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Feasibility of test-bolus DCE-MRI using CAIPIRINHA-VIBE for the evaluation of pancreatic malignancies

 Jimi Huh  ;  Yoonseok Choi  ;  Dong-Cheol Woo  ;  Nieun Seo  ;  Bohyun Kim  ;  Chang Kyung Lee  ;  In Seong Kim  ;  Dominik Nickel  ;  Kyung Won Kim 
 EUROPEAN RADIOLOGY, Vol.26(11) : 3949-3956, 2016 
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OBJECTIVES: To evaluate the feasibility of test-bolus dynamic contrast-enhanced (DCE) MRI with CAIPIRINHA-VIBE for pancreatic malignancies. METHODS: Thirty-two patients underwent DCE-MRI with CAIPIRINHA-VIBE after injection of 2 mL gadolinium. From the resulting time-intensity curve (TIC), we estimated the arterial (AP) and portal venous phase (PVP) scan timing for subsequent multiphasic MRI. DCE-MRI perfusion maps were generated, and perfusion parameters were calculated. The image quality was rated on a 5-point scale (1: poor, 5: excellent). Goodness-of-fit of the TIC was evaluated by Pearson's χ2 test. RESULTS: Test-bolus DCE-MRIs with high temporal (3 s) and spatial resolution (1?×?1?×?4 mm3) were acquired with good-quality perfusion maps of Ktrans and iAUC (mean score 4.313?±?0.535 and 4.125?±?0.554, respectively). The mean χ2 values for fitted TICs were 0.115?±?0.082 for the pancreatic parenchyma and 0.784?±?0.074 for pancreatic malignancies, indicating an acceptable goodness-of-fit. Test-bolus DCE-MRI was highly accurate in estimating the proper timing of AP (90.6 %) and PVP (100 %) of subsequent multiphasic MRI. Between pancreatic adenocarcinomas and neuroendocrine tumours, there were significant differences in the Ktrans (0.073?±?0.058 vs. 0.308?±?0.062, respectively; p?=?0.007) and iAUC (1.501?±?0.828 vs. 3.378?±?0.378, respectively; p?=?0.045). CONCLUSIONS: Test-bolus DCE-MRI using CAIPIRINHA-VIBE is feasible for incorporating perfusion analysis of pancreatic tumours into routine multiphasic MRI. KEY POINTS: ? Test-bolus DCE-MRI using CAIPIRINHA-VIBE is feasible for perfusion analysis of pancreatic tumours. ? CAIPIRINHA-VIBE enables DCE-MRI with high temporal and spatial resolution. ? Test-bolus DCE-MRI is highly accurate in estimating the proper timing of multiphasic MRI.
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1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
Yonsei Authors
Seo, Nieun(서니은) ORCID logo https://orcid.org/0000-0001-8745-6454
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