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Development of a New Hybrid Biodegradable Drug-Eluting Stent for the Treatment of Peripheral Artery Disease

DC Field Value Language
dc.contributor.author고영국-
dc.contributor.author장양수-
dc.contributor.author최동훈-
dc.contributor.author홍명기-
dc.date.accessioned2017-10-26T08:12:12Z-
dc.date.available2017-10-26T08:12:12Z-
dc.date.issued2016-
dc.identifier.issn2314-6133-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/153122-
dc.description.abstractThis study aimed to develop a new biodegradable stent for peripheral artery disease (PAD) that could provide sufficient radial force to maintain long-term patency and flexibility. All self-expandable hybrid biodegradable stents were designed by using a knitting structure composed of poly-L-lactic acid (PLLA) and nitinol. Four different types of stents were implanted in 20 iliac arteries in 10 mini pigs as follows: a bare-metal stent (BMS) (group 1, n = 5), a drug-free hybrid stent (group 2, n = 5), a 50% (50?:?100, w/w) paclitaxel (PTX)/poly-lactide-co-glycolic acid (PLGA; fast PTX-releasing form) hybrid stent (group 3, n = 5), and a 30% (30?:?100, w/w) PTX/PLGA (slow PTX-releasing form) hybrid stent (group 4, n = 5). We performed follow-up angiography and intravascular ultrasonography (IVUS) at 4 and 8 weeks. In a comparison of groups 1, 2, 3, and 4, less diameter stenosis was observed in the angiographic analysis for group 4 at the 4-week follow-up (19.0%??±??12.7% versus 39.3%??±??18.1% versus 46.8%??±??38.0% versus 4.8%??±??4.2%, resp.; p = 0.032). IVUS findings further suggested that the neointima of the patients in group 4 tended to be lesser than those of the others. Our new biodegradable 30% PTX/PLGA (slow-releasing form) stent showed more favorable results for patency than the other stent types.-
dc.description.statementOfResponsibilityopen-
dc.formatapplication/pdf-
dc.publisherHindawi Pub. Co.-
dc.relation.isPartOfBIOMED RESEARCH INTERNATIONAL-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAbsorbable Implants*-
dc.subject.MESHAngiography*-
dc.subject.MESHAnimals-
dc.subject.MESHDrug-Eluting Stents*-
dc.subject.MESHGraft Occlusion, Vascular/diagnostic imaging-
dc.subject.MESHGraft Occlusion, Vascular/physiopathology-
dc.subject.MESHPeripheral Arterial Disease*/diagnostic imaging-
dc.subject.MESHPeripheral Arterial Disease*/physiopathology-
dc.subject.MESHPeripheral Arterial Disease*/surgery-
dc.subject.MESHPolyesters/pharmacology*-
dc.subject.MESHSwine-
dc.subject.MESHSwine, Miniature-
dc.subject.MESHUltrasonography, Interventional*-
dc.titleDevelopment of a New Hybrid Biodegradable Drug-Eluting Stent for the Treatment of Peripheral Artery Disease-
dc.typeArticle-
dc.publisher.locationUnited States-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Internal Medicine-
dc.contributor.googleauthorJung-Hee Lee-
dc.contributor.googleauthorSoon-Joong Kim-
dc.contributor.googleauthorSe-Il Park-
dc.contributor.googleauthorYoung-Guk Ko-
dc.contributor.googleauthorDonghoon Choi-
dc.contributor.googleauthorMyeong-Ki Hong-
dc.contributor.googleauthorYangsoo Jang-
dc.identifier.doi10.1155/2016/6915789-
dc.contributor.localIdA03448-
dc.contributor.localIdA04053-
dc.contributor.localIdA04391-
dc.contributor.localIdA00127-
dc.relation.journalcodeJ00315-
dc.identifier.eissn2314-6141-
dc.relation.journalsince2012~-
dc.identifier.pmid27999810-
dc.relation.journalbefore~2012 Journal of Biomedicine & Biotechnology-
dc.contributor.alternativeNameKo, Young Guk-
dc.contributor.alternativeNameJang, Yang Soo-
dc.contributor.alternativeNameChoi, Dong Hoon-
dc.contributor.alternativeNameHong, Myeong Ki-
dc.contributor.affiliatedAuthorJang, Yang Soo-
dc.contributor.affiliatedAuthorChoi, Dong Hoon-
dc.contributor.affiliatedAuthorHong, Myeong Ki-
dc.contributor.affiliatedAuthorKo, Young Guk-
dc.citation.volume2016-
dc.citation.startPage6915789-
dc.identifier.bibliographicCitationBIOMED RESEARCH INTERNATIONAL, Vol.2016 : 6915789, 2016-
dc.date.modified2017-10-24-
dc.identifier.rimsid41124-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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