Cited 29 times in
Tumor-associated mesenchymal stem-like cells provide extracellular signaling cue for invasiveness of glioblastoma cells
DC Field | Value | Language |
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dc.contributor.author | 강석구 | - |
dc.contributor.author | 장종희 | - |
dc.contributor.author | 이지현 | - |
dc.date.accessioned | 2017-11-02T08:06:24Z | - |
dc.date.available | 2017-11-02T08:06:24Z | - |
dc.date.issued | 2017 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/154084 | - |
dc.description.abstract | Hyaluronic acid (HA) is abundant in tumor microenvironment and closely associated with invasiveness of glioblastoma (GBM) cells. However, the cellular mechanism underlying HA-rich microenvironment in GBM remains unexplored. Here, we show that tumor-associated mesenchymal stem-like cells (tMSLCs) contribute to abundance of hyaluronic acid (HA) in tumor microenvironment through HA synthase-2 (HAS2) induction, and thereby enhances invasiveness of GBM cells. In an autocrine manner, C5a secreted by tMSLCs activated ERK MAPK for HAS2 induction in tMSLCs. Importantly, HA acted as a signaling ligand of its cognate receptor RHAMM for intracellular signaling activation underlying invasiveness of GBM cells. Taken together, our study suggests that tMSLCs contribute to HA-rich proinvasive ECM microenvironment in GBM. | - |
dc.description.statementOfResponsibility | open | - |
dc.format | application/pdf | - |
dc.language | English | - |
dc.publisher | Impact Journals | - |
dc.relation.isPartOf | ONCOTARGET | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Brain Neoplasms/metabolism* | - |
dc.subject.MESH | Brain Neoplasms/pathology | - |
dc.subject.MESH | Extracellular Matrix Proteins/metabolism | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Glioblastoma/metabolism* | - |
dc.subject.MESH | Glioblastoma/pathology | - |
dc.subject.MESH | Heterografts | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Hyaluronan Receptors/metabolism | - |
dc.subject.MESH | Hyaluronic Acid/pharmacology | - |
dc.subject.MESH | Ligands | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Mesenchymal Stromal Cells/metabolism* | - |
dc.subject.MESH | Mesenchymal Stromal Cells/pathology | - |
dc.subject.MESH | Mice | - |
dc.subject.MESH | Mice, Nude | - |
dc.subject.MESH | Neoplasm Invasiveness | - |
dc.subject.MESH | Signal Transduction | - |
dc.title | Tumor-associated mesenchymal stem-like cells provide extracellular signaling cue for invasiveness of glioblastoma cells | - |
dc.type | Article | - |
dc.publisher.location | United States | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Neurosurgery | - |
dc.contributor.googleauthor | Eun-Jung Lim | - |
dc.contributor.googleauthor | Yongjoon Suh | - |
dc.contributor.googleauthor | Ki-Chun Yoo | - |
dc.contributor.googleauthor | Ji-Hyun Lee | - |
dc.contributor.googleauthor | In-Gyu Kim | - |
dc.contributor.googleauthor | Min-Jung Kim | - |
dc.contributor.googleauthor | Jong Hee Chang | - |
dc.contributor.googleauthor | Seok-Gu Kang | - |
dc.contributor.googleauthor | Su-Jae Lee | - |
dc.identifier.doi | 10.18632/oncotarget.13638 | - |
dc.contributor.localId | A03470 | - |
dc.contributor.localId | A03218 | - |
dc.contributor.localId | A00036 | - |
dc.relation.journalcode | J02421 | - |
dc.identifier.eissn | 1949-2553 | - |
dc.identifier.pmid | 27903965 | - |
dc.subject.keyword | C5a | - |
dc.subject.keyword | extracellular matrix remodeling | - |
dc.subject.keyword | hyaluronic acid | - |
dc.subject.keyword | hyaluronic acid synthase-2 | - |
dc.subject.keyword | mesenchymal stem-like cells | - |
dc.contributor.alternativeName | Kang, Seok Gu | - |
dc.contributor.alternativeName | Chang, Jong Hee | - |
dc.contributor.affiliatedAuthor | Chang, Jong Hee | - |
dc.contributor.affiliatedAuthor | Lee, Ji Hyun | - |
dc.contributor.affiliatedAuthor | Kang, Seok Gu | - |
dc.citation.title | Oncotarget | - |
dc.citation.volume | 8 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 1438 | - |
dc.citation.endPage | 1448 | - |
dc.identifier.bibliographicCitation | ONCOTARGET , Vol.8(1) : 1438-1448, 2017 | - |
dc.date.modified | 2017-11-01 | - |
dc.identifier.rimsid | 41578 | - |
dc.type.rims | ART | - |
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