Cited 14 times in
Review of clinical studies of perampanel in adolescent patients
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김흥동 | - |
dc.date.accessioned | 2017-10-26T08:08:41Z | - |
dc.date.available | 2017-10-26T08:08:41Z | - |
dc.date.issued | 2016 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/153025 | - |
dc.description.abstract | AIM: To assess the clinical trial and real-world data for adjunctive perampanel in adolescents and develop consensus recommendations to guide the use of perampanel in this population in clinical practice. METHODS: In May 2015, 15 epilepsy experts attended a Consensus Development Meeting to assess the clinical trial data for perampanel, specific to the adolescent age group (12-17 years) and develop consensus treatment recommendations. RESULTS AND DISCUSSION: Analysis of the adolescent subgroup data of three pivotal placebo-controlled, double-blind, phase 3 trials investigating perampanel in patients with ongoing focal epileptic seizures despite receiving one to three antiepileptic drugs found that perampanel 4-12 mg was superior to placebo. The tolerability profile of perampanel was generally acceptable. Adolescent patients receiving long-term treatment with perampanel in an open-label extension study maintained improvements in seizure control compared with baseline, with a favorable risk-benefit profile. A phase 2 study showed that perampanel had no clinically important effects on cognitive function, growth, and development. CONCLUSION: Perampanel is a welcome addition to the armamentarium of existing antiepileptic drugs as it represents a new approach in the management of epilepsy, with a novel mechanism of action, and the potential to have a considerable impact on the treatment of adolescents with epilepsy. | - |
dc.description.statementOfResponsibility | open | - |
dc.format | application/octet-stream | - |
dc.language | English | - |
dc.publisher | John Wiley & Sons | - |
dc.relation.isPartOf | BRAIN AND BEHAVIOR | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Review of clinical studies of perampanel in adolescent patients | - |
dc.type | Article | - |
dc.publisher.location | United States | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Pediatrics | - |
dc.contributor.googleauthor | Heung Dong Kim | - |
dc.contributor.googleauthor | Ching-Shiang Chi | - |
dc.contributor.googleauthor | Tayard Desudchit | - |
dc.contributor.googleauthor | Marina Nikanorova | - |
dc.contributor.googleauthor | Anannit Visudtibhan | - |
dc.contributor.googleauthor | Charcrin Nabangchang | - |
dc.contributor.googleauthor | Derrick W. S. Chan | - |
dc.contributor.googleauthor | Choong Yi Fong | - |
dc.contributor.googleauthor | Kai-Ping Chang | - |
dc.contributor.googleauthor | Shang-Yeong Kwan | - |
dc.contributor.googleauthor | Fe De Los Reyes | - |
dc.contributor.googleauthor | Chao-Ching Huang | - |
dc.contributor.googleauthor | Surachai Likasitwattanakul | - |
dc.contributor.googleauthor | Wang-Tso Lee | - |
dc.contributor.googleauthor | Ada Yung | - |
dc.contributor.googleauthor | Amitabh Dash | - |
dc.identifier.doi | 10.1002/brb3.505 | - |
dc.contributor.localId | A01208 | - |
dc.relation.journalcode | J02977 | - |
dc.identifier.eissn | 2162-3279 | - |
dc.relation.journalsince | 2011 | - |
dc.identifier.pmid | 27688936 | - |
dc.contributor.alternativeName | Kim, Heung Dong | - |
dc.contributor.affiliatedAuthor | Kim, Heung Dong | - |
dc.citation.volume | 6 | - |
dc.citation.number | 9 | - |
dc.citation.startPage | 00505 | - |
dc.identifier.bibliographicCitation | BRAIN AND BEHAVIOR, Vol.6(9) : 00505, 2016 | - |
dc.date.modified | 2017-10-24 | - |
dc.identifier.rimsid | 41031 | - |
dc.type.rims | ART | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.