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Renal Dysfunction during Tenofovir Use in a Regional Cohort of HIV-Infected Individuals in the Asia-Pacific

DC Field Value Language
dc.contributor.author최준용-
dc.date.accessioned2017-10-26T08:10:15Z-
dc.date.available2017-10-26T08:10:15Z-
dc.date.issued2016-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/153060-
dc.description.abstractBACKGROUND: In resource-limited settings, routine monitoring of renal function during antiretroviral therapy (ART) has not been recommended. However, concerns for tenofovir disoproxil fumarate (TDF)-related nephrotoxicity persist with increased use. METHODS: We investigated serum creatinine (S-Cr) monitoring rates before and during ART and the incidence and prevalence of renal dysfunction after starting TDF by using data from a regional cohort of HIV-infected individuals in the Asia-Pacific. Time to renal dysfunction was defined as time from TDF initiation to the decline in estimated glomerular filtration rate (eGFR) to <60 ml/min/1.73m2 with >30% reduction from baseline using the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation or the decision to stop TDF for reported TDF-nephrotoxicity. Predictors of S-Cr monitoring rates were assessed by Poisson regression and risk factors for developing renal dysfunction were assessed by Cox regression. RESULTS: Among 2,425 patients who received TDF, S-Cr monitoring rates increased from 1.01 to 1.84 per person per year after starting TDF (incidence rate ratio 1.68, 95%CI 1.62-1.74, p <0.001). Renal dysfunction on TDF occurred in 103 patients over 5,368 person-years of TDF use (4.2%; incidence 1.75 per 100 person-years). Risk factors for developing renal dysfunction included older age (>50 vs. ≤30, hazard ratio [HR] 5.39, 95%CI 2.52-11.50, p <0.001; and using PI-based regimen (HR 1.93, 95%CI 1.22-3.07, p = 0.005). Having an eGFR prior to TDF (pre-TDF eGFR) of ≥60 ml/min/1.73m2 showed a protective effect (HR 0.38, 95%CI, 0.17-0.85, p = 0.018). CONCLUSIONS: Renal dysfunction on commencing TDF use was not common, however, older age, lower baseline eGFR and PI-based ART were associated with higher risk of renal dysfunction during TDF use in adult HIV-infected individuals in the Asia-Pacific region.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherPublic Library of Science-
dc.relation.isPartOfPLOS ONE-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdult-
dc.subject.MESHAnti-HIV Agents/adverse effects*-
dc.subject.MESHAnti-HIV Agents/therapeutic use-
dc.subject.MESHCreatinine/blood-
dc.subject.MESHDatabases, Factual-
dc.subject.MESHFemale-
dc.subject.MESHGlomerular Filtration Rate-
dc.subject.MESHHIV Infections/drug therapy*-
dc.subject.MESHHumans-
dc.subject.MESHKidney/drug effects*-
dc.subject.MESHKidney/physiopathology*-
dc.subject.MESHKidney Diseases/chemically induced*-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHPoisson Distribution-
dc.subject.MESHProportional Hazards Models-
dc.subject.MESHProspective Studies-
dc.subject.MESHRisk Factors-
dc.subject.MESHTenofovir/adverse effects*-
dc.subject.MESHTenofovir/therapeutic use-
dc.titleRenal Dysfunction during Tenofovir Use in a Regional Cohort of HIV-Infected Individuals in the Asia-Pacific-
dc.typeArticle-
dc.publisher.locationUnited States-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Internal Medicine-
dc.contributor.googleauthorJunko Tanuma-
dc.contributor.googleauthorAwachana Jiamsakul-
dc.contributor.googleauthorAbhimanyuMakane-
dc.contributor.googleauthorAnchalee Avihingsanon-
dc.contributor.googleauthorOon Tek Ng-
dc.contributor.googleauthorSasisopin Kiertiburanakul-
dc.contributor.googleauthorRomanee Chaiwarith-
dc.contributor.googleauthorNagalingeswaran Kumarasamy-
dc.contributor.googleauthorKinhVanNguyen-
dc.contributor.googleauthorThuy Thanh Pham-
dc.contributor.googleauthorManPo Lee-
dc.contributor.googleauthorRossana Ditangco-
dc.contributor.googleauthorTuti Parwati Merati-
dc.contributor.googleauthorJun Yong Choi-
dc.contributor.googleauthorWingWai Wong-
dc.contributor.googleauthorAdeeba Kamarulzaman-
dc.contributor.googleauthorEvy Yunihastuti1-
dc.contributor.googleauthorBenedict LH Sim-
dc.contributor.googleauthorWinai Ratanasuwan-
dc.contributor.googleauthorPacharee Kantipong-
dc.contributor.googleauthorFujie Zhang-
dc.contributor.googleauthorMahiran Mustafa-
dc.contributor.googleauthorVonthanak Saphonn-
dc.contributor.googleauthorSanjay Pujari-
dc.contributor.googleauthorAnnette H. Sohn-
dc.identifier.doi10.1371/journal.pone.0161562-
dc.contributor.localIdA04191-
dc.relation.journalcodeJ02540-
dc.identifier.eissn1932-6203-
dc.identifier.pmid27560968-
dc.contributor.alternativeNameChoi, Jun Yong-
dc.contributor.affiliatedAuthorChoi, Jun Yong-
dc.citation.volume11-
dc.citation.number8-
dc.citation.startPagee0161562-
dc.identifier.bibliographicCitationPLOS ONE, Vol.11(8) : e0161562, 2016-
dc.date.modified2017-10-24-
dc.identifier.rimsid41064-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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