0 484

Cited 57 times in

Type I Interferon Regulates the Placental Inflammatory Response to Bacteria and is Targeted by Virus: Mechanism of Polymicrobial Infection-Induced Preterm Birth

DC Field Value Language
dc.contributor.author권자영-
dc.date.accessioned2017-10-26T07:56:21Z-
dc.date.available2017-10-26T07:56:21Z-
dc.date.issued2016-
dc.identifier.issn1046-7408-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/152715-
dc.description.abstractPROBLEM: Preterm birth (PTB) affects approximately 12% of pregnancies and at least 50% of cases have no known risk factors. We hypothesize that subclinical viral infections of the placenta are a factor sensitizing women to intrauterine bacterial infection. Specifically, we propose that viral-induced placental IFN-β inhibition results in a robust inflammatory response to low concentrations of bacteria. METHODS: Human trophoblast SW.71, C57BL/6, and interferon (IFN) receptor knockout animals were used to determine IFN function. Illumina and Bio-Rad microarrays identified pathways. RESULTS: Inhibiting the IFN-β pathway resulted in a significant increase in inflammatory cytokines such as IL-1B in response to LPS. Twist was positively correlated with IFN-β expression and STAT3 phosphorylation and overexpressing Twist reduced IL-1B. Treating IFNAR-/- mice with low-dose LPS at E15.5 caused preterm birth. CONCLUSION: IFN-β was identified as a key modulator of placental inflammation and, importantly, is commonly affected by viruses. We propose dysregulation of IFN-β is a major determinant for preterm birth associated with polymicrobial infection.-
dc.description.statementOfResponsibilityrestriction-
dc.publisherWiley-Blackwell-
dc.relation.isPartOfAMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleType I Interferon Regulates the Placental Inflammatory Response to Bacteria and is Targeted by Virus: Mechanism of Polymicrobial Infection-Induced Preterm Birth-
dc.typeArticle-
dc.publisher.locationDenmark-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Obstetrics & Gynecology-
dc.contributor.googleauthorKaren Racicot-
dc.contributor.googleauthorJa Young Kwon-
dc.contributor.googleauthorPaulomi Aldo-
dc.contributor.googleauthorVikki Abrahams-
dc.contributor.googleauthorAyman El-Guindy-
dc.contributor.googleauthorRoberto Romero-
dc.contributor.googleauthorGil Mor-
dc.identifier.doi10.1111/aji.12501-
dc.contributor.localIdA00246-
dc.relation.journalcodeJ00111-
dc.identifier.eissn1600-0897-
dc.identifier.pmid26892235-
dc.identifier.urlhttp://onlinelibrary.wiley.com/doi/10.1111/aji.12501/abstract-
dc.contributor.alternativeNameKwon, Ja Young-
dc.contributor.affiliatedAuthorKwon, Ja Young-
dc.citation.volume75-
dc.citation.number4-
dc.citation.startPage451-
dc.citation.endPage460-
dc.identifier.bibliographicCitationAMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY, Vol.75(4) : 451-460, 2016-
dc.date.modified2017-10-24-
dc.identifier.rimsid39723-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Obstetrics and Gynecology (산부인과학교실) > 1. Journal Papers

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.