Cited 14 times in
BRCA1 and BRCA2 mutation predictions using the BRCAPRO and Myriad models in Korean ovarian cancer patients
DC Field | Value | Language |
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dc.contributor.author | 김상운 | - |
dc.contributor.author | 김성훈 | - |
dc.contributor.author | 김영태 | - |
dc.contributor.author | 남은지 | - |
dc.contributor.author | 박형석 | - |
dc.contributor.author | 어경진 | - |
dc.contributor.author | 이승태 | - |
dc.contributor.author | 이정윤 | - |
dc.contributor.author | 한정우 | - |
dc.contributor.author | 박지수 | - |
dc.date.accessioned | 2017-11-01T08:59:12Z | - |
dc.date.available | 2017-11-01T08:59:12Z | - |
dc.date.issued | 2017 | - |
dc.identifier.issn | 0090-8258 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/153877 | - |
dc.description.abstract | OBJECTIVE: To evaluate the predictive efficacies including sensitivity and positive predictive value of the genetic risk prediction model BRCAPRO and the Myriad BRCA risk calculator in Korean ovarian cancer patients. METHODS: Individuals undergoing genetic testing for BRCA mutations from November 2010-August 2016 were recruited from the Department of Obstetrics and Gynecology at a single institute in Korea. The observed BRCA1 and BRCA2 mutation statuses were compared with the predicted carrier probabilities using BRCAPRO and the Myriad BRCA risk calculator. RESULTS: Two hundred thirty-two patients were recruited, of whom 99.1% (230/232) were of Korean ethnicity. Of the 232 individuals, 206 and 26 had ovarian and double primary breast/ovarian cancer, respectively. Thirty-six individuals had a family history of breast/ovarian cancer in first-degree relatives. Fifty-seven patients (24.6%) tested positive for BRCA mutation (41 BRCA1, 16 BRCA2). The mean BRCAPRO and Myriad scores for all patients were 6.4% and 7.7%, respectively. The scores were significantly higher for patients with positive BRCA mutation status (29.0% vs. 6.1%, P<0.001, 12.1% vs. 7.7%, P<0.001, respectively). For all patients, the respective areas under the receiver operating characteristics curves were 0.720 and 0.747 for the BRCAPRO and Myriad models to predict the risk of carrying a BRCA mutation. Both models overestimated the mutation probability in patients with a family history of breast/ovarian cancer (1.55-fold and 1.50-fold, respectively) and underestimated the probability in patients without a family history (both, 0.54-fold). CONCLUSION: BRCAPRO and Myriad seem to be acceptable risk assessment tools for determining the risk of carrying BRCA mutations in Korean ovarian cancer patients. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Academic Press | - |
dc.relation.isPartOf | GYNECOLOGIC ONCOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adenocarcinoma, Clear Cell/genetics* | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Aged, 80 and over | - |
dc.subject.MESH | Asian Continental Ancestry Group/genetics* | - |
dc.subject.MESH | Breast Neoplasms/genetics | - |
dc.subject.MESH | Carcinoma, Endometrioid/genetics* | - |
dc.subject.MESH | Decision Support Techniques | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Genes, BRCA1* | - |
dc.subject.MESH | Genes, BRCA2* | - |
dc.subject.MESH | Genetic Predisposition to Disease | - |
dc.subject.MESH | Genetic Testing | - |
dc.subject.MESH | Hereditary Breast and Ovarian Cancer Syndrome/diagnosis | - |
dc.subject.MESH | Hereditary Breast and Ovarian Cancer Syndrome/epidemiology | - |
dc.subject.MESH | Hereditary Breast and Ovarian Cancer Syndrome/genetics* | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Models, Theoretical | - |
dc.subject.MESH | Mutation* | - |
dc.subject.MESH | Neoplasms, Cystic, Mucinous, and Serous/genetics* | - |
dc.subject.MESH | Ovarian Neoplasms/genetics* | - |
dc.subject.MESH | Probability | - |
dc.subject.MESH | ROC Curve | - |
dc.subject.MESH | Republic of Korea | - |
dc.subject.MESH | Risk Assessment | - |
dc.title | BRCA1 and BRCA2 mutation predictions using the BRCAPRO and Myriad models in Korean ovarian cancer patients | - |
dc.type | Article | - |
dc.publisher.location | United States | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Obstetrics & Gynecology | - |
dc.contributor.googleauthor | Kyung Jin Eoh | - |
dc.contributor.googleauthor | Ji Soo Park | - |
dc.contributor.googleauthor | Hyung Seok Park | - |
dc.contributor.googleauthor | Seung-Tae Lee | - |
dc.contributor.googleauthor | Jeongwoo Han | - |
dc.contributor.googleauthor | Jung-Yun Lee | - |
dc.contributor.googleauthor | Sang Wun Kim | - |
dc.contributor.googleauthor | Sunghoon Kim | - |
dc.contributor.googleauthor | Young Tae Kim | - |
dc.contributor.googleauthor | Eun Ji Nam | - |
dc.identifier.doi | 10.1016/j.ygyno.2017.01.026 | - |
dc.contributor.localId | A00595 | - |
dc.contributor.localId | A00729 | - |
dc.contributor.localId | A01262 | - |
dc.contributor.localId | A01753 | - |
dc.contributor.localId | A04842 | - |
dc.contributor.localId | A04627 | - |
dc.contributor.localId | A04638 | - |
dc.contributor.localId | A04325 | - |
dc.contributor.localId | A00526 | - |
dc.relation.journalcode | J00956 | - |
dc.identifier.eissn | 1095-6859 | - |
dc.identifier.pmid | 28159408 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S0090825817300707 | - |
dc.subject.keyword | BRCA1 | - |
dc.subject.keyword | BRCA2 | - |
dc.subject.keyword | BRCAPRO | - |
dc.subject.keyword | Myriad BRCA risk calculator | - |
dc.subject.keyword | Risk models | - |
dc.contributor.alternativeName | Kim, Sang Wun | - |
dc.contributor.alternativeName | Kim, Sung Hoon | - |
dc.contributor.alternativeName | Kim, Young Tae | - |
dc.contributor.alternativeName | Nam, Eun Ji | - |
dc.contributor.alternativeName | Park, Hyung Seok | - |
dc.contributor.alternativeName | Eoh, Kyung Jin | - |
dc.contributor.alternativeName | Lee, Seung-Tae | - |
dc.contributor.alternativeName | Lee, Jung-Yun | - |
dc.contributor.alternativeName | Han, Jung Woo | - |
dc.contributor.affiliatedAuthor | Kim, Sung Hoon | - |
dc.contributor.affiliatedAuthor | Kim, Young Tae | - |
dc.contributor.affiliatedAuthor | Nam, Eun Ji | - |
dc.contributor.affiliatedAuthor | Park, Hyung Seok | - |
dc.contributor.affiliatedAuthor | Eoh, Kyung Jin | - |
dc.contributor.affiliatedAuthor | Lee, Seung-Tae | - |
dc.contributor.affiliatedAuthor | Lee, Jung-Yun | - |
dc.contributor.affiliatedAuthor | Han, Jung Woo | - |
dc.contributor.affiliatedAuthor | Kim, Sang Wun | - |
dc.citation.title | Gynecologic Oncology | - |
dc.citation.volume | 145 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 137 | - |
dc.citation.endPage | 141 | - |
dc.identifier.bibliographicCitation | GYNECOLOGIC ONCOLOGY, Vol.145(1) : 137-141, 2017 | - |
dc.date.modified | 2017-11-01 | - |
dc.identifier.rimsid | 43638 | - |
dc.type.rims | ART | - |
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