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Lysophosphatidic acid activates the RhoA and NF-κB through Akt/IκBα signaling and promotes prostate cancer invasion and progression by enhancing functional invadopodia formation
DC Field | Value | Language |
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dc.contributor.author | 장향란 | - |
dc.date.accessioned | 2017-10-26T08:03:52Z | - |
dc.date.available | 2017-10-26T08:03:52Z | - |
dc.date.issued | 2016 | - |
dc.identifier.issn | 1010-4283 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/152897 | - |
dc.description.abstract | We have demonstrated previously that increased RhoA and nuclear factor (NF)-κB activities are associated with increased PC-3 prostate cancer cell invasion and that lysophosphatidic acid (LPA) significantly increases cancer invasion through RhoA and NF-κB activation. In this study, we identified the intermediate signaling molecules and specialized cell structures which are activated by LPA, resulting in enhanced cellular invasion. LPA-induced Akt and IκBα signaling pathways were necessary for RhoA and NF-κB activation, and these LPA effects were abolished by RhoA inhibition. Mice injected with PC-3 cells expressing dominant-negative RhoA N19 developed significantly less tumor growth compared with those injected with control (pcDNA 3.1). In addition, LPA treatment increased functional invadopodia formation. Activation of RhoA and NF-κB through the Akt and IκBα signaling pathway was required for LPA-stimulated gelatin degradation activity. LPA administration increased tumor growth and osteolytic lesions in a mouse xenograft model. These results indicate that LPA promotes PC-3 cell invasion by increasing functional invadopodia formation via upregulating RhoA and NF-κB signaling which contributes to prostate cancer progression. Therefore, the LPA and RhoA-NF-κB signaling axis may represent key molecular targets to inhibit prostate cancer invasion and progression. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Springer Netherlands | - |
dc.relation.isPartOf | TUMOR BIOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Lysophosphatidic acid activates the RhoA and NF-κB through Akt/IκBα signaling and promotes prostate cancer invasion and progression by enhancing functional invadopodia formation | - |
dc.type | Article | - |
dc.publisher.location | Netherlands | - |
dc.contributor.college | Research Institutes | - |
dc.contributor.department | Oral Cancer Research Institute | - |
dc.contributor.googleauthor | Young Sun Hwang | - |
dc.contributor.googleauthor | Jongsung Lee | - |
dc.contributor.googleauthor | Xianglan Zhang | - |
dc.contributor.googleauthor | Paul F. Lindholm | - |
dc.identifier.doi | 10.1007/s13277-015-4549-x | - |
dc.contributor.localId | A03489 | - |
dc.relation.journalcode | J02763 | - |
dc.identifier.eissn | 1423-0380 | - |
dc.identifier.pmid | 26662305 | - |
dc.identifier.url | https://link.springer.com/article/10.1007%2Fs13277-015-4549-x | - |
dc.contributor.alternativeName | Zhang, Xiang Lan | - |
dc.contributor.affiliatedAuthor | Zhang, Xiang Lan | - |
dc.citation.volume | 37 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 6775 | - |
dc.citation.endPage | 6785 | - |
dc.identifier.bibliographicCitation | TUMOR BIOLOGY, Vol.37(5) : 6775-6785, 2016 | - |
dc.date.modified | 2017-10-24 | - |
dc.identifier.rimsid | 40521 | - |
dc.type.rims | ART | - |
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