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Shear-Wave Elastography for Papillary Thyroid Carcinoma can Improve Prediction of Cervical Lymph Node Metastasis

 Ah Young Park  ;  Jeong-Ah Kim  ;  Eun Ju Son  ;  Ji Hyun Youk 
 ANNALS OF SURGICAL ONCOLOGY, Vol.23(Suppl. 5) : 722-729, 2016 
Journal Title
Issue Date
Adolescent ; Adult ; Aged ; Area Under Curve ; Carcinoma, Papillary/diagnostic imaging* ; Carcinoma, Papillary/secondary* ; Carcinoma, Papillary/surgery ; Elasticity ; Elasticity Imaging Techniques/methods* ; Female ; Humans ; Lymphatic Metastasis ; Male ; Middle Aged ; Neck ; Neck Dissection ; Neoplasm Staging ; Predictive Value of Tests ; Preoperative Period ; Retrospective Studies ; Thyroid Neoplasms/diagnostic imaging* ; Thyroid Neoplasms/pathology* ; Thyroid Neoplasms/surgery ; Young Adult
Lymph Node Metastasis ; Thyroid Cancer ; Paillary Thyroid Carcinoma ; Cervical Lymph Node Metastasis ; Lateral Lymph Node Metastasis
BACKGROUND: This study aimed to investigate whether the elasticity index of shear-wave elastography (SWE) can predict cervical lymph node (LN) metastasis of papillary thyroid carcinoma (PTC). METHODS: This retrospective study included 363 patients with a surgical diagnosis of PTC who underwent preoperative SWE evaluation. The elasticity indices of PTC (E mean, E max, E min, E ratio-p, and E ratio-m) and gray-scale ultrasound (US) parameters (extrathyroidal extension, multifocality, and cervical LN metastasis) were correlated with the pathologic staging parameters. The optimal cutoff values for the elasticity indices were determined for the prediction of cervical LN metastasis, and diagnostic performance was compared between gray-scale US and the combined application of gray-scale US and SWE. RESULTS: The findings showed E mean and E max to be associated with central LN metastasis (P = 0.037) and E min to be associated with lateral LN metastasis (P = 0.015). An E mean value higher than 124 kPa or an E max value higher than 138 kPa with suspicious gray-scale US findings improved the sensitivity and area under the curve (AUC) for predicting central LN metastasis (sensitivity, 45.4 and 44.6 % vs. 28 %, P < 0.001; AUC, 0.659 and 0.667 vs. 0.615, P = 0.011 and 0.019), whereas an E min value higher than 63 kPa with suspicious gray-scale US findings improved the sensitivity and AUC for predicting lateral LN metastasis (sensitivity, 95.8 vs. 75 %, P = 0.025; AUC, 0.924 vs. 0.871, P = 0.047). CONCLUSION: The quantitative elasticity index of PTC on preoperative SWE could be useful for predicting cervical LN metastasis.
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1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Jeong Ah(김정아) ORCID logo https://orcid.org/0000-0003-4949-4913
Son, Eun Ju(손은주) ORCID logo https://orcid.org/0000-0002-7895-0335
Youk, Ji Hyun(육지현) ORCID logo https://orcid.org/0000-0002-7787-780X
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