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Comparison of Clinical Outcomes of BRCA1/2 Pathologic Mutation, Variants of Unknown Significance, or Wild Type Epithelial Ovarian Cancer Patients

DC FieldValueLanguage
dc.contributor.author김상운-
dc.contributor.author김성훈-
dc.contributor.author김영태-
dc.contributor.author남은지-
dc.contributor.author박형석-
dc.contributor.author어경진-
dc.contributor.author이승태-
dc.contributor.author이정윤-
dc.contributor.author한정우-
dc.contributor.author박지수-
dc.date.accessioned2017-11-01T08:58:38Z-
dc.date.available2017-11-01T08:58:38Z-
dc.date.issued2017-
dc.identifier.issn1598-2998-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/153865-
dc.description.abstractPURPOSE: The purpose of this study was to investigate the clinical features of epithelial ovarian cancer (EOC) patients according to BRCA1/2 mutation status (mutation, variant of uncertain significance [VUS], or wild type). MATERIALS AND METHODS: We analyzed 116 patients whose BRCA1/2 genetic test results were available for mutation type and clinical features, including progression-free survival (PFS), overall survival (OS), and response rate. These characteristics were compared according to BRCA1/2 mutation status. RESULTS: Thirty-seven (37/116, 31.9%) BRCA1/2mutations were identified (BRCA1, 30; BRCA2, 7). Mutation of c.3627_3628insA (p.Leu1209_Glu1210?fs) in BRCA1 was observed in five patients (5/37, 13.5%). Twenty-five patients had BRCA1/2 VUSs (25/116, 21.6%). Personal histories of breast cancer were observed in 48.6% of patients with BRCA1/2 mutation (18/37), 16.0% of patients with BRCA1/2 VUS (4/25), and 7.4% of patients with BRCA wild type (4/54) (p < 0.001). Patients with BRCA1/2 mutation showed longer OS than those with BRCA1/2 wild type (p=0.005). No significant differences were detected in PFS, OS, or response rates between patients with BRCA1/2 VUS and BRCA1/2 mutation (p=0.772, p=0.459, and p=0.898, respectively). CONCLUSION: Patientswith BRCA1/2 mutation had longer OS than thosewith BRCA1/2wild type. Patients with BRCA1/2 mutation and BRCA1/2 VUS displayed similar prognoses.-
dc.description.statementOfResponsibilityopen-
dc.formatapplication/pdf-
dc.languageEnglish, Korean-
dc.publisherOfficial journal of Korean Cancer Association-
dc.relation.isPartOfCancer Research and Treatment-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHAlleles-
dc.subject.MESHCombined Modality Therapy-
dc.subject.MESHFemale-
dc.subject.MESHGenes, BRCA1*-
dc.subject.MESHGenes, BRCA2*-
dc.subject.MESHHumans-
dc.subject.MESHMiddle Aged-
dc.subject.MESHMultimodal Imaging/methods-
dc.subject.MESHMutation*-
dc.subject.MESHNeoplasm Grading-
dc.subject.MESHNeoplasm Staging-
dc.subject.MESHNeoplasms, Glandular and Epithelial/diagnosis-
dc.subject.MESHNeoplasms, Glandular and Epithelial/genetics*-
dc.subject.MESHNeoplasms, Glandular and Epithelial/mortality*-
dc.subject.MESHNeoplasms, Glandular and Epithelial/therapy-
dc.subject.MESHOvarian Neoplasms/diagnosis-
dc.subject.MESHOvarian Neoplasms/genetics*-
dc.subject.MESHOvarian Neoplasms/mortality*-
dc.subject.MESHOvarian Neoplasms/therapy-
dc.subject.MESHPrognosis-
dc.subject.MESHSequence Analysis, DNA-
dc.subject.MESHSurvival Analysis-
dc.subject.MESHTreatment Outcome-
dc.titleComparison of Clinical Outcomes of BRCA1/2 Pathologic Mutation, Variants of Unknown Significance, or Wild Type Epithelial Ovarian Cancer Patients-
dc.typeArticle-
dc.publisher.locationKorea-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Obstetrics & Gynecology-
dc.contributor.googleauthorKyung Jin Eoh-
dc.contributor.googleauthorHyung Seok Park-
dc.contributor.googleauthorJi Soo Park-
dc.contributor.googleauthorSeung-Tae Lee-
dc.contributor.googleauthorJeongwoo Han-
dc.contributor.googleauthorJung-Yun Lee-
dc.contributor.googleauthorSang Wun Kim-
dc.contributor.googleauthorSunghoon Kim-
dc.contributor.googleauthorYoung Tae Kim-
dc.contributor.googleauthorEun Ji Nam-
dc.identifier.doi10.4143/crt.2016.135-
dc.contributor.localIdA00595-
dc.contributor.localIdA00729-
dc.contributor.localIdA01262-
dc.contributor.localIdA01753-
dc.contributor.localIdA04842-
dc.contributor.localIdA04627-
dc.contributor.localIdA04638-
dc.contributor.localIdA04325-
dc.contributor.localIdA00526-
dc.relation.journalcodeJ00453-
dc.relation.journalsince2001~-
dc.identifier.pmid27488874-
dc.relation.journalbefore~2001 Journal of the Korean Cancer Research Association (대한암학회지)-
dc.subject.keywordBRCA1-
dc.subject.keywordBRCA2-
dc.subject.keywordOvarian epithelial cancer-
dc.subject.keywordPrognosis-
dc.contributor.alternativeNameKim, Sang Wun-
dc.contributor.alternativeNameKim, Sung Hoon-
dc.contributor.alternativeNameKim, Young Tae-
dc.contributor.alternativeNameNam, Eun Ji-
dc.contributor.alternativeNamePark, Hyung Seok-
dc.contributor.alternativeNameEoh, Kyung Jin-
dc.contributor.alternativeNameLee, Seung-Tae-
dc.contributor.alternativeNameLee, Jung-Yun-
dc.contributor.alternativeNameHan, Jung Woo-
dc.contributor.affiliatedAuthorKim, Sung Hoon-
dc.contributor.affiliatedAuthorKim, Young Tae-
dc.contributor.affiliatedAuthorNam, Eun Ji-
dc.contributor.affiliatedAuthorPark, Hyung Seok-
dc.contributor.affiliatedAuthorEoh, Kyung Jin-
dc.contributor.affiliatedAuthorLee, Seung-Tae-
dc.contributor.affiliatedAuthorLee, Jung-Yun-
dc.contributor.affiliatedAuthorHan, Jung Woo-
dc.contributor.affiliatedAuthorKim, Sang Wun-
dc.citation.titleCancer Research and Treatment-
dc.citation.volume49-
dc.citation.number2-
dc.citation.startPage408-
dc.citation.endPage415-
dc.identifier.bibliographicCitationCancer Research and Treatment, Vol.49(2) : 408-415, 2017-
dc.date.modified2017-11-01-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Obstetrics and Gynecology (산부인과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아청소년과학교실) > 1. Journal Papers

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