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A combined prognostic factor for improved risk stratification of patients with oral cancer

DC FieldValueLanguage
dc.contributor.author차인호-
dc.contributor.author김기열-
dc.contributor.author장향란-
dc.date.accessioned2017-11-02T08:06:11Z-
dc.date.available2017-11-02T08:06:11Z-
dc.date.issued2017-
dc.identifier.issn1354-523X-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/154079-
dc.description.abstractPURPOSE: We aimed to identify a combined prognostic factor for predicting better performance in risk stratification. MATERIALS AND METHODS: We reviewed the clinical and pathological variables of 316 patients with oral squamous cell carcinoma (OSCC) who underwent surgery. To identify a combined predictor, principal component analysis (PCA) was performed. RESULTS: Univariate analysis showed that the independent prognostic variables for overall survival (OS) were pathologic T stage (T1 vs T4, HR = 1.99, 95% CI: = 1.083-3.675, P = 0.026) and pathologic N stage (N0 vs N2, HR=1.90, 95% CI: = 1.17-3.08, P = 0.008). In the multivariate analysis, only pathologic T stage was significant (P = 0.006 and P = 0.007); however, the multivariate model was not significant (P = 0.191). The multivariate model became significant by including lymph node ratio (LNR) instead of pathologic N stage (P = 0.0025 in numeric LNR, P = 0.0007 in categorized LNR). Also, the performance of prediction model was improved by a combined prognostic factor (P = 0.0002). CONCLUSIONS: The newly identified combined prognostic factor included resection margin, differentiation, and LNR, and they were insignificant factors independently except for LNR. This combined prognostic factor showed a good performance although it did not include molecular markers; therefore, it may be used conveniently for risk stratification of patients with OSCC by combining only clinical information.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherMunksgaard-
dc.relation.isPartOfORAL DISEASES-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHAged, 80 and over-
dc.subject.MESHCarcinoma, Squamous Cell/diagnosis*-
dc.subject.MESHCarcinoma, Squamous Cell/mortality-
dc.subject.MESHCarcinoma, Squamous Cell/pathology-
dc.subject.MESHCarcinoma, Squamous Cell/surgery-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHMouth Neoplasms/diagnosis*-
dc.subject.MESHMouth Neoplasms/mortality-
dc.subject.MESHMouth Neoplasms/pathology-
dc.subject.MESHMouth Neoplasms/surgery-
dc.subject.MESHNeoplasm Staging-
dc.subject.MESHPrincipal Component Analysis-
dc.subject.MESHPrognosis-
dc.subject.MESHRetrospective Studies-
dc.subject.MESHRisk Assessment/methods-
dc.subject.MESHSurvival Analysis-
dc.subject.MESHYoung Adult-
dc.titleA combined prognostic factor for improved risk stratification of patients with oral cancer-
dc.typeArticle-
dc.publisher.locationDenmark-
dc.contributor.collegeCollege of Dentistry-
dc.contributor.departmentDept. of Oral and Maxillofacial Surgery-
dc.contributor.googleauthorK-Y Kim-
dc.contributor.googleauthorX Zhang-
dc.contributor.googleauthorS-M Kim-
dc.contributor.googleauthorB-D Lee-
dc.contributor.googleauthorI-H Cha-
dc.identifier.doi10.1111/odi.12579-
dc.contributor.localIdA00337-
dc.contributor.localIdA03489-
dc.contributor.localIdA04002-
dc.relation.journalcodeJ02438-
dc.identifier.eissn1601-0825-
dc.identifier.pmid27588367-
dc.identifier.urlhttp://onlinelibrary.wiley.com/doi/10.1111/odi.12579/abstract-
dc.subject.keywordclinical diagnosis-
dc.subject.keywordcombined prognostic factor-
dc.subject.keywordlymph node ratio-
dc.subject.keywordoral cancer-
dc.subject.keywordrisk stratification-
dc.contributor.alternativeNameCha, In Ho-
dc.contributor.alternativeNameKim, Ki Yeol-
dc.contributor.alternativeNameZhang, Xiang Lan-
dc.contributor.affiliatedAuthorKim, Ki Yeol-
dc.contributor.affiliatedAuthorZhang, Xiang Lan-
dc.contributor.affiliatedAuthorCha, In Ho-
dc.citation.titleOral Diseases-
dc.citation.volume23-
dc.citation.number1-
dc.citation.startPage91-
dc.citation.endPage96-
dc.identifier.bibliographicCitationORAL DISEASES, Vol.23(1) : 91-96, 2017-
dc.date.modified2017-11-01-
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Oral and Maxillofacial Surgery (구강악안면외과학교실) > 1. Journal Papers
5. Research Institutes (연구소) > Oral Cancer Research Institute (구강종양연구소) > 1. Journal Papers

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