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Volumetric analysis of the cerebellum in patients with progressive supranuclear palsy

DC Field Value Language
dc.contributor.author손영호-
dc.contributor.author이윤주-
dc.contributor.author이필휴-
dc.contributor.author정수진-
dc.date.accessioned2017-11-02T08:10:09Z-
dc.date.available2017-11-02T08:10:09Z-
dc.date.issued2017-
dc.identifier.issn1351-5101-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/154157-
dc.description.abstractBACKGROUND AND PURPOSE: Although early cerebellar symptoms are one of the exclusive criteria in the diagnosis of progressive supranuclear palsy (PSP), cerebellar involvement in PSP is evident both clinically and pathologically. However, structural analysis focusing on the cerebellum has not been previously studied in patients with PSP. We aimed to evaluate cerebellar involvement in PSP using a magnetic resonance imaging-based segmental volumetric analysis. METHODS: We retrospectively enrolled 48 patients with PSP composed of 25 patients with PSP-Richardson's syndrome (RS) and 23 patients with pure akinesia with gait freezing, 39 patients with Parkinson's disease (PD) and 34 healthy controls. Data on both the whole and segmented cerebellar volumes were analyzed using a fully automated procedure. RESULTS: A general linear model showed that whole cerebellar volume in patients with PSP was significantly smaller compared with that of patients with PD or controls after controlling for age, sex and intracranial volume (P = 0.34). In addition, patients with PSP exhibited decreased regional volume in the crus I, lobule VIIIa and lobule VIIIb, which play roles as secondary representations of motor tasks, compared with patients with PD or controls. In subgroup analysis of PSP, volume loss in the whole and segmental cerebellum was more pronounced in patients with PSP-RS than in those with pure akinesia with gait freezing, PD or control subjects. CONCLUSION: These data demonstrate that cerebellar atrophy is evident in patients with PSP and is especially prominent in the PSP-RS group. These findings increase understanding of the clinicopathological basis of cerebellar involvement in PSP.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherWiley-
dc.relation.isPartOfEUROPEAN JOURNAL OF NEUROLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAged-
dc.subject.MESHCerebellum/diagnostic imaging-
dc.subject.MESHCerebellum/pathology*-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHMagnetic Resonance Imaging-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHOrgan Size/physiology-
dc.subject.MESHParkinson Disease/diagnostic imaging-
dc.subject.MESHParkinson Disease/pathology-
dc.subject.MESHRetrospective Studies-
dc.subject.MESHSupranuclear Palsy, Progressive/diagnostic imaging-
dc.subject.MESHSupranuclear Palsy, Progressive/pathology*-
dc.titleVolumetric analysis of the cerebellum in patients with progressive supranuclear palsy-
dc.typeArticle-
dc.publisher.locationEngland-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Neurology-
dc.contributor.googleauthorY. Lee-
dc.contributor.googleauthorD. K. Lee-
dc.contributor.googleauthorJ. M. Lee-
dc.contributor.googleauthorS. J. Chung-
dc.contributor.googleauthorJ. J. Lee-
dc.contributor.googleauthorY. H. Sohn-
dc.contributor.googleauthorP. H. Lee-
dc.identifier.doi10.1111/ene.13185-
dc.contributor.localIdA03024-
dc.contributor.localIdA03270-
dc.contributor.localIdA04668-
dc.contributor.localIdA01982-
dc.relation.journalcodeJ00830-
dc.identifier.eissn1468-1331-
dc.identifier.pmid27747983-
dc.identifier.urlhttp://onlinelibrary.wiley.com/doi/10.1111/ene.13185/abstract-
dc.subject.keywordatrophy-
dc.subject.keywordcerebellum-
dc.subject.keywordprogressive supranuclear palsy-
dc.subject.keywordvolumetry-
dc.contributor.alternativeNameSohn, Young Ho-
dc.contributor.alternativeNameLee, Yoon Ju-
dc.contributor.alternativeNameLee, Phil Hyu-
dc.contributor.alternativeNameChung, Su Jin-
dc.contributor.affiliatedAuthorLee, Yoon Ju-
dc.contributor.affiliatedAuthorLee, Phil Hyu-
dc.contributor.affiliatedAuthorChung, Su Jin-
dc.contributor.affiliatedAuthorSohn, Young Ho-
dc.citation.titleEuropean Journal of Neurology-
dc.citation.volume24-
dc.citation.number1-
dc.citation.startPage212-
dc.citation.endPage218-
dc.identifier.bibliographicCitationEUROPEAN JOURNAL OF NEUROLOGY, Vol.24(1) : 212-218, 2017-
dc.date.modified2017-11-01-
dc.identifier.rimsid42119-
dc.type.rimsART-
Appears in Collections:
6. Others (기타) > Dept. of Health Promotion (건강의학과) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers

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