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Development of novel photopolymerizable hyaluronic acid/heparin-based hydrogel scaffolds with a controlled release of growth factors for enhanced bone regeneration

Authors
 Min Soo Bae  ;  Na Re Ko  ;  Sang Jin Lee  ;  Jung Bok Lee  ;  Dong Nyoung Heo  ;  Wook Byun  ;  Byung-Joon Choi  ;  Hoon Bong Jeon  ;  Hee-Jae Jang  ;  Ji-Yoon Ahn  ;  Deok-Sang Hwang  ;  Bock-Young Jung  ;  Il Keun Kwon 
Citation
 MACROMOLECULAR RESEARCH, Vol.24(9) : 829-837, 2016 
Journal Title
MACROMOLECULAR RESEARCH
ISSN
 1598-5032 
Issue Date
2016
Keywords
photopolymerization ; hyaluronic acid ; heparin ; hydrogel ; growth factor ; bone tissue regeneration
Abstract
In this study, the effect of novel BMP-2-loaded photo-cured hydrogels on in vitro and in vivo osteogenesis were explored. The well-defined HA-heparin hydrogel was prepared by a photopolymerization of aminoethyl methacrylate (AEMA) grafted hyaluronic acid (HA) and AEMA-grafted heparin. Subsequently, the resulting hydrogels contained BMP-2 at different concentrations. First, a series of BMP-2-loaded hydrogels were characterized to determine their mechanical properties and release profiles. The results from rheology, swelling ratio, and release kinetics suggest that BMP-2 contained HA-g-Hhep gel (B/HA-g-Hhep gel) had sustained release during 4 weeks with minimal initial burst. Furthermore, the released BMP-2 maintained its biological activity. MTT and live/dead assays showed that the B/HA-g-Hhep gel had good biocompatibility to be used as a scaffold for bone regeneration. In vivo studies of B/HA-g-Hhep gel exhibited significantly enhanced osteogenesis, compared with other types of HA-heparin hydrogels. These excellent results indicated that B/HA-g-Hhep gel has a great potential for a controlled release of growth factor, leading to a good bone regeneration.
Full Text
https://link.springer.com/article/10.1007%2Fs13233-016-4112-7
DOI
10.1007/s13233-016-4112-7
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Advanced General Dentistry (통합치의학과) > 1. Journal Papers
Yonsei Authors
Jung, Bok Yeong(정복영) ORCID logo https://orcid.org/0000-0002-8186-2109
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/152765
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