Cited 21 times in
Immune adjuvant effect of a Toxoplasma gondii profilin-like protein in autologous whole-tumor-cell vaccination in mice
DC Field | Value | Language |
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dc.contributor.author | 표경호 | - |
dc.date.accessioned | 2017-10-26T08:01:21Z | - |
dc.date.available | 2017-10-26T08:01:21Z | - |
dc.date.issued | 2016 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/152833 | - |
dc.description.abstract | Profilin-like protein in Toxoplasma gondii (TgPLP) is a Toll-like receptor (TLR) agonist. In this study, we investigated whether TgPLP has an adjuvant effect on immune function in autologous whole-tumor-cell vaccine (AWV) treatment. Mice vaccinated with AWV together with recombinant TgPLP protein had smaller CT26 tumors and increased survival. TgPLP treatment strongly increased the production of IL-12 through MyD88 signaling and several chemokines, including CCL5, CCL12, and XCL1, in bone marrow-derived macrophages (BMMs). In addition, TgPLP increased the phagocytosis of tumor cells by BMMs and promoted immune cell mobility on a tumor-matrigel scaffold. TgPLP triggered immune responses as demonstrated by increased expression of antigen presenting cell markers (MHC class I and II, B7.1, and B7.2) in BMMs and increased IL-12 and IFN-γ expression in mice. Mice vaccinated with AWV and TgPLP had more immune cells (CD4+ and CD8+ T cells, natural killer cells, and macrophages) in the spleen and higher total IgG and IgG2a concentrations in the blood than mice vaccinated with AWV alone. These findings suggest that TgPLP is a TLR-based vaccine adjuvant that enhances antitumor immune responses during vaccination with AWV. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Impact Journals | - |
dc.relation.isPartOf | ONCOTARGET | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Immune adjuvant effect of a Toxoplasma gondii profilin-like protein in autologous whole-tumor-cell vaccination in mice | - |
dc.type | Article | - |
dc.publisher.location | United States | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Life Science | - |
dc.contributor.googleauthor | Kyoung-Ho Pyo | - |
dc.contributor.googleauthor | You-Won Lee | - |
dc.contributor.googleauthor | Sun Min Lim | - |
dc.contributor.googleauthor | Eun-Hee Shin | - |
dc.identifier.doi | 10.18632/oncotarget.12316 | - |
dc.contributor.localId | A04809 | - |
dc.relation.journalcode | J02421 | - |
dc.identifier.eissn | 1949-2553 | - |
dc.identifier.pmid | 27687589 | - |
dc.contributor.alternativeName | Pyo, Kyoung Ho | - |
dc.contributor.affiliatedAuthor | Pyo, Kyoung Ho | - |
dc.citation.volume | 7 | - |
dc.citation.number | 45 | - |
dc.citation.startPage | 74107 | - |
dc.citation.endPage | 74119 | - |
dc.identifier.bibliographicCitation | ONCOTARGET , Vol.7(45) : 74107-74119, 2016 | - |
dc.date.modified | 2017-10-24 | - |
dc.identifier.rimsid | 40463 | - |
dc.type.rims | ART | - |
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