttp://www.sciencedirect.com/science/article/pii/S0026049516301287-
dc.subject.keywordLiver fibrosis-
dc.subject.keywordMetabolically healthy obese-
dc.subject.keywordNon-alcoholic fatty liver disease-
dc.subject.keywordTransient elastography-
dc.contributor.alternativeNameKim, Seung Up-
dc.contributor.alternativeNameLee, Byung Wan-
dc.contributor.alternativeNameCha, Bong Soo-
dc.contributor.alternativeNameHan, Kwang Hyup-
dc.contributor.alternativeNameHan, Seung Hwan-
dc.contributor.affiliatedAuthorKim, Kwang Joon-
dc.contributor.affiliatedAuthorLee, Byung Wan-
dc.contributor.affiliatedAuthorCha, Bong Soo-
dc.contributor.affiliatedAuthorHan, Kwang Hyup-
dc.contributor.affiliatedAuthorHan, Seung Hwan-
dc.contributor.affiliatedAuthorKim, Seung Up-
dc.citation.titleMetabolism: Clinical and Experimental-
dc.citation.volume66-
dc.citation.startPage23-
dc.citation.endPage31-
dc.identifier.bibliographicCitationMETABOLISM-CLINICAL AND EXPERIMENTAL, Vol.66 : 23-31, 2017-
dc.date.modified2017-11-01-
dc.identifier.rimsid42121-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Orthopedic Surgery (정형외과학교실) > 1. Journal Papers

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