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Hemangiopericytomas in the Central Nervous System: A Multicenter Study of Korean Cases with Validation of the Usage of STAT6 Immunohistochemistry for Diagnosis of Disease
DC Field | Value | Language |
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dc.contributor.author | 강석구 | - |
dc.contributor.author | 김세훈 | - |
dc.date.accessioned | 2017-10-26T08:08:03Z | - |
dc.date.available | 2017-10-26T08:08:03Z | - |
dc.date.issued | 2016 | - |
dc.identifier.issn | 1068-9265 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/153008 | - |
dc.description.abstract | BACKGROUND: Hemangiopericytoma (HPC) in the central nervous system (CNS) is a rare disease with distinctive biological/clinical characteristics compared with meningioma. METHODS: Cases of HPCs of the CNS were collected, and clinicopathological records were retrospectively reviewed and analyzed. Immunohistochemistry (IHC) for proliferative markers (Ki-67, PHH3) and STAT6 were performed. RESULTS: A total of 140 cases were collected, with mean follow-up of 77 months (median 58.8 months; range 0.53-540.5 months). 1-, 5-, 10-, and 20-year survival rates were 99.1, 94.0, 74.4, and 61.9 %, respectively. Thirty-nine patients (27.9 %) had recurrent disease. Mean and median times to recurrence were 62.9 and 47.3 months with 1-, 5-, 10-, and 20-year recurrence-free survival rates of 98.3, 78.3, 50.1, and 11.0 %, respectively. Thirteen patients (9.3 %) developed extracranial metastases. No adjuvant radiation therapy, higher histologic grades, failure of gross-total resection, and cases with gamma-knife surgery (GKS) were factors associated with shorter disease-free survival (log-rank test, p = 0.02, 0.00, 0.02, 0.00), among which high histologic grade and cases with GKS were significant in multivariable analysis. Strong nuclear STAT6 expression was noted in HPCs in 62 cases of HPCs (60/62, 96.8 %), whereas diffuse weak positivity was demonstrated in all meningioma cases. CONCLUSIONS: The survival rate in patients with HPC of the CNS is comparable to that of previously reported series. Recurrence remains a critical clinical issue of the disease. Identification of NAB2-STAT6 fusion transcript with surrogate IHC marker is a valuable diagnostic tool in the differential diagnosis of the disease. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.publisher | Springer | - |
dc.relation.isPartOf | ANNALS OF SURGICAL ONCOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Hemangiopericytomas in the Central Nervous System: A Multicenter Study of Korean Cases with Validation of the Usage of STAT6 Immunohistochemistry for Diagnosis of Disease | - |
dc.type | Article | - |
dc.publisher.location | United States | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Neurosurgery | - |
dc.contributor.googleauthor | Junjeong Choi | - |
dc.contributor.googleauthor | Sung-Hye Park | - |
dc.contributor.googleauthor | Shin Kwang Khang | - |
dc.contributor.googleauthor | Yeon-Lim Suh | - |
dc.contributor.googleauthor | Sang Pyo Kim | - |
dc.contributor.googleauthor | Youn Soo Lee | - |
dc.contributor.googleauthor | Hyun Seok Kwon | - |
dc.contributor.googleauthor | Seok-Gu Kang | - |
dc.contributor.googleauthor | Se Hoon Kim | - |
dc.identifier.doi | 10.1245/s10434-016-5414-x | - |
dc.contributor.localId | A00610 | - |
dc.contributor.localId | A00036 | - |
dc.relation.journalcode | J00179 | - |
dc.identifier.eissn | 1534-4681 | - |
dc.identifier.pmid | 27444109 | - |
dc.identifier.url | https://link.springer.com/article/10.1245%2Fs10434-016-5414-x | - |
dc.contributor.alternativeName | Kang, Seok Gu | - |
dc.contributor.alternativeName | Kim, Se Hoon | - |
dc.contributor.affiliatedAuthor | Kim, Se Hoon | - |
dc.contributor.affiliatedAuthor | Kang, Seok Gu | - |
dc.citation.volume | 23 | - |
dc.citation.number | Suppl. 5 | - |
dc.citation.startPage | 954 | - |
dc.citation.endPage | 961 | - |
dc.identifier.bibliographicCitation | ANNALS OF SURGICAL ONCOLOGY, Vol.23(Suppl. 5) : 954-961, 2016 | - |
dc.date.modified | 2017-10-24 | - |
dc.identifier.rimsid | 41016 | - |
dc.type.rims | ART | - |
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