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Magnetic Nanovector Enabling miRNA-34a Delivery for CD44 Suppression with Concurrent MR Imaging

Authors
 Lee, Hwunjae  ;  Kim, Hyun-Ouk  ;  Son, Hye-Young  ;  Lee, Sang-Bock  ;  Jang, Eunji  ;  Kang, Byunghoon  ;  Haam, Seungjoo  ;  Lim, Eun-Kyung  ;  Huh, Yong-Min 
Citation
 Journal of Nanoscience and Nanotechnology, Vol.16(12) : 12939-12946, 2016 
Journal Title
 Journal of Nanoscience and Nanotechnology 
ISSN
 1533-4880 
Issue Date
2016
Abstract
We report the development of a microRNA (miRNA)-based theragnostic system that can facilitate simple therapeutic miRNA-34a delivery and visualization by high-resolution magnetic resonance (MR) imaging. Magnetic nanovectors were formed by directly attaching miRNA-34a to the surface of magnetic nanoparticles (MNPs), modified nitrosonium tetrafluoroborate (NOBF4) and subsequently introduced polyethylene glycol (PEG) molecules for high stability in an aqueous phase. The miRNA-34a?conjugated magnetic nanovectors showed therapeutic effects, inhibiting cellular migration and invasion through CD44 gene suppression; they also exhibited a strong MR signal. These results demonstrate that magnetic nanovectors have potential as theragnostic nanosystems for miRNA-based cancer therapy.
Full Text
http://www.ingentaconnect.com/contentone/asp/jnn/2016/00000016/00000012/art00138
DOI
10.1166/jnn.2016.13797
Appears in Collections:
1. College of Medicine (의과대학) > BioMedical Science Institute (의생명과학부) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
Yonsei Authors
손혜영(Son, Hye Yeong) ORCID logo https://orcid.org/0000-0001-5977-6784
허용민(Huh, Yong Min) ORCID logo https://orcid.org/0000-0002-9831-4475
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/152703
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