횡문근융해증의 이해

Abstract

Rhabdomyolysis is commonly defined as elevation of serum creatine kinase (sCK) level of above 10 times the upper limit of normal followed by a rapid decrease to normal values. Typical clinical features are myalgia, muscular weakness and black colored urine and the most common complication is acute renal failure due to acute tubular necrosis as a result of mechanical obstruction by myoglobin. Most patients experience one episode of rhabdomyolysis by substance abuse, medication, trauma, or seizures. When patients have a history of recurrent rhabdomyolysis, exercise intolerance or family members with neuromuscular disorders, further evaluations for genetic neuromuscular disorder are required. Mortality rate of rhabdomyolysis is, generally, below 10%, but very high in patients with acute renal failure. So, the management in the acute phase should be performed with maintenance of renal function and restore of metabolic derangements by various conservative managements, such as volume replacement.