Cited 6 times in
Development of a New Hybrid Biodegradable Drug-Eluting Stent for the Treatment of Peripheral Artery Disease
DC Field | Value | Language |
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dc.contributor.author | 고영국 | - |
dc.contributor.author | 장양수 | - |
dc.contributor.author | 최동훈 | - |
dc.contributor.author | 홍명기 | - |
dc.date.accessioned | 2017-10-26T08:12:12Z | - |
dc.date.available | 2017-10-26T08:12:12Z | - |
dc.date.issued | 2016 | - |
dc.identifier.issn | 2314-6133 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/153122 | - |
dc.description.abstract | This study aimed to develop a new biodegradable stent for peripheral artery disease (PAD) that could provide sufficient radial force to maintain long-term patency and flexibility. All self-expandable hybrid biodegradable stents were designed by using a knitting structure composed of poly-L-lactic acid (PLLA) and nitinol. Four different types of stents were implanted in 20 iliac arteries in 10 mini pigs as follows: a bare-metal stent (BMS) (group 1, n = 5), a drug-free hybrid stent (group 2, n = 5), a 50% (50?:?100, w/w) paclitaxel (PTX)/poly-lactide-co-glycolic acid (PLGA; fast PTX-releasing form) hybrid stent (group 3, n = 5), and a 30% (30?:?100, w/w) PTX/PLGA (slow PTX-releasing form) hybrid stent (group 4, n = 5). We performed follow-up angiography and intravascular ultrasonography (IVUS) at 4 and 8 weeks. In a comparison of groups 1, 2, 3, and 4, less diameter stenosis was observed in the angiographic analysis for group 4 at the 4-week follow-up (19.0%??±??12.7% versus 39.3%??±??18.1% versus 46.8%??±??38.0% versus 4.8%??±??4.2%, resp.; p = 0.032). IVUS findings further suggested that the neointima of the patients in group 4 tended to be lesser than those of the others. Our new biodegradable 30% PTX/PLGA (slow-releasing form) stent showed more favorable results for patency than the other stent types. | - |
dc.description.statementOfResponsibility | open | - |
dc.format | application/pdf | - |
dc.publisher | Hindawi Pub. Co. | - |
dc.relation.isPartOf | BIOMED RESEARCH INTERNATIONAL | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Absorbable Implants* | - |
dc.subject.MESH | Angiography* | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Drug-Eluting Stents* | - |
dc.subject.MESH | Graft Occlusion, Vascular/diagnostic imaging | - |
dc.subject.MESH | Graft Occlusion, Vascular/physiopathology | - |
dc.subject.MESH | Peripheral Arterial Disease*/diagnostic imaging | - |
dc.subject.MESH | Peripheral Arterial Disease*/physiopathology | - |
dc.subject.MESH | Peripheral Arterial Disease*/surgery | - |
dc.subject.MESH | Polyesters/pharmacology* | - |
dc.subject.MESH | Swine | - |
dc.subject.MESH | Swine, Miniature | - |
dc.subject.MESH | Ultrasonography, Interventional* | - |
dc.title | Development of a New Hybrid Biodegradable Drug-Eluting Stent for the Treatment of Peripheral Artery Disease | - |
dc.type | Article | - |
dc.publisher.location | United States | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Internal Medicine | - |
dc.contributor.googleauthor | Jung-Hee Lee | - |
dc.contributor.googleauthor | Soon-Joong Kim | - |
dc.contributor.googleauthor | Se-Il Park | - |
dc.contributor.googleauthor | Young-Guk Ko | - |
dc.contributor.googleauthor | Donghoon Choi | - |
dc.contributor.googleauthor | Myeong-Ki Hong | - |
dc.contributor.googleauthor | Yangsoo Jang | - |
dc.identifier.doi | 10.1155/2016/6915789 | - |
dc.contributor.localId | A03448 | - |
dc.contributor.localId | A04053 | - |
dc.contributor.localId | A04391 | - |
dc.contributor.localId | A00127 | - |
dc.relation.journalcode | J00315 | - |
dc.identifier.eissn | 2314-6141 | - |
dc.relation.journalsince | 2012~ | - |
dc.identifier.pmid | 27999810 | - |
dc.relation.journalbefore | ~2012 Journal of Biomedicine & Biotechnology | - |
dc.contributor.alternativeName | Ko, Young Guk | - |
dc.contributor.alternativeName | Jang, Yang Soo | - |
dc.contributor.alternativeName | Choi, Dong Hoon | - |
dc.contributor.alternativeName | Hong, Myeong Ki | - |
dc.contributor.affiliatedAuthor | Jang, Yang Soo | - |
dc.contributor.affiliatedAuthor | Choi, Dong Hoon | - |
dc.contributor.affiliatedAuthor | Hong, Myeong Ki | - |
dc.contributor.affiliatedAuthor | Ko, Young Guk | - |
dc.citation.volume | 2016 | - |
dc.citation.startPage | 6915789 | - |
dc.identifier.bibliographicCitation | BIOMED RESEARCH INTERNATIONAL, Vol.2016 : 6915789, 2016 | - |
dc.date.modified | 2017-10-24 | - |
dc.identifier.rimsid | 41124 | - |
dc.type.rims | ART | - |
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