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Can lymphovascular invasion replace the prognostic value of lymph node involvement in patients with upper tract urothelial carcinoma after radical nephroureterectomy?
DC Field | Value | Language |
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dc.contributor.author | 최영득 | - |
dc.date.accessioned | 2017-10-26T08:10:16Z | - |
dc.date.available | 2017-10-26T08:10:16Z | - |
dc.date.issued | 2016 | - |
dc.identifier.issn | 1911-6470 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/153061 | - |
dc.description.abstract | INTRODUCTION: This study aimed to evaluate whether lymphovascular invasion (LVI) can replace lymph node (LN) involvement as a prognostic marker in patients who do not undergo lymph node dissection (LND) during surgery in patients with upper tract urothelial carcinoma (UTUC). METHODS: A total of 505 patients who underwent radical nephroureterectomy (RNU) were recruited from four academic centres and divided into four groups: node negative (N0, Group 1); node positive (N+, Group 2); no LND without LVI (NxLVI-, Group 3); and no LND with LVI (NxLVI+, Group 4). RESULTS: Patients in Group 2 had larger tumours, a higher incidence of left-sided involvement, more aggressive T stage and grade, and a higher positive surgical margin rate than patients in other groups. Pathological features (T stage and grade) were poorer in Group 4 than in Groups 1 and 3. Compared to other groups, Group 2 had the worst prognostic outcomes regarding locoregional/distant metastasis-free survival (MFS), cancer-specific survival (CSS), and overall survival (OS). LVI and LN status in Group 4 was not associated with MFS in multivariate analysis. Among Nx diseases, LVI was not an independent predictor of MFS or CCS. The small number of cases in Groups 2 and 4 is a major limitation of this study. CONCLUSIONS: Clinical outcomes according to LVI did not correlate with those outcomes predicted by LN involvement in patients with UTUC. Therefore, LVI may not be used as a substitute for nodal status in patients who do not undergo LND at the time of surgery. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English, French | - |
dc.publisher | Canadian Medical Association | - |
dc.relation.isPartOf | CUAJ-CANADIAN UROLOGICAL ASSOCIATION JOURNAL | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Can lymphovascular invasion replace the prognostic value of lymph node involvement in patients with upper tract urothelial carcinoma after radical nephroureterectomy? | - |
dc.type | Article | - |
dc.publisher.location | Canada | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Urology | - |
dc.contributor.googleauthor | Eun Sang Yoo | - |
dc.contributor.googleauthor | Yun-Sok Ha | - |
dc.contributor.googleauthor | Jun Nyung Lee | - |
dc.contributor.googleauthor | Bum Soo Kim | - |
dc.contributor.googleauthor | Bup Wan Kim | - |
dc.contributor.googleauthor | Seok-Soo Byun | - |
dc.contributor.googleauthor | Young Deuk Choi | - |
dc.contributor.googleauthor | Ho Won Kang | - |
dc.contributor.googleauthor | Seok-Joong Yun | - |
dc.contributor.googleauthor | Wun-Jae Kim | - |
dc.contributor.googleauthor | Jeong Hyun Kim | - |
dc.contributor.googleauthor | Tae Gyun Kwon | - |
dc.identifier.doi | 10.5489/cuaj.3557 | - |
dc.contributor.localId | A04111 | - |
dc.relation.journalcode | J02986 | - |
dc.identifier.eissn | 1920-1214 | - |
dc.relation.journalsince | 2007 | - |
dc.identifier.pmid | 28255413 | - |
dc.contributor.alternativeName | Choi, Young Deuk | - |
dc.contributor.affiliatedAuthor | Choi, Young Deuk | - |
dc.citation.volume | 10 | - |
dc.citation.number | 7~8 | - |
dc.citation.startPage | 229 | - |
dc.citation.endPage | 236 | - |
dc.identifier.bibliographicCitation | CUAJ-CANADIAN UROLOGICAL ASSOCIATION JOURNAL, Vol.10(7~8) : 229-236, 2016 | - |
dc.date.modified | 2017-10-24 | - |
dc.identifier.rimsid | 41065 | - |
dc.type.rims | ART | - |
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