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Risk factors associated with early mortality in patients with multiple myeloma who were treated upfront with a novel agents containing regimen

 Sung-Hoon Jung  ;  Min-Seok Cho  ;  Hee Kyung Kim  ;  Seok Jin Kim  ;  Kihyun Kim  ;  June-Won Cheong  ;  Soo-Jeoong Kim  ;  Jin Seok Kim  ;  Jae-Sook Ahn  ;  Yeo-Kyeoung Kim  ;  Deok-Hwan Yang  ;  Hyeoung-Joon Kim  ;  Je-Jung Lee 
 BMC CANCER, Vol.16 : 613, 2016 
Journal Title
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BACKGROUND: Although the introduction of novel agents improved the survival outcomes in patients with multiple myeloma (MM), some patients died within one year (early mortality, EM) following diagnosis. In this study, we evaluated the EM rate, and investigated the risk factors associated with EM in MM patients. METHODS: Retrospective data from 542 patients who were initially treated with a novel agent-containing regimen were analyzed. RESULTS: The median overall survival (OS) for the entire cohort was 56.5 months. The median OS in the 2010-2014 group was longer than in the 2002-2009 group (59.2 months vs. 49.1 months, P?=?0.054). The rate of EM was 13.8 %, and the most common causes of EM were infection and comorbidity. In multivariate analysis, the age-adjusted Charlson comorbidity index (ACCI?≥?4), low body mass index (BMI?<?20 kg/m(2)), thrombocytopenia, and renal failure were significantly associated with EM. The presence of none, 1, or?≥?2 factors was associated with a 4.1 %, 14.3 %, or 27.4 % risk of EM (P?<?0.001), respectively. The median OS times were significantly different depending on the presence of factors associated with EM (P?<?0.001). CONCLUSIONS: In conclusion, the ACCI (≥?4), low BMI, thrombocytopenia and renal failure were strong predictors for EM in the novel agent era. The results of this study will help to identify patients at high risk for EM, and may be helpful to more accurately predict prognosis of MM patients in the novel-agent era.
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1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Soo Jeong(김수정) ORCID logo https://orcid.org/0000-0001-8859-3573
Kim, Jin Seok(김진석) ORCID logo https://orcid.org/0000-0001-8986-8436
Cheong, June-Won(정준원) ORCID logo https://orcid.org/0000-0002-1744-0921
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