Cited 24 times in
The diagnostic ability of 18F-FDG PET/CT for mediastinal lymph node staging using 18F-FDG uptake and volumetric CT histogram analysis in non-small cell lung cancer
DC Field | Value | Language |
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dc.contributor.author | 강원준 | - |
dc.contributor.author | 김은영 | - |
dc.contributor.author | 윤미진 | - |
dc.contributor.author | 이재훈 | - |
dc.contributor.author | 김대준 | - |
dc.date.accessioned | 2017-10-26T08:09:17Z | - |
dc.date.available | 2017-10-26T08:09:17Z | - |
dc.date.issued | 2016 | - |
dc.identifier.issn | 0938-7994 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/153037 | - |
dc.description.abstract | OBJECTIVES: To evaluate the clinical implications of lymph node (LN) density on 18F-FDG PET/CT for mediastinal LN characterization in non-small cell lung cancer (NSCLC). METHODS: One hundred and fifty-two patients with 271 mediastinal LNs who underwent PET/CT and endobronchial ultrasound-guided transbronchial needle aspiration for staging were enrolled. Maximum standardized uptake value (SUVmax), short axis diameter, LN-to-primary cancer ratio of SUVmax, and median Hounsfield unit (HU) based on CT histogram were correlated to histopathology. RESULTS: Of 271 nodes, 162 (59.8 %) were malignant. SUVmax, short axis diameter, and LPR of malignant LNs were higher than those of benign nodes. Among malignant LNs, 71.0 % had median HU between 25 and 45, while 78.9 % of benign LNs had values <25 HU or >45 HU. Using a cutoff value of 4.0, SUVmax showed the highest diagnostic ability for detecting malignant LNs with a specificity of 94.5 %, but showing a sensitivity of 70.4 %. Using additional density criteria (median HU 25-45) in LNs with 2.0< SUVmax ≤4.0, the sensitivity increased to 88.3 % with the specificity of 82.6 %. CONCLUSIONS: LN density is useful for the characterization of LNs with mild 18F-FDG uptake. The risk of mediastinal LN metastasis in NSCLC patients could be further stratified using both 18F-FDG uptake and LN density. KEY POINTS: ? SUVmax showed the highest diagnostic ability for detecting malignant LNs. ? LN density was useful in characterization of LNs with mild FDG uptake. ? SUVmax and LN density together could stratify the risk of LN metastasis. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Springer International | - |
dc.relation.isPartOf | EUROPEAN RADIOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | The diagnostic ability of 18F-FDG PET/CT for mediastinal lymph node staging using 18F-FDG uptake and volumetric CT histogram analysis in non-small cell lung cancer | - |
dc.type | Article | - |
dc.publisher.location | Germany | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Nuclear Medicine | - |
dc.contributor.googleauthor | Jeong Won Lee | - |
dc.contributor.googleauthor | Eun Young Kim | - |
dc.contributor.googleauthor | Dae Joon Kim | - |
dc.contributor.googleauthor | Jae-Hoon Lee | - |
dc.contributor.googleauthor | Won Jun Kang | - |
dc.contributor.googleauthor | Jong Doo Lee | - |
dc.contributor.googleauthor | Mijin Yun | - |
dc.identifier.doi | 10.1007/s00330-016-4292-8 | - |
dc.contributor.localId | A00811 | - |
dc.contributor.localId | A02550 | - |
dc.contributor.localId | A03093 | - |
dc.contributor.localId | A03138 | - |
dc.contributor.localId | A00368 | - |
dc.contributor.localId | A00062 | - |
dc.relation.journalcode | J00851 | - |
dc.identifier.eissn | 1432-1084 | - |
dc.identifier.pmid | 26943133 | - |
dc.identifier.url | https://link.springer.com/article/10.1007%2Fs00330-016-4292-8 | - |
dc.contributor.alternativeName | Kang, Won Jun | - |
dc.contributor.alternativeName | Kim, Eun Young | - |
dc.contributor.alternativeName | Yun, Mi Jin | - |
dc.contributor.alternativeName | Lee, Jae Hoon | - |
dc.contributor.alternativeName | Kim, Dae Joon | - |
dc.contributor.affiliatedAuthor | Kim, Eun Young | - |
dc.contributor.affiliatedAuthor | Yun, Mi Jin | - |
dc.contributor.affiliatedAuthor | Lee, Jae Hoon | - |
dc.contributor.affiliatedAuthor | Kim, Dae Joon | - |
dc.contributor.affiliatedAuthor | Kang, Won Jun | - |
dc.citation.volume | 26 | - |
dc.citation.number | 12 | - |
dc.citation.startPage | 4515 | - |
dc.citation.endPage | 4523 | - |
dc.identifier.bibliographicCitation | EUROPEAN RADIOLOGY, Vol.26(12) : 4515-4523, 2016 | - |
dc.date.modified | 2017-10-24 | - |
dc.identifier.rimsid | 41042 | - |
dc.type.rims | ART | - |
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