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Prognostic Validity of the American Joint Committee on Cancer and the European Neuroendocrine Tumors Staging Classifications for Pancreatic Neuroendocrine Tumors: A Retrospective Nationwide Multicenter Study in South Korea
DC Field | Value | Language |
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dc.contributor.author | 송시영 | - |
dc.date.accessioned | 2017-10-26T08:11:40Z | - |
dc.date.available | 2017-10-26T08:11:40Z | - |
dc.date.issued | 2016 | - |
dc.identifier.issn | 0885-3177 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/153104 | - |
dc.description.abstract | OBJECTIVES: Pancreatic neuroendocrine tumors (pNETs) are diverse diseases with different prognosis. The American Joint Committee on Cancer (AJCC) and the European Neuroendocrine Tumor Society (ENETS) introduced 2 different tumor node metastasis (TNM) stages, and the World Health Organization (WHO) proposed WHO 2010 grading system for pNETs. Therefore, we aimed to validate the prognostic relevance of these 3 systems for pNETs in South Korea. METHODS: The Korean Society of Gastrointestinal Cancer created a retrospective registry of pNETs in 153 patients from 15 hospitals between 2002 and 2012. RESULTS: On the basis of the WHO 2010 grade, 2-year progression-free-survival (PFS) rates for G1, G2, and G3 were 92%, 62%, and 25% (P < 0.01). According to ENETS and AJCC staging, 2-year PFS rates for stages I through IV were 94%, 87%, 49%, 20%, and 92%, 61%, 60%, 20%, respectively (P < 0.01). A Cox multivariate regression analysis revealed that the only statistically significant prognostic factor was the TNM classification of either the AJCC or the ENETS stage (P < 0.01). In addition, the κ value between the AJCC and the ENETS stages was 0.46 indicating a ""moderate"" agreement (P < 0.01). CONCLUSIONS: The AJCC and ENETS TNM classifications for pNETs are prognostic for PFS and can be adopted in clinical practice in South Korea. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Lippincott Williams & Wilkins | - |
dc.relation.isPartOf | PANCREAS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adolescent | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Aged, 80 and over | - |
dc.subject.MESH | American Medical Association | - |
dc.subject.MESH | Child | - |
dc.subject.MESH | Disease-Free Survival | - |
dc.subject.MESH | Europe | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Medical Oncology/organization & administration* | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Multivariate Analysis | - |
dc.subject.MESH | Neoplasm Staging | - |
dc.subject.MESH | Neuroendocrine Tumors/classification | - |
dc.subject.MESH | Neuroendocrine Tumors/pathology* | - |
dc.subject.MESH | Pancreas/pathology* | - |
dc.subject.MESH | Pancreatic Neoplasms/classification | - |
dc.subject.MESH | Pancreatic Neoplasms/pathology* | - |
dc.subject.MESH | Prognosis | - |
dc.subject.MESH | Registries/statistics & numerical data | - |
dc.subject.MESH | Republic of Korea | - |
dc.subject.MESH | Retrospective Studies | - |
dc.subject.MESH | United States | - |
dc.subject.MESH | World Health Organization | - |
dc.subject.MESH | Young Adult | - |
dc.title | Prognostic Validity of the American Joint Committee on Cancer and the European Neuroendocrine Tumors Staging Classifications for Pancreatic Neuroendocrine Tumors: A Retrospective Nationwide Multicenter Study in South Korea | - |
dc.type | Article | - |
dc.publisher.location | United States | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Internal Medicine | - |
dc.contributor.googleauthor | Cho, Jae Hee | - |
dc.contributor.googleauthor | Ryu, Ji Kon | - |
dc.contributor.googleauthor | Song, Si Young | - |
dc.contributor.googleauthor | Hwang, Jin-Hyeok | - |
dc.contributor.googleauthor | Lee, Dong Ki | - |
dc.contributor.googleauthor | Woo, Sang Myung | - |
dc.contributor.googleauthor | Joo, Young-Eun | - |
dc.contributor.googleauthor | Jeong, Seok | - |
dc.contributor.googleauthor | Lee, Seung-Ok | - |
dc.contributor.googleauthor | Park, Byung Kyu | - |
dc.contributor.googleauthor | Cheon, Young Koog | - |
dc.contributor.googleauthor | Han, Jimin | - |
dc.contributor.googleauthor | Kim, Tae Nyeun | - |
dc.contributor.googleauthor | Lee, Jun Kyu | - |
dc.contributor.googleauthor | Moon, Sung-Hoon | - |
dc.contributor.googleauthor | Kim, Hyunjin | - |
dc.contributor.googleauthor | Park, Eun Taek | - |
dc.contributor.googleauthor | Hwang, Jae Chul | - |
dc.contributor.googleauthor | Kim, Tae Hyeon | - |
dc.contributor.googleauthor | Jeon, Tae Joo | - |
dc.contributor.googleauthor | Cho, Chang-Min | - |
dc.contributor.googleauthor | Choi, Ho Soon | - |
dc.contributor.googleauthor | Lee, Woo Jin | - |
dc.identifier.doi | 10.1097/MPA.0000000000000586 | - |
dc.contributor.localId | A02035 | - |
dc.relation.journalcode | J02463 | - |
dc.identifier.eissn | 1536-4828 | - |
dc.identifier.pmid | 26765964 | - |
dc.identifier.url | http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&AN=00006676-201608000-00003&LSLINK=80&D=ovft | - |
dc.subject.keyword | pancreatic neuroendocrine tumors | - |
dc.subject.keyword | prognosis | - |
dc.subject.keyword | grading | - |
dc.subject.keyword | staging | - |
dc.contributor.alternativeName | Song, Si Young | - |
dc.contributor.affiliatedAuthor | Song, Si Young | - |
dc.citation.volume | 45 | - |
dc.citation.number | 7 | - |
dc.citation.startPage | 941 | - |
dc.citation.endPage | 946 | - |
dc.identifier.bibliographicCitation | PANCREAS, Vol.45(7) : 941-946, 2016 | - |
dc.date.modified | 2017-10-24 | - |
dc.identifier.rimsid | 41106 | - |
dc.type.rims | ART | - |
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