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Prognostic Validity of the American Joint Committee on Cancer and the European Neuroendocrine Tumors Staging Classifications for Pancreatic Neuroendocrine Tumors: A Retrospective Nationwide Multicenter Study in South Korea

DC FieldValueLanguage
dc.contributor.author송시영-
dc.date.accessioned2017-10-26T08:11:40Z-
dc.date.available2017-10-26T08:11:40Z-
dc.date.issued2016-
dc.identifier.issn0885-3177-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/153104-
dc.description.abstractOBJECTIVES: Pancreatic neuroendocrine tumors (pNETs) are diverse diseases with different prognosis. The American Joint Committee on Cancer (AJCC) and the European Neuroendocrine Tumor Society (ENETS) introduced 2 different tumor node metastasis (TNM) stages, and the World Health Organization (WHO) proposed WHO 2010 grading system for pNETs. Therefore, we aimed to validate the prognostic relevance of these 3 systems for pNETs in South Korea. METHODS: The Korean Society of Gastrointestinal Cancer created a retrospective registry of pNETs in 153 patients from 15 hospitals between 2002 and 2012. RESULTS: On the basis of the WHO 2010 grade, 2-year progression-free-survival (PFS) rates for G1, G2, and G3 were 92%, 62%, and 25% (P < 0.01). According to ENETS and AJCC staging, 2-year PFS rates for stages I through IV were 94%, 87%, 49%, 20%, and 92%, 61%, 60%, 20%, respectively (P < 0.01). A Cox multivariate regression analysis revealed that the only statistically significant prognostic factor was the TNM classification of either the AJCC or the ENETS stage (P < 0.01). In addition, the κ value between the AJCC and the ENETS stages was 0.46 indicating a ""moderate"" agreement (P < 0.01). CONCLUSIONS: The AJCC and ENETS TNM classifications for pNETs are prognostic for PFS and can be adopted in clinical practice in South Korea.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherLippincott Williams & Wilkins-
dc.relation.isPartOfPANCREAS-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdolescent-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHAged, 80 and over-
dc.subject.MESHAmerican Medical Association-
dc.subject.MESHChild-
dc.subject.MESHDisease-Free Survival-
dc.subject.MESHEurope-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHMale-
dc.subject.MESHMedical Oncology/organization & administration*-
dc.subject.MESHMiddle Aged-
dc.subject.MESHMultivariate Analysis-
dc.subject.MESHNeoplasm Staging-
dc.subject.MESHNeuroendocrine Tumors/classification-
dc.subject.MESHNeuroendocrine Tumors/pathology*-
dc.subject.MESHPancreas/pathology*-
dc.subject.MESHPancreatic Neoplasms/classification-
dc.subject.MESHPancreatic Neoplasms/pathology*-
dc.subject.MESHPrognosis-
dc.subject.MESHRegistries/statistics & numerical data-
dc.subject.MESHRepublic of Korea-
dc.subject.MESHRetrospective Studies-
dc.subject.MESHUnited States-
dc.subject.MESHWorld Health Organization-
dc.subject.MESHYoung Adult-
dc.titlePrognostic Validity of the American Joint Committee on Cancer and the European Neuroendocrine Tumors Staging Classifications for Pancreatic Neuroendocrine Tumors: A Retrospective Nationwide Multicenter Study in South Korea-
dc.typeArticle-
dc.publisher.locationUnited States-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Internal Medicine-
dc.contributor.googleauthorCho, Jae Hee-
dc.contributor.googleauthorRyu, Ji Kon-
dc.contributor.googleauthorSong, Si Young-
dc.contributor.googleauthorHwang, Jin-Hyeok-
dc.contributor.googleauthorLee, Dong Ki-
dc.contributor.googleauthorWoo, Sang Myung-
dc.contributor.googleauthorJoo, Young-Eun-
dc.contributor.googleauthorJeong, Seok-
dc.contributor.googleauthorLee, Seung-Ok-
dc.contributor.googleauthorPark, Byung Kyu-
dc.contributor.googleauthorCheon, Young Koog-
dc.contributor.googleauthorHan, Jimin-
dc.contributor.googleauthorKim, Tae Nyeun-
dc.contributor.googleauthorLee, Jun Kyu-
dc.contributor.googleauthorMoon, Sung-Hoon-
dc.contributor.googleauthorKim, Hyunjin-
dc.contributor.googleauthorPark, Eun Taek-
dc.contributor.googleauthorHwang, Jae Chul-
dc.contributor.googleauthorKim, Tae Hyeon-
dc.contributor.googleauthorJeon, Tae Joo-
dc.contributor.googleauthorCho, Chang-Min-
dc.contributor.googleauthorChoi, Ho Soon-
dc.contributor.googleauthorLee, Woo Jin-
dc.identifier.doi10.1097/MPA.0000000000000586-
dc.contributor.localIdA02035-
dc.relation.journalcodeJ02463-
dc.identifier.eissn1536-4828-
dc.identifier.pmid26765964-
dc.identifier.urlhttp://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&AN=00006676-201608000-00003&LSLINK=80&D=ovft-
dc.subject.keywordpancreatic neuroendocrine tumors-
dc.subject.keywordprognosis-
dc.subject.keywordgrading-
dc.subject.keywordstaging-
dc.contributor.alternativeNameSong, Si Young-
dc.contributor.affiliatedAuthorSong, Si Young-
dc.citation.volume45-
dc.citation.number7-
dc.citation.startPage941-
dc.citation.endPage946-
dc.identifier.bibliographicCitationPANCREAS, Vol.45(7) : 941-946, 2016-
dc.date.modified2017-10-24-
dc.identifier.rimsid41106-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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