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Detection of MYD88 L265P in patients with lymphoplasmacytic lymphoma/Waldenstrom macroglobulinemia and other B-cell non-Hodgkin lymphomas

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dc.contributor.author이승태-
dc.date.accessioned2017-10-26T08:09:04Z-
dc.date.available2017-10-26T08:09:04Z-
dc.date.issued2016-
dc.identifier.issn2287-979X-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/153032-
dc.description.abstractBACKGROUND: Recent studies have identified a high prevalence of the MYD88 L265P mutation in lymphoplasmacytic lymphoma (LPL)/Waldenstrom macroglobulinemia (WM) cases, whereas low frequencies have been observed in other B cell non-Hodgkin lymphomas (NHLs). METHODS: We evaluated the sensitivity of the mutant enrichment 3'-modified oligonucleotide (MEMO)-PCR technique, a new detection method. We examined the MYD88 L265P mutation in a series of Korean patients with LPL/WM and other B cell NHLs in bone marrow aspirates, using the MEMO-PCR technique. RESULTS: The sensitivity of MEMO-PCR was estimated to be approximately 10-16.7%. MYD88 L265P was detected in 21 of 28 LPL cases (75%) and only three of 69 B cell NHL cases (4.3%). CONCLUSION: Although MEMO-PCR had relatively low sensitivity, we confirmed the high prevalence of the MYD88 L265P mutation in Korean LPL patients. Our study suggests the diagnostic value of MYD88 L265P for differentiating B-cell NHLs.-
dc.description.statementOfResponsibilityopen-
dc.languageKorean-
dc.publisherKorea Society of Hematology-
dc.relation.isPartOfBLOOD RESEARCH-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleDetection of MYD88 L265P in patients with lymphoplasmacytic lymphoma/Waldenstrom macroglobulinemia and other B-cell non-Hodgkin lymphomas-
dc.typeArticle-
dc.publisher.locationKorea-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Laboratory Medicine-
dc.contributor.googleauthorSang-Yong Shin-
dc.contributor.googleauthorSeung-Tae Lee-
dc.contributor.googleauthorHyun-Young Kim-
dc.contributor.googleauthorChang-Hun Park-
dc.contributor.googleauthorHee-Jin Kim-
dc.contributor.googleauthorJong-Won Kim-
dc.contributor.googleauthorSeok Jin Kim-
dc.contributor.googleauthorWon Seog Kim-
dc.contributor.googleauthorSun-Hee Kim-
dc.identifier.doi10.5045/br.2016.51.3.181-
dc.contributor.localIdA04627-
dc.relation.journalcodeJ00346-
dc.identifier.eissn2288-0011-
dc.relation.journalsince2013~-
dc.identifier.pmid27722129-
dc.relation.journalbefore~2012 Korean Journal of Hematology-
dc.contributor.alternativeNameLee, Seung-Tae-
dc.contributor.affiliatedAuthorLee, Seung-Tae-
dc.citation.volume51-
dc.citation.number3-
dc.citation.startPage181-
dc.citation.endPage186-
dc.identifier.bibliographicCitationBLOOD RESEARCH, Vol.51(3) : 181-186, 2016-
dc.date.modified2017-10-24-
dc.identifier.rimsid41037-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers

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