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Biodistribution and Radiation Dosimetry of [18F]Mefway in Humans

DC FieldValueLanguage
dc.contributor.author류철형-
dc.contributor.author최재용-
dc.contributor.author유영훈-
dc.date.accessioned2017-10-26T08:07:15Z-
dc.date.available2017-10-26T08:07:15Z-
dc.date.issued2016-
dc.identifier.issn1536-1632-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/152984-
dc.description.abstractPURPOSE: [18F]Mefway is a positron emission tomography (PET) radioligand for quantification of the brain serotonin 1A (5-HT1A) receptor density. The purpose of this study was to evaluate the radiation safety of [18F]Mefway in humans. PROCEDURES: Six healthy volunteers (three males and three females) were whole-body PET scanned for 114 min after injection of [18F]Mefway (226?±?35 MBq). Estimated radiation doses were determined by the OLINDA/EXM software. RESULTS: [18F]Mefway was safe and well tolerated by all subjects. Residence time ranges from 0 (gallbladder) to 0.822 h (urinary bladder wall). While the estimated radiation doses in the reproductive and blood-forming organs were below 13.35-22.87 μSv/MBq, radiation dose in the urinary bladder wall was 471 μSv/MBq. The mean effective dose was 40.23?±?6.63 μSv/MBq. CONCLUSION: For a typical single injection of 185 MBq (5 mCi), the dose will result in 87.1 mSv for the urinary bladder wall. To reduce radiation burden, the bladder voiding can be used before [18F]Mefway PET scan.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherSpringer-
dc.relation.isPartOfMOLECULAR IMAGING AND BIOLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleBiodistribution and Radiation Dosimetry of [18F]Mefway in Humans-
dc.typeArticle-
dc.publisher.locationUnited States-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Neurology-
dc.contributor.googleauthorJae Yong Choi-
dc.contributor.googleauthorChul Hyoung Lyoo-
dc.contributor.googleauthorJin Su Kim-
dc.contributor.googleauthorKyeong Min Kim-
dc.contributor.googleauthorMinkyung Lee-
dc.contributor.googleauthorYoung Hoon Ryu-
dc.identifier.doi10.1007/s11307-016-0955-8-
dc.contributor.localIdA04695-
dc.contributor.localIdA02485-
dc.contributor.localIdA01333-
dc.relation.journalcodeJ02887-
dc.identifier.eissn1860-2002-
dc.identifier.pmid27126460-
dc.identifier.urlhttps://link.springer.com/article/10.1007%2Fs11307-016-0955-8-
dc.contributor.alternativeNameLyoo, Chul Hyoung-
dc.contributor.alternativeNameChoi, Jae Yong-
dc.contributor.alternativeNameRyu, Young Hoon-
dc.contributor.affiliatedAuthorChoi, Jae Yong-
dc.contributor.affiliatedAuthorRyu, Young Hoon-
dc.contributor.affiliatedAuthorLyoo, Chul Hyoung-
dc.citation.volume18-
dc.citation.number6-
dc.citation.startPage803-
dc.citation.endPage806-
dc.identifier.bibliographicCitationMOLECULAR IMAGING AND BIOLOGY, Vol.18(6) : 803-806, 2016-
dc.date.modified2017-10-24-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Nuclear Medicine (핵의학교실) > 1. Journal Papers

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