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Biodistribution and Radiation Dosimetry of [18F]Mefway in Humans

Authors
 Jae Yong Choi  ;  Chul Hyoung Lyoo  ;  Jin Su Kim  ;  Kyeong Min Kim  ;  Minkyung Lee  ;  Young Hoon Ryu 
Citation
 Molecular Imaging and Biology, Vol.18(6) : 803-806, 2016 
Journal Title
 Molecular Imaging and Biology 
ISSN
 1536-1632 
Issue Date
2016
Abstract
PURPOSE: [18F]Mefway is a positron emission tomography (PET) radioligand for quantification of the brain serotonin 1A (5-HT1A) receptor density. The purpose of this study was to evaluate the radiation safety of [18F]Mefway in humans. PROCEDURES: Six healthy volunteers (three males and three females) were whole-body PET scanned for 114 min after injection of [18F]Mefway (226?±?35 MBq). Estimated radiation doses were determined by the OLINDA/EXM software. RESULTS: [18F]Mefway was safe and well tolerated by all subjects. Residence time ranges from 0 (gallbladder) to 0.822 h (urinary bladder wall). While the estimated radiation doses in the reproductive and blood-forming organs were below 13.35-22.87 μSv/MBq, radiation dose in the urinary bladder wall was 471 μSv/MBq. The mean effective dose was 40.23?±?6.63 μSv/MBq. CONCLUSION: For a typical single injection of 185 MBq (5 mCi), the dose will result in 87.1 mSv for the urinary bladder wall. To reduce radiation burden, the bladder voiding can be used before [18F]Mefway PET scan.
Full Text
https://link.springer.com/article/10.1007%2Fs11307-016-0955-8
DOI
10.1007/s11307-016-0955-8
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Nuclear Medicine (핵의학교실)
Yonsei Authors
류철형(Lyoo, Chul Hyoung)
유영훈(Ryu, Young Hoon)
최재용(Choi, Jae Yong)
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/152984
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