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The diagnostic ability of 18F-FDG PET/CT for mediastinal lymph node staging using 18F-FDG uptake and volumetric CT histogram analysis in non-small cell lung cancer

DC FieldValueLanguage
dc.contributor.author강원준-
dc.contributor.author김은영-
dc.contributor.author윤미진-
dc.contributor.author이재훈-
dc.contributor.author김대준-
dc.date.accessioned2017-10-26T08:09:17Z-
dc.date.available2017-10-26T08:09:17Z-
dc.date.issued2016-
dc.identifier.issn0938-7994-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/153037-
dc.description.abstractOBJECTIVES: To evaluate the clinical implications of lymph node (LN) density on 18F-FDG PET/CT for mediastinal LN characterization in non-small cell lung cancer (NSCLC). METHODS: One hundred and fifty-two patients with 271 mediastinal LNs who underwent PET/CT and endobronchial ultrasound-guided transbronchial needle aspiration for staging were enrolled. Maximum standardized uptake value (SUVmax), short axis diameter, LN-to-primary cancer ratio of SUVmax, and median Hounsfield unit (HU) based on CT histogram were correlated to histopathology. RESULTS: Of 271 nodes, 162 (59.8 %) were malignant. SUVmax, short axis diameter, and LPR of malignant LNs were higher than those of benign nodes. Among malignant LNs, 71.0 % had median HU between 25 and 45, while 78.9 % of benign LNs had values <25 HU or >45 HU. Using a cutoff value of 4.0, SUVmax showed the highest diagnostic ability for detecting malignant LNs with a specificity of 94.5 %, but showing a sensitivity of 70.4 %. Using additional density criteria (median HU 25-45) in LNs with 2.0< SUVmax ≤4.0, the sensitivity increased to 88.3 % with the specificity of 82.6 %. CONCLUSIONS: LN density is useful for the characterization of LNs with mild 18F-FDG uptake. The risk of mediastinal LN metastasis in NSCLC patients could be further stratified using both 18F-FDG uptake and LN density. KEY POINTS: ? SUVmax showed the highest diagnostic ability for detecting malignant LNs. ? LN density was useful in characterization of LNs with mild FDG uptake. ? SUVmax and LN density together could stratify the risk of LN metastasis.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherSpringer International-
dc.relation.isPartOfEUROPEAN RADIOLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleThe diagnostic ability of 18F-FDG PET/CT for mediastinal lymph node staging using 18F-FDG uptake and volumetric CT histogram analysis in non-small cell lung cancer-
dc.typeArticle-
dc.publisher.locationGermany-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Nuclear Medicine-
dc.contributor.googleauthorJeong Won Lee-
dc.contributor.googleauthorEun Young Kim-
dc.contributor.googleauthorDae Joon Kim-
dc.contributor.googleauthorJae-Hoon Lee-
dc.contributor.googleauthorWon Jun Kang-
dc.contributor.googleauthorJong Doo Lee-
dc.contributor.googleauthorMijin Yun-
dc.identifier.doi10.1007/s00330-016-4292-8-
dc.contributor.localIdA00811-
dc.contributor.localIdA02550-
dc.contributor.localIdA03093-
dc.contributor.localIdA03138-
dc.contributor.localIdA00368-
dc.contributor.localIdA00062-
dc.relation.journalcodeJ00851-
dc.identifier.eissn1432-1084-
dc.identifier.pmid26943133-
dc.identifier.urlhttps://link.springer.com/article/10.1007%2Fs00330-016-4292-8-
dc.contributor.alternativeNameKang, Won Jun-
dc.contributor.alternativeNameKim, Eun Young-
dc.contributor.alternativeNameYun, Mi Jin-
dc.contributor.alternativeNameLee, Jae Hoon-
dc.contributor.alternativeNameKim, Dae Joon-
dc.contributor.affiliatedAuthorKim, Eun Young-
dc.contributor.affiliatedAuthorYun, Mi Jin-
dc.contributor.affiliatedAuthorLee, Jae Hoon-
dc.contributor.affiliatedAuthorKim, Dae Joon-
dc.contributor.affiliatedAuthorKang, Won Jun-
dc.citation.volume26-
dc.citation.number12-
dc.citation.startPage4515-
dc.citation.endPage4523-
dc.identifier.bibliographicCitationEUROPEAN RADIOLOGY, Vol.26(12) : 4515-4523, 2016-
dc.date.modified2017-10-24-
dc.identifier.rimsid41042-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Nuclear Medicine (핵의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Thoracic and Cardiovascular Surgery (흉부외과학교실) > 1. Journal Papers

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