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The long noncoding RNA HOXA11 antisense induces tumor progression and stemness maintenance in cervical cancer

DC FieldValueLanguage
dc.contributor.author김건홍-
dc.contributor.author김상운-
dc.contributor.author김영태-
dc.contributor.author남은지-
dc.contributor.author어경진-
dc.contributor.author윤선옥-
dc.date.accessioned2017-10-26T08:05:03Z-
dc.date.available2017-10-26T08:05:03Z-
dc.date.issued2016-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/152926-
dc.description.abstractRecent research has focused on the impact of long noncoding RNA (lncRNA) in cervical carcinogenesis. However, whether HOXA11 antisense (HOXA11-AS) is involved in cervical cancer remains to be elucidated. In the present study, we examined HOXA11-AS expression levels in cervical cancer patients and determined the relationships between HOXA11-AS expression and clinicopathological factors. We also investigated the bio-functional consequences of HOXA11-AS overexpression both in vitro and in vivo. HOXA11-AS expression was significantly greater in tissues from patients with cervical cancer than in control patients (P<0.001). Multivariate analysis showed that high HOXA11-AS was an independent prognosticator of overall survival (Hazard ratio=2.450, P=0.032). HOXA11-AS overexpression enhanced cell proliferation, migration, and tumor invasion in vitro, whereas HOXA11-AS knockdown inhibited these biologic aggressive features. These adverse changes were accompanied by characteristics of epithelial-mesenchymal transition (EMT). In vivo xenograft experiments using the siHOXA11-AS-transfected HeLa cells revealed that HOXA11-AS strongly induced tumor growth. Furthermore, we found that HOXA11-AS knockdown decreased cancer stemness and triggered the EMT program. In conclusion, HOXA11-AS overexpression correlated with poor survival in patients with cervical cancer. Thus, HOXA11-AS may be a pivotal target for exploring novel cervical cancer therapeutics.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherImpact Journals-
dc.relation.isPartOfONCOTARGET-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleThe long noncoding RNA HOXA11 antisense induces tumor progression and stemness maintenance in cervical cancer-
dc.typeArticle-
dc.publisher.locationUnited States-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Biochemistry & Molecular Biology-
dc.contributor.googleauthorHee Jung Kim-
dc.contributor.googleauthorKyung Jin Eoh-
dc.contributor.googleauthorLee Kyung Kim-
dc.contributor.googleauthorEun Ji Nam-
dc.contributor.googleauthorSun Och Yoon-
dc.contributor.googleauthorKun-Hong Kim-
dc.contributor.googleauthorJae Kwan Lee-
dc.contributor.googleauthorSang Wun Kim-
dc.contributor.googleauthorYoung Tae Kim-
dc.identifier.doi10.18632/oncotarget.12863-
dc.contributor.localIdA00526-
dc.contributor.localIdA00729-
dc.contributor.localIdA01262-
dc.contributor.localIdA04842-
dc.contributor.localIdA02566-
dc.contributor.localIdA00289-
dc.relation.journalcodeJ02421-
dc.identifier.eissn1949-2553-
dc.identifier.pmid27792998-
dc.contributor.alternativeNameKim, Kun Hong-
dc.contributor.alternativeNameKim, Sang Wun-
dc.contributor.alternativeNameKim, Young Tae-
dc.contributor.alternativeNameNam, Eun Ji-
dc.contributor.alternativeNameEoh, Kyung Jin-
dc.contributor.alternativeNameYoon, Sun Och-
dc.contributor.affiliatedAuthorKim, Sang Wun-
dc.contributor.affiliatedAuthorKim, Young Tae-
dc.contributor.affiliatedAuthorNam, Eun Ji-
dc.contributor.affiliatedAuthorEoh, Kyung Jin-
dc.contributor.affiliatedAuthorYoon, Sun Och-
dc.contributor.affiliatedAuthorKim, Kun Hong-
dc.citation.volume7-
dc.citation.number50-
dc.citation.startPage83001-
dc.citation.endPage83016-
dc.identifier.bibliographicCitationONCOTARGET , Vol.7(50) : 83001-83016, 2016-
dc.date.modified2017-10-24-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Biochemistry and Molecular Biology (생화학-분자생물학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Obstetrics and Gynecology (산부인과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers

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