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Review of clinical studies of perampanel in adolescent patients

 Heung Dong Kim  ;  Ching-Shiang Chi  ;  Tayard Desudchit  ;  Marina Nikanorova  ;  Anannit Visudtibhan  ;  Charcrin Nabangchang  ;  Derrick W. S. Chan  ;  Choong Yi Fong  ;  Kai-Ping Chang  ;  Shang-Yeong Kwan  ;  Fe De Los Reyes  ;  Chao-Ching Huang  ;  Surachai Likasitwattanakul  ;  Wang-Tso Lee  ;  Ada Yung  ;  Amitabh Dash 
 BRAIN AND BEHAVIOR, Vol.6(9) : 00505, 2016 
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AIM: To assess the clinical trial and real-world data for adjunctive perampanel in adolescents and develop consensus recommendations to guide the use of perampanel in this population in clinical practice. METHODS: In May 2015, 15 epilepsy experts attended a Consensus Development Meeting to assess the clinical trial data for perampanel, specific to the adolescent age group (12-17 years) and develop consensus treatment recommendations. RESULTS AND DISCUSSION: Analysis of the adolescent subgroup data of three pivotal placebo-controlled, double-blind, phase 3 trials investigating perampanel in patients with ongoing focal epileptic seizures despite receiving one to three antiepileptic drugs found that perampanel 4-12 mg was superior to placebo. The tolerability profile of perampanel was generally acceptable. Adolescent patients receiving long-term treatment with perampanel in an open-label extension study maintained improvements in seizure control compared with baseline, with a favorable risk-benefit profile. A phase 2 study showed that perampanel had no clinically important effects on cognitive function, growth, and development. CONCLUSION: Perampanel is a welcome addition to the armamentarium of existing antiepileptic drugs as it represents a new approach in the management of epilepsy, with a novel mechanism of action, and the potential to have a considerable impact on the treatment of adolescents with epilepsy.
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1. College of Medicine (의과대학) > Dept. of Pediatrics (소아청소년과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Heung Dong(김흥동) ORCID logo https://orcid.org/0000-0002-8031-7336
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