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Prognostic Validity of the American Joint Committee on Cancer and the European Neuroendocrine Tumors Staging Classifications for Pancreatic Neuroendocrine Tumors: A Retrospective Nationwide Multicenter Study in South Korea

 Cho, Jae Hee  ;  Ryu, Ji Kon  ;  Song, Si Young  ;  Hwang, Jin-Hyeok  ;  Lee, Dong Ki  ;  Woo, Sang Myung  ;  Joo, Young-Eun  ;  Jeong, Seok  ;  Lee, Seung-Ok  ;  Park, Byung Kyu  ;  Cheon, Young Koog  ;  Han, Jimin  ;  Kim, Tae Nyeun  ;  Lee, Jun Kyu  ;  Moon, Sung-Hoon  ;  Kim, Hyunjin  ;  Park, Eun Taek  ;  Hwang, Jae Chul  ;  Kim, Tae Hyeon  ;  Jeon, Tae Joo  ;  Cho, Chang-Min  ;  Choi, Ho Soon  ;  Lee, Woo Jin 
 PANCREAS, Vol.45(7) : 941-946, 2016 
Journal Title
Issue Date
Adolescent ; Adult ; Aged ; Aged, 80 and over ; American Medical Association ; Child ; Disease-Free Survival ; Europe ; Female ; Humans ; Male ; Medical Oncology/organization & administration* ; Middle Aged ; Multivariate Analysis ; Neoplasm Staging ; Neuroendocrine Tumors/classification ; Neuroendocrine Tumors/pathology* ; Pancreas/pathology* ; Pancreatic Neoplasms/classification ; Pancreatic Neoplasms/pathology* ; Prognosis ; Registries/statistics & numerical data ; Republic of Korea ; Retrospective Studies ; United States ; World Health Organization ; Young Adult
pancreatic neuroendocrine tumors ; prognosis ; grading ; staging
OBJECTIVES: Pancreatic neuroendocrine tumors (pNETs) are diverse diseases with different prognosis. The American Joint Committee on Cancer (AJCC) and the European Neuroendocrine Tumor Society (ENETS) introduced 2 different tumor node metastasis (TNM) stages, and the World Health Organization (WHO) proposed WHO 2010 grading system for pNETs. Therefore, we aimed to validate the prognostic relevance of these 3 systems for pNETs in South Korea. METHODS: The Korean Society of Gastrointestinal Cancer created a retrospective registry of pNETs in 153 patients from 15 hospitals between 2002 and 2012. RESULTS: On the basis of the WHO 2010 grade, 2-year progression-free-survival (PFS) rates for G1, G2, and G3 were 92%, 62%, and 25% (P < 0.01). According to ENETS and AJCC staging, 2-year PFS rates for stages I through IV were 94%, 87%, 49%, 20%, and 92%, 61%, 60%, 20%, respectively (P < 0.01). A Cox multivariate regression analysis revealed that the only statistically significant prognostic factor was the TNM classification of either the AJCC or the ENETS stage (P < 0.01). In addition, the κ value between the AJCC and the ENETS stages was 0.46 indicating a ""moderate"" agreement (P < 0.01). CONCLUSIONS: The AJCC and ENETS TNM classifications for pNETs are prognostic for PFS and can be adopted in clinical practice in South Korea.
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1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Song, Si Young(송시영) ORCID logo https://orcid.org/0000-0002-1417-4314
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