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Differential Prognostic Implications of Gastric Signet Ring Cell Carcinoma: Stage Adjusted Analysis From a Single High-volume Center in Asia

DC Field Value Language
dc.contributor.author김지현-
dc.contributor.author김현기-
dc.contributor.author노성훈-
dc.contributor.author라선영-
dc.contributor.author안중배-
dc.contributor.author전홍재-
dc.contributor.author정현철-
dc.contributor.author정희철-
dc.contributor.author형우진-
dc.contributor.author박소희-
dc.date.accessioned2017-11-01T08:58:57Z-
dc.date.available2017-11-01T08:58:57Z-
dc.date.issued2017-
dc.identifier.issn0003-4932-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/153871-
dc.description.abstractOBJECTIVE: The aim of this study was to analyze the clinicopathologic characteristics and prognosis of signet ring cell carcinoma (SRC) according to disease status (early vs advanced gastric cancer) in gastric cancer patients. BACKGROUND: The prognostic implication of gastric SRC remains a subject of debate. METHODS: A retrospective analysis was performed using the clinical records of 7667 patients including 1646 SRC patients who underwent radical gastrectomy between 2001 and 2010. A further analysis was also performed after dividing patients into three groups according to histologic subtype: SRC, well-to-moderately differentiated (WMD), and poorly differentiated adenocarcinoma. RESULTS: SRC patients have younger age distribution and female predominance compared with other histologic subtypes. Notably, the distribution of T stage of SRC patients was distinct, located in extremes (T1: 66.2% and T4: 20%). Moreover, the prognosis of SRC in early gastric cancer and advanced gastric cancer was contrasting. In early gastric cancer, SRC demonstrated more favorable prognosis than WMD after adjusting for age, sex, and stage. In contrast, SRC in advanced gastric cancer displayed worse prognosis than WMD. As stage increased, survival outcomes of SRC continued to worsen compared with WMD. CONCLUSIONS: Although conferring favorable prognosis in early stage, SRC has worse prognostic impact as disease progresses. The longstanding controversy of SRC on prognosis may result from disease status at presentation, which leads to differing prognosis compared with tubular adenocarinoma.-
dc.description.statementOfResponsibilityopen-
dc.publisherLippincott Williams & Wilkins-
dc.relation.isPartOfANNALS OF SURGERY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdenocarcinoma/mortality-
dc.subject.MESHAdenocarcinoma/pathology*-
dc.subject.MESHAdenocarcinoma/surgery-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHAsia-
dc.subject.MESHBiopsy, Needle-
dc.subject.MESHCarcinoma, Signet Ring Cell/mortality-
dc.subject.MESHCarcinoma, Signet Ring Cell/pathology*-
dc.subject.MESHCarcinoma, Signet Ring Cell/surgery-
dc.subject.MESHCause of Death*-
dc.subject.MESHCohort Studies-
dc.subject.MESHDisease Progression-
dc.subject.MESHDisease-Free Survival-
dc.subject.MESHFemale-
dc.subject.MESHGastrectomy/methods*-
dc.subject.MESHGastrectomy/mortality-
dc.subject.MESHHospitals, High-Volume-
dc.subject.MESHHumans-
dc.subject.MESHImmunohistochemistry-
dc.subject.MESHKaplan-Meier Estimate-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHMultivariate Analysis-
dc.subject.MESHNeoplasm Invasiveness/pathology-
dc.subject.MESHNeoplasm Recurrence, Local/mortality-
dc.subject.MESHNeoplasm Recurrence, Local/pathology-
dc.subject.MESHNeoplasm Recurrence, Local/surgery*-
dc.subject.MESHNeoplasm Staging Prognosis-
dc.subject.MESHProportional Hazards Models-
dc.subject.MESHRepublic of Korea-
dc.subject.MESHRetrospective Studies-
dc.subject.MESHRisk Assessment-
dc.subject.MESHStomach Neoplasms/mortality-
dc.subject.MESHStomach Neoplasms/pathology*-
dc.subject.MESHStomach Neoplasms/surgery-
dc.subject.MESHSurvival Analysis-
dc.subject.MESHTreatment Outcome-
dc.titleDifferential Prognostic Implications of Gastric Signet Ring Cell Carcinoma: Stage Adjusted Analysis From a Single High-volume Center in Asia-
dc.typeArticle-
dc.publisher.locationUnited States-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Internal Medicine-
dc.contributor.googleauthorHong Jae Chon-
dc.contributor.googleauthorWoo Jin Hyung-
dc.contributor.googleauthorChan Kim-
dc.contributor.googleauthorSohee Park-
dc.contributor.googleauthorJie-Hyun Kim-
dc.contributor.googleauthorChan Hyuk Park-
dc.contributor.googleauthorJoong Bae Ahn-
dc.contributor.googleauthorHyunki Kim-
dc.contributor.googleauthorHyun Cheol Chung-
dc.contributor.googleauthorSun Young Rha-
dc.contributor.googleauthorSung Hoon Noh-
dc.contributor.googleauthorHei-Cheul Jeung-
dc.identifier.doi10.1097/SLA.0000000000001793-
dc.contributor.localIdA01108-
dc.contributor.localIdA01281-
dc.contributor.localIdA01316-
dc.contributor.localIdA02262-
dc.contributor.localIdA03565-
dc.contributor.localIdA03773-
dc.contributor.localIdA03794-
dc.contributor.localIdA04382-
dc.contributor.localIdA01531-
dc.contributor.localIdA00996-
dc.relation.journalcodeJ00178-
dc.identifier.eissn1528-1140 (-
dc.identifier.pmid27232252-
dc.subject.keywordgastric cancer-
dc.subject.keywordprognostic factor-
dc.subject.keywordsignet ring cell carcinoma-
dc.contributor.alternativeNameKim, Ji Hyun-
dc.contributor.alternativeNameKim, Hyun Ki-
dc.contributor.alternativeNameNoh, Sung Hoon-
dc.contributor.alternativeNameRha, Sun Young-
dc.contributor.alternativeNameAhn, Joong Bae-
dc.contributor.alternativeNameChon, Hong Jae-
dc.contributor.alternativeNameChung, Hyun Cheol-
dc.contributor.alternativeNameJeung, Hei Cheul-
dc.contributor.alternativeNameHyung, Woo Jin-
dc.contributor.alternativeNamePark, So Hee-
dc.contributor.affiliatedAuthorKim, Hyun Ki-
dc.contributor.affiliatedAuthorNoh, Sung Hoon-
dc.contributor.affiliatedAuthorRha, Sun Young-
dc.contributor.affiliatedAuthorAhn, Joong Bae-
dc.contributor.affiliatedAuthorChon, Hong Jae-
dc.contributor.affiliatedAuthorChung, Hyun Cheol-
dc.contributor.affiliatedAuthorJeung, Hei Cheul-
dc.contributor.affiliatedAuthorHyung, Woo Jin-
dc.contributor.affiliatedAuthorPark, So Hee-
dc.contributor.affiliatedAuthorKim, Ji Hyun-
dc.citation.titleAnnals of Surgery-
dc.citation.volume265-
dc.citation.number5-
dc.citation.startPage946-
dc.citation.endPage953-
dc.identifier.bibliographicCitationANNALS OF SURGERY, Vol.265(5) : 946-953, 2017-
dc.date.modified2017-11-01-
dc.identifier.rimsid43632-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
4. Graduate School of Public Health (보건대학원) > Graduate School of Public Health (보건대학원) > 1. Journal Papers

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