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From cell biology to immunology: Controlling metastatic progression of cancer via microRNA regulatory networks

Authors
 Jae Hyon Park  ;  Evropi Theodoratou  ;  George A. Calin  ;  Jae Il Shin 
Citation
 ONCOIMMUNOLOGY, Vol.5(11) : 1230579, 2016 
Journal Title
ONCOIMMUNOLOGY
ISSN
 2162-4011 
Issue Date
2016
Abstract
Recently, the study of microRNAs has expanded our knowledge of the fundamental processes of cancer biology and the underlying mechanisms behind tumor metastasis. Extensive research in the fields of microRNA and its novel mechanisms of actions against various cancers has more recently led to the trial of a first cancer-targeted microRNA drug, MRX34. Yet, these microRNAs are mostly being studied and clinically trialed solely based on the understanding of their cell biologic effects, thus, neglecting the important immunologic effects that are sometimes opposite of the cell biologic effects. Here, we summarize both the cell biologic and immunologic effects of various microRNAs and discuss the importance of considering both effects before using them in clinical settings. We stress the importance of understanding the miRNA's effect on cancer metastasis from a "systems" perspective before developing a miRNA-targeted therapeutic in treating cancer metastasis.
Full Text
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5139645/
DOI
10.1080/2162402X.2016.1230579
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아과학교실) > 1. Journal Papers
Yonsei Authors
Shin, Jae Il(신재일) ORCID logo https://orcid.org/0000-0003-2326-1820
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/152696
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