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Half-Fan-Based Intensity-Weighted Region-of-Interest Imaging for Low-Dose Cone-Beam CT in Image-Guided Radiation Therapy

DC FieldValueLanguage
dc.contributor.author김진성-
dc.date.accessioned2017-10-26T07:59:51Z-
dc.date.available2017-10-26T07:59:51Z-
dc.date.issued2016-
dc.identifier.issn2093-3681-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/152797-
dc.description.abstractOBJECTIVES: With the increased use of computed tomography (CT) in clinics, dose reduction is the most important feature people seek when considering new CT techniques or applications. We developed an intensity-weighted region-of-interest (IWROI) imaging method in an exact half-fan geometry to reduce the imaging radiation dose to patients in cone-beam CT (CBCT) for image-guided radiation therapy (IGRT). While dose reduction is highly desirable, preserving the high-quality images of the ROI is also important for target localization in IGRT. METHODS: An intensity-weighting (IW) filter made of copper was mounted in place of a bowtie filter on the X-ray tube unit of an on-board imager (OBI) system such that the filter can substantially reduce radiation exposure to the outer ROI. In addition to mounting the IW filter, the lead-blade collimation of the OBI was adjusted to produce an exact half-fan scanning geometry for a further reduction of the radiation dose. The chord-based rebinned backprojection-filtration (BPF) algorithm in circular CBCT was implemented for image reconstruction, and a humanoid pelvis phantom was used for the IWROI imaging experiment. RESULTS: The IWROI image of the phantom was successfully reconstructed after beam-quality correction, and it was registered to the reference image within an acceptable level of tolerance. Dosimetric measurements revealed that the dose is reduced by approximately 61% in the inner ROI and by 73% in the outer ROI compared to the conventional bowtie filter-based half-fan scan. CONCLUSIONS: The IWROI method substantially reduces the imaging radiation dose and provides reconstructed images with an acceptable level of quality for patient setup and target localization. The proposed half-fan-based IWROI imaging technique can add a valuable option to CBCT in IGRT applications.-
dc.description.statementOfResponsibilityopen-
dc.languageKorean-
dc.publisherKorean Society of Medical Informatics-
dc.relation.isPartOfHEALTHCARE INFORMATICS RESEARCH-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleHalf-Fan-Based Intensity-Weighted Region-of-Interest Imaging for Low-Dose Cone-Beam CT in Image-Guided Radiation Therapy-
dc.typeArticle-
dc.publisher.locationKorea-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Radiation Oncology-
dc.contributor.googleauthorBoyeol Yoo-
dc.contributor.googleauthorKihong Son-
dc.contributor.googleauthorRizza Pua-
dc.contributor.googleauthorJinsung Kim-
dc.contributor.googleauthorAlexander Solodov-
dc.contributor.googleauthorSeungryong Cho-
dc.identifier.doi10.4258/hir.2016.22.4.316-
dc.contributor.localIdA04548-
dc.relation.journalcodeJ00974-
dc.identifier.eissn2093-369X-
dc.relation.journalsince2010~-
dc.identifier.pmid27895964-
dc.relation.journalbefore~2009 Journal of Korean Society of Medical Informatics (대한의료정보학회지)-
dc.subject.keywordCone-Beam Computed Tomography-
dc.subject.keywordHalf-Fan-
dc.subject.keywordImage-Guided Radiation Therapy-
dc.subject.keywordLow-Dose-
dc.subject.keywordRegion-of-Interest-
dc.contributor.alternativeNameKim, Jinsung-
dc.contributor.affiliatedAuthorKim, Jinsung-
dc.citation.volume22-
dc.citation.number4-
dc.citation.startPage316-
dc.citation.endPage325-
dc.identifier.bibliographicCitationHEALTHCARE INFORMATICS RESEARCH, Vol.22(4) : 316-325, 2016-
dc.date.modified2017-10-24-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiation Oncology (방사선종양학교실) > 1. Journal Papers

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