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Juvenile Myasthenia Gravis in Korea: Subgroup Analysis According to Sex and Onset Age

Authors
 Ha Neul Lee  ;  Hoon-Chul Kang  ;  Joon Soo Lee  ;  Heung Dong Kim  ;  Ha Young Shin  ;  Seung Min Kim  ;  Il Nam Sunwoo  ;  Young-Mock Lee 
Citation
 Journal of Child Neurology, Vol.31(14) : 1561-1568, 2016 
Journal Title
 Journal of Child Neurology 
ISSN
 0883-0738 
Issue Date
2016
Abstract
Juvenile myasthenia gravis presents before 18 years of age with different characteristics according to racial background and pubertal development. The authors aimed to determine the clinical characteristics of children and adolescents of Korean ethnicity with myasthenia gravis, and evaluate the presentation and clinical outcomes according to the sex and onset age of the patients. The authors recruited 88 Korean juvenile myasthenia gravis patients between September 2005 and August 2015. Worse clinical severity from presentation, more aggressive treatment strategies, and worse final treatment outcomes were noted in girls with postpubertal onset than in the other patients. The symptoms were milder (pure ocular presentation in 96.6% [85/88]) and the disease course was more benign (94.3% [83/88]) in this study than in the literature. The homogenous racial background might have contributed to these results. These findings highlight the influence of pubertal development and the need for timely and appropriate active treatment, including thymectomy, to improve prognosis.
Full Text
http://journals.sagepub.com/doi/abs/10.1177/0883073816666206
DOI
10.1177/0883073816666206
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아청소년과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers
Yonsei Authors
강훈철(Kang, Hoon Chul) ORCID logo https://orcid.org/0000-0002-3659-8847
김승민(Kim, Seung Min) ORCID logo https://orcid.org/0000-0002-4384-9640
김흥동(Kim, Heung Dong) ORCID logo https://orcid.org/0000-0002-8031-7336
신하영(Shin, Ha Young) ORCID logo https://orcid.org/0000-0002-4408-8265
이영목(Lee, Young Mock) ORCID logo https://orcid.org/0000-0002-5838-249X
이준수(Lee, Joon Soo) ORCID logo https://orcid.org/0000-0001-9036-9343
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/152676
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