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Risk stratification for locally advanced hepatocellular carcinoma using pretreatment alpha-foetoprotein and 18F-fluoro-2-deoxyglucose positron emission tomography

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dc.contributor.author변화경-
dc.contributor.author성진실-
dc.contributor.author윤미진-
dc.contributor.author한광협-
dc.contributor.author황상현-
dc.contributor.author이우중-
dc.date.accessioned2017-11-01T08:58:34Z-
dc.date.available2017-11-01T08:58:34Z-
dc.date.issued2017-
dc.identifier.issn1478-3223-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/153863-
dc.description.abstractBackground & Aims : We investigated the significance of 18F-fluoro-2-deoxyglucose positron emission tomography (18F-FDG PET) parameters and alpha-foetoprotein (AFP) levels in patients with locally advanced hepatocellular carcinoma (LA-HCC). Methods : We retrospectively analysed data of 228 patients with LA-HCC who underwent pretreatment 18F-FDG PET between January 2003 and December 2013. All patients were treated using liver-directed therapy involving radiotherapy. The maximum standardized uptake values (SUVs) and tumour-to-extratumoural liver SUV ratios were calculated, and pretreatment AFP values were obtained. Results : Patients were divided into high and low maximum SUV (SUVmax) groups according to a SUV cut-off of 4.825 determined via receiver-operating characteristic analysis. High AFP level (>550 ng/mL) and high SUVmax were significant predictors of overall and progression-free survival. Better treatment responses and longer median progression-free and overall survival were observed in the low SUVmax group, compared to the high SUVmax group. Similar results were obtained for SUV ratio-based (cut-off value: 2.355) and AFP-based analyses (cut-off value: 550 ng/mL). Three risk groups were identified using the double biomarkers of SUVmax and AFP value as strong prognosticators predictive of survival outcomes. This risk stratification was identified as a prognosticator of survival outcomes, even after subgroup analyses. Furthermore, in high risk group, significantly high extrahepatic failure was shown while in low risk group, significantly low intrahepatic failure. Conclusions : Clinical significance of double biomarkers, SUV and AFP, could be translated into risk stratification for LA-HCC. It could be a valuable tool for survival outcome prediction.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherWiley-Blackwell-
dc.relation.isPartOfLIVER INTERNATIONAL-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleRisk stratification for locally advanced hepatocellular carcinoma using pretreatment alpha-foetoprotein and 18F-fluoro-2-deoxyglucose positron emission tomography-
dc.typeArticle-
dc.publisher.locationUnited States-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Radiation Oncology-
dc.contributor.googleauthorWoo Joong Rhee-
dc.contributor.googleauthorSang Hyun Hwang-
dc.contributor.googleauthorHwa Kyung Byun-
dc.contributor.googleauthorMijin Yun-
dc.contributor.googleauthorKwang-Hyub Han-
dc.contributor.googleauthorJinsil Seong-
dc.identifier.doi10.1111/liv.13297-
dc.contributor.localIdA01956-
dc.contributor.localIdA02550-
dc.contributor.localIdA04268-
dc.contributor.localIdA05136-
dc.relation.journalcodeJ02171-
dc.identifier.eissn1478-3231-
dc.identifier.urlhttp://onlinelibrary.wiley.com/doi/10.1111/liv.13297/abstract-
dc.subject.keywordalpha‐foetoprotein-
dc.subject.keywordFDG‐PET-
dc.subject.keywordhepatocellular carcinoma-
dc.subject.keywordsurvival-
dc.subject.keywordtumour aggressiveness-
dc.contributor.alternativeNameByun, Hwa Kyung-
dc.contributor.alternativeNameSeong, Jin Sil-
dc.contributor.alternativeNameYun, Mi Jin-
dc.contributor.alternativeNameHan, Kwang Hyup-
dc.contributor.affiliatedAuthorSeong, Jin Sil-
dc.contributor.affiliatedAuthorYun, Mi Jin-
dc.contributor.affiliatedAuthorHan, Kwang Hyup-
dc.contributor.affiliatedAuthorByun, Hwa Kyung-
dc.citation.titleLiver International-
dc.citation.volume37-
dc.citation.number4-
dc.citation.startPage592-
dc.citation.endPage599-
dc.identifier.bibliographicCitationLIVER INTERNATIONAL, Vol.37(4) : 592-599, 2017-
dc.date.modified2017-11-01-
dc.identifier.rimsid43624-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Nuclear Medicine (핵의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiation Oncology (방사선종양학교실) > 1. Journal Papers

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