Cited 29 times in
Promoter methylation of PCDH10 by HOTAIR regulates the progression of gastrointestinal stromal tumors
DC Field | Value | Language |
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dc.contributor.author | 김원규 | - |
dc.contributor.author | 김호근 | - |
dc.contributor.author | 윤영훈 | - |
dc.contributor.author | 이상길 | - |
dc.date.accessioned | 2017-11-01T08:31:55Z | - |
dc.date.available | 2017-11-01T08:31:55Z | - |
dc.date.issued | 2016 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/153338 | - |
dc.description.abstract | HOTAIR, a long non-coding RNA (lncRNA), plays a crucial role in tumor initiation and metastasis by interacting with the PRC2 complex and the modulation of its target genes. The role of HOTAIR in gastrointestinal stromal tumors (GISTs) is remains unclear. Herein we investigate the mechanism of HOTAIR in the genesis and promotion of GISTs. The expression of HOTAIR was found to be higher in surgically resected high-risk GISTs than that in low- and intermediate-risk GISTs. Using GIST-T1 and GIST882 cells, we demonstrated that HOTAIR repressed apoptosis, was associated with cell cycle progression, and controlled the invasion and migration of GIST cells. Using a gene expression microarray and lists of HOTAIR-associated candidate genes, we suggested that protocadherin 10 (PCDH10) is a key molecule. PCDH10 expression was significantly decreased in GIST-T1 and GIST882 cells, possibly as a consequence of hypermethylation. We observed that HOTAIR induced PCDH10 methylation in a SUZ12-dependent manner. In this study, we found that the malignant character of GISTs was initiated and amplified by PCDH10 in a process regulated by HOTAIR. In summary, our findings imply that PCDH10 and HOTAIR may be useful markers of disease progression and therapeutic targets. | - |
dc.description.statementOfResponsibility | open | - |
dc.format | application/pdf | - |
dc.language | English | - |
dc.publisher | Impact Journals | - |
dc.relation.isPartOf | ONCOTARGET | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Apoptosis/genetics | - |
dc.subject.MESH | Azacitidine/pharmacology | - |
dc.subject.MESH | Cadherins/genetics* | - |
dc.subject.MESH | Cell Cycle Checkpoints/genetics | - |
dc.subject.MESH | Cell Line, Tumor | - |
dc.subject.MESH | Cell Proliferation | - |
dc.subject.MESH | DNA Methylation* | - |
dc.subject.MESH | Disease Progression | - |
dc.subject.MESH | Epigenesis, Genetic*/drug effects | - |
dc.subject.MESH | Gastrointestinal Stromal Tumors/genetics* | - |
dc.subject.MESH | Gastrointestinal Stromal Tumors/pathology* | - |
dc.subject.MESH | Gene Expression Regulation, Neoplastic* | - |
dc.subject.MESH | Gene Silencing | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Promoter Regions, Genetic* | - |
dc.subject.MESH | RNA, Long Noncoding/genetics* | - |
dc.title | Promoter methylation of PCDH10 by HOTAIR regulates the progression of gastrointestinal stromal tumors | - |
dc.type | Article | - |
dc.publisher.location | United States | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Life Science | - |
dc.contributor.googleauthor | Na Keum Lee | - |
dc.contributor.googleauthor | Jung Hwa Lee | - |
dc.contributor.googleauthor | Won Kyu Kim | - |
dc.contributor.googleauthor | Seongju Yun | - |
dc.contributor.googleauthor | Young Hoon Youn | - |
dc.contributor.googleauthor | Chan Hyuk Park | - |
dc.contributor.googleauthor | Yun Young Choi | - |
dc.contributor.googleauthor | Hogeun Kim | - |
dc.contributor.googleauthor | Sang Kil Lee | - |
dc.identifier.doi | 10.18632/oncotarget.12171 | - |
dc.contributor.localId | A01183 | - |
dc.contributor.localId | A02583 | - |
dc.contributor.localId | A02812 | - |
dc.contributor.localId | A00764 | - |
dc.relation.journalcode | J02421 | - |
dc.identifier.eissn | 1949-2553 | - |
dc.identifier.pmid | 27659532 | - |
dc.subject.keyword | HOTAIR | - |
dc.subject.keyword | PCDH10 | - |
dc.subject.keyword | gastrointestinal stromal tumor | - |
dc.contributor.alternativeName | Kim, Won Kyu | - |
dc.contributor.alternativeName | Kim, Ho Keun | - |
dc.contributor.alternativeName | Youn, Young Hoon | - |
dc.contributor.alternativeName | Lee, Sang Kil | - |
dc.contributor.affiliatedAuthor | Kim, Ho Keun | - |
dc.contributor.affiliatedAuthor | Youn, Young Hoon | - |
dc.contributor.affiliatedAuthor | Lee, Sang Kil | - |
dc.contributor.affiliatedAuthor | Kim, Won Kyu | - |
dc.citation.title | Oncotarget | - |
dc.citation.volume | 7 | - |
dc.citation.number | 46 | - |
dc.citation.startPage | 75307 | - |
dc.citation.endPage | 75318 | - |
dc.identifier.bibliographicCitation | ONCOTARGET, Vol.7(46) : 75307-75318, 2016 | - |
dc.date.modified | 2017-11-01 | - |
dc.identifier.rimsid | 41584 | - |
dc.type.rims | ART | - |
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