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Occupational exposure to crystalline silica and gastric cancer: a systematic review and meta-analysis

Authors
 Wanhyung Lee  ;  Yeon-Soon Ahn  ;  Seunghyun Lee  ;  Bo Mi Song  ;  Seri Hong  ;  Jin-Ha Yoon 
Citation
 OCCUPATIONAL AND ENVIRONMENTAL MEDICINE, Vol.73(11) : 794-801, 2016 
Journal Title
OCCUPATIONAL AND ENVIRONMENTAL MEDICINE
ISSN
 1351-0711 
Issue Date
2016
Abstract
Crystalline silica is a widely used industrial material that is readily available worldwide, and is one of the most common types of particulate mineral pollutants. It has been classified as a group 1 human carcinogen of the respiratory system; however, whether it is linked to gastric cancer remains uncertain. We conducted a systemic review and meta-analyses to search for evidence of the relationship between gastric cancer and occupational exposure to crystalline silica. We searched for articles on occupations involving silica exposure and gastric cancer studies up to December 2014. Pooled-risk estimates of the association between occupational crystalline silica exposure and risk of gastric cancer were calculated by a random effects model. Metaregression analyses of industry type and histological confirmation status, study design and industrial subgroup analyses were performed. 29 articles, including 9 case-control and 20 cohort studies, were analysed. The overall summary effects size was 1.25 (95% CI 1.18 to 1.34) for the association of occupational silica exposure with gastric cancer. Both heterogeneity and publication bias were partially attenuated after subgroup analyses. Heterogeneity of studies was attenuated after metaregression by industry. Higher overall effects were observed in the mining and foundry industries. We found a significant relationship between occupational crystalline silica exposure and gastric cancer. Our results were strengthened by various subgroup analyses and, considering the biological plausibility of our premise, further studies are required to better understand this association.
Full Text
http://oem.bmj.com/content/73/11/794.long
DOI
10.1136/oemed-2016-103552
Appears in Collections:
4. Graduate School of Public Health (보건대학원) > Graduate School of Public Health (보건대학원) > 1. Journal Papers
1. College of Medicine (의과대학) > Research Institute (부설연구소) > 1. Journal Papers
Yonsei Authors
Yoon, Jin Ha(윤진하) ORCID logo https://orcid.org/0000-0003-4198-2955
Lee, Wan Hyung(이완형)
Hong, Se Ri(홍세리)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/152948
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