125 80

Cited 7 times in

Review of clinical studies of perampanel in adolescent patients

DC FieldValueLanguage
dc.contributor.author김흥동-
dc.date.accessioned2017-10-26T08:08:41Z-
dc.date.available2017-10-26T08:08:41Z-
dc.date.issued2016-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/153025-
dc.description.abstractAIM: To assess the clinical trial and real-world data for adjunctive perampanel in adolescents and develop consensus recommendations to guide the use of perampanel in this population in clinical practice. METHODS: In May 2015, 15 epilepsy experts attended a Consensus Development Meeting to assess the clinical trial data for perampanel, specific to the adolescent age group (12-17 years) and develop consensus treatment recommendations. RESULTS AND DISCUSSION: Analysis of the adolescent subgroup data of three pivotal placebo-controlled, double-blind, phase 3 trials investigating perampanel in patients with ongoing focal epileptic seizures despite receiving one to three antiepileptic drugs found that perampanel 4-12 mg was superior to placebo. The tolerability profile of perampanel was generally acceptable. Adolescent patients receiving long-term treatment with perampanel in an open-label extension study maintained improvements in seizure control compared with baseline, with a favorable risk-benefit profile. A phase 2 study showed that perampanel had no clinically important effects on cognitive function, growth, and development. CONCLUSION: Perampanel is a welcome addition to the armamentarium of existing antiepileptic drugs as it represents a new approach in the management of epilepsy, with a novel mechanism of action, and the potential to have a considerable impact on the treatment of adolescents with epilepsy.-
dc.description.statementOfResponsibilityopen-
dc.formatapplication/octet-stream-
dc.languageEnglish-
dc.publisherJohn Wiley & Sons-
dc.relation.isPartOfBRAIN AND BEHAVIOR-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleReview of clinical studies of perampanel in adolescent patients-
dc.typeArticle-
dc.publisher.locationUnited States-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Pediatrics-
dc.contributor.googleauthorHeung Dong Kim-
dc.contributor.googleauthorChing-Shiang Chi-
dc.contributor.googleauthorTayard Desudchit-
dc.contributor.googleauthorMarina Nikanorova-
dc.contributor.googleauthorAnannit Visudtibhan-
dc.contributor.googleauthorCharcrin Nabangchang-
dc.contributor.googleauthorDerrick W. S. Chan-
dc.contributor.googleauthorChoong Yi Fong-
dc.contributor.googleauthorKai-Ping Chang-
dc.contributor.googleauthorShang-Yeong Kwan-
dc.contributor.googleauthorFe De Los Reyes-
dc.contributor.googleauthorChao-Ching Huang-
dc.contributor.googleauthorSurachai Likasitwattanakul-
dc.contributor.googleauthorWang-Tso Lee-
dc.contributor.googleauthorAda Yung-
dc.contributor.googleauthorAmitabh Dash-
dc.identifier.doi10.1002/brb3.505-
dc.contributor.localIdA01208-
dc.relation.journalcodeJ02977-
dc.identifier.eissn2162-3279-
dc.relation.journalsince2011-
dc.identifier.pmid27688936-
dc.contributor.alternativeNameKim, Heung Dong-
dc.contributor.affiliatedAuthorKim, Heung Dong-
dc.citation.volume6-
dc.citation.number9-
dc.citation.startPage00505-
dc.identifier.bibliographicCitationBRAIN AND BEHAVIOR, Vol.6(9) : 00505, 2016-
dc.date.modified2017-10-24-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아청소년과학교실) > 1. Journal Papers

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.