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Can lymphovascular invasion replace the prognostic value of lymph node involvement in patients with upper tract urothelial carcinoma after radical nephroureterectomy?

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dc.contributor.author최영득-
dc.date.accessioned2017-10-26T08:10:16Z-
dc.date.available2017-10-26T08:10:16Z-
dc.date.issued2016-
dc.identifier.issn1911-6470-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/153061-
dc.description.abstractINTRODUCTION: This study aimed to evaluate whether lymphovascular invasion (LVI) can replace lymph node (LN) involvement as a prognostic marker in patients who do not undergo lymph node dissection (LND) during surgery in patients with upper tract urothelial carcinoma (UTUC). METHODS: A total of 505 patients who underwent radical nephroureterectomy (RNU) were recruited from four academic centres and divided into four groups: node negative (N0, Group 1); node positive (N+, Group 2); no LND without LVI (NxLVI-, Group 3); and no LND with LVI (NxLVI+, Group 4). RESULTS: Patients in Group 2 had larger tumours, a higher incidence of left-sided involvement, more aggressive T stage and grade, and a higher positive surgical margin rate than patients in other groups. Pathological features (T stage and grade) were poorer in Group 4 than in Groups 1 and 3. Compared to other groups, Group 2 had the worst prognostic outcomes regarding locoregional/distant metastasis-free survival (MFS), cancer-specific survival (CSS), and overall survival (OS). LVI and LN status in Group 4 was not associated with MFS in multivariate analysis. Among Nx diseases, LVI was not an independent predictor of MFS or CCS. The small number of cases in Groups 2 and 4 is a major limitation of this study. CONCLUSIONS: Clinical outcomes according to LVI did not correlate with those outcomes predicted by LN involvement in patients with UTUC. Therefore, LVI may not be used as a substitute for nodal status in patients who do not undergo LND at the time of surgery.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish, French-
dc.publisherCanadian Medical Association-
dc.relation.isPartOfCUAJ-CANADIAN UROLOGICAL ASSOCIATION JOURNAL-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleCan lymphovascular invasion replace the prognostic value of lymph node involvement in patients with upper tract urothelial carcinoma after radical nephroureterectomy?-
dc.typeArticle-
dc.publisher.locationCanada-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Urology-
dc.contributor.googleauthorEun Sang Yoo-
dc.contributor.googleauthorYun-Sok Ha-
dc.contributor.googleauthorJun Nyung Lee-
dc.contributor.googleauthorBum Soo Kim-
dc.contributor.googleauthorBup Wan Kim-
dc.contributor.googleauthorSeok-Soo Byun-
dc.contributor.googleauthorYoung Deuk Choi-
dc.contributor.googleauthorHo Won Kang-
dc.contributor.googleauthorSeok-Joong Yun-
dc.contributor.googleauthorWun-Jae Kim-
dc.contributor.googleauthorJeong Hyun Kim-
dc.contributor.googleauthorTae Gyun Kwon-
dc.identifier.doi10.5489/cuaj.3557-
dc.contributor.localIdA04111-
dc.relation.journalcodeJ02986-
dc.identifier.eissn1920-1214-
dc.relation.journalsince2007-
dc.identifier.pmid28255413-
dc.contributor.alternativeNameChoi, Young Deuk-
dc.contributor.affiliatedAuthorChoi, Young Deuk-
dc.citation.volume10-
dc.citation.number7~8-
dc.citation.startPage229-
dc.citation.endPage236-
dc.identifier.bibliographicCitationCUAJ-CANADIAN UROLOGICAL ASSOCIATION JOURNAL, Vol.10(7~8) : 229-236, 2016-
dc.date.modified2017-10-24-
dc.identifier.rimsid41065-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Urology (비뇨의학교실) > 1. Journal Papers

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