Cited 12 times in
Detection of MYD88 L265P in patients with lymphoplasmacytic lymphoma/Waldenstrom macroglobulinemia and other B-cell non-Hodgkin lymphomas
DC Field | Value | Language |
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dc.contributor.author | 이승태 | - |
dc.date.accessioned | 2017-10-26T08:09:04Z | - |
dc.date.available | 2017-10-26T08:09:04Z | - |
dc.date.issued | 2016 | - |
dc.identifier.issn | 2287-979X | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/153032 | - |
dc.description.abstract | BACKGROUND: Recent studies have identified a high prevalence of the MYD88 L265P mutation in lymphoplasmacytic lymphoma (LPL)/Waldenstrom macroglobulinemia (WM) cases, whereas low frequencies have been observed in other B cell non-Hodgkin lymphomas (NHLs). METHODS: We evaluated the sensitivity of the mutant enrichment 3'-modified oligonucleotide (MEMO)-PCR technique, a new detection method. We examined the MYD88 L265P mutation in a series of Korean patients with LPL/WM and other B cell NHLs in bone marrow aspirates, using the MEMO-PCR technique. RESULTS: The sensitivity of MEMO-PCR was estimated to be approximately 10-16.7%. MYD88 L265P was detected in 21 of 28 LPL cases (75%) and only three of 69 B cell NHL cases (4.3%). CONCLUSION: Although MEMO-PCR had relatively low sensitivity, we confirmed the high prevalence of the MYD88 L265P mutation in Korean LPL patients. Our study suggests the diagnostic value of MYD88 L265P for differentiating B-cell NHLs. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | Korean | - |
dc.publisher | Korea Society of Hematology | - |
dc.relation.isPartOf | BLOOD RESEARCH | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Detection of MYD88 L265P in patients with lymphoplasmacytic lymphoma/Waldenstrom macroglobulinemia and other B-cell non-Hodgkin lymphomas | - |
dc.type | Article | - |
dc.publisher.location | Korea | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Laboratory Medicine | - |
dc.contributor.googleauthor | Sang-Yong Shin | - |
dc.contributor.googleauthor | Seung-Tae Lee | - |
dc.contributor.googleauthor | Hyun-Young Kim | - |
dc.contributor.googleauthor | Chang-Hun Park | - |
dc.contributor.googleauthor | Hee-Jin Kim | - |
dc.contributor.googleauthor | Jong-Won Kim | - |
dc.contributor.googleauthor | Seok Jin Kim | - |
dc.contributor.googleauthor | Won Seog Kim | - |
dc.contributor.googleauthor | Sun-Hee Kim | - |
dc.identifier.doi | 10.5045/br.2016.51.3.181 | - |
dc.contributor.localId | A04627 | - |
dc.relation.journalcode | J00346 | - |
dc.identifier.eissn | 2288-0011 | - |
dc.relation.journalsince | 2013~ | - |
dc.identifier.pmid | 27722129 | - |
dc.relation.journalbefore | ~2012 Korean Journal of Hematology | - |
dc.contributor.alternativeName | Lee, Seung-Tae | - |
dc.contributor.affiliatedAuthor | Lee, Seung-Tae | - |
dc.citation.volume | 51 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 181 | - |
dc.citation.endPage | 186 | - |
dc.identifier.bibliographicCitation | BLOOD RESEARCH, Vol.51(3) : 181-186, 2016 | - |
dc.date.modified | 2017-10-24 | - |
dc.identifier.rimsid | 41037 | - |
dc.type.rims | ART | - |
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