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Impact of Including Peritumoral Edema in Radiotherapy Target Volume on Patterns of Failure in Glioblastoma following Temozolomide-based Chemoradiotherapy

DC FieldValueLanguage
dc.contributor.author김세훈-
dc.contributor.author김준원-
dc.contributor.author서창옥-
dc.contributor.author장종희-
dc.contributor.author장지석-
dc.contributor.author조재호-
dc.contributor.author최서희-
dc.date.accessioned2017-11-01T09:02:49Z-
dc.date.available2017-11-01T09:02:49Z-
dc.date.issued2017-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/153954-
dc.description.abstractWe assessed the impact of including peritumoral edema in radiotherapy volumes on recurrence patterns among glioblastoma multiforme (GBM) patients treated with standard chemoradiotherapy (CRT). We analyzed 167 patients with histologically confirmed GBM who received temozolomide (TMZ)-based CRT between May 2006 and November 2012. The study cohort was divided into edema (+) (n = 130) and edema (-) (n = 37) groups, according to whether the entire peritumoral edema was included. At a median follow-up of 20 months (range, 2-99 months), 118 patients (71%) experienced progression/recurrence (infield: 69%; marginal: 26%; outfield: 16%; CSF seeding: 12%). The median overall survival and progression-free survival were 20 months and 15 months, respectively. The marginal failure rate was significantly greater in the edema (-) group (37% vs. 22%, p = 0.050). Among 33 patients who had a favorable prognosis (total resection and MGMT-methylation), the difference in the marginal failure rates was increased (40% vs. 14%, p = 0.138). Meanwhile, treatment of edema did not significantly increase the incidence of pseudoprogression/radiation necrosis (edema (-) 49% vs. (+) 37%, p = 0.253). Inclusion of peritumoral edema in the radiotherapy volume can reduce marginal failures following TMZ-based CRT without increasing pseudoprogression/radiation necrosis.-
dc.description.statementOfResponsibilityopen-
dc.formatapplication/pdf-
dc.languageEnglish-
dc.publisherNature Publishing Group-
dc.relation.isPartOfSCIENTIFIC REPORTS-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleImpact of Including Peritumoral Edema in Radiotherapy Target Volume on Patterns of Failure in Glioblastoma following Temozolomide-based Chemoradiotherapy-
dc.typeArticle-
dc.publisher.locationEngland-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Pathology-
dc.contributor.googleauthorSeo Hee Choi-
dc.contributor.googleauthorJun Won Kim-
dc.contributor.googleauthorJee Suk Chang-
dc.contributor.googleauthorJae Ho Cho-
dc.contributor.googleauthorSe Hoon Kim-
dc.contributor.googleauthorJong Hee Chang-
dc.contributor.googleauthorChang-Ok Suh-
dc.identifier.doi10.1038/srep42148-
dc.contributor.localIdA00958-
dc.contributor.localIdA01919-
dc.contributor.localIdA03470-
dc.contributor.localIdA04658-
dc.contributor.localIdA03901-
dc.contributor.localIdA04867-
dc.contributor.localIdA00610-
dc.relation.journalcodeJ02646-
dc.identifier.eissn2045-2322-
dc.identifier.pmid28176884-
dc.contributor.alternativeNameKim, Se Hoon-
dc.contributor.alternativeNameKim, Jun Won-
dc.contributor.alternativeNameSuh, Chang Ok-
dc.contributor.alternativeNameChang, Jong Hee-
dc.contributor.alternativeNameChang, Jee Suk Paul-
dc.contributor.alternativeNameCho, Jae Ho-
dc.contributor.alternativeNameChoi, Seo Hee-
dc.contributor.affiliatedAuthorKim, Jun Won-
dc.contributor.affiliatedAuthorSuh, Chang Ok-
dc.contributor.affiliatedAuthorChang, Jong Hee-
dc.contributor.affiliatedAuthorChang, Jee Suk Paul-
dc.contributor.affiliatedAuthorCho, Jae Ho-
dc.contributor.affiliatedAuthorChoi, Seo Hee-
dc.contributor.affiliatedAuthorKim, Se Hoon-
dc.citation.titleScientific Reports-
dc.citation.volume7-
dc.citation.startPage42148-
dc.identifier.bibliographicCitationSCIENTIFIC REPORTS, Vol.7 : 42148, 2017-
dc.date.modified2017-11-01-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiation Oncology (방사선종양학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Neurosurgery (신경외과학교실) > 1. Journal Papers

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