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Association of Specific Immunoglobulin E to Staphylococcal Enterotoxin with Airway Hyperresponsiveness in Asthma Patients

Authors
 Seong Han Kim  ;  Seo Yeon Yang  ;  Jihong You  ;  Sang Bae Lee  ;  Jin You  ;  Yoon Soo Chang  ;  Hyung Jung Kim  ;  Chul Min Ahn  ;  Min Kwang Byun  ;  Hye Jung Park  ;  Jung-Won Park 
Citation
 TUBERCULOSIS AND RESPIRATORY DISEASES, Vol.79(4) : 295-301, 2016 
Journal Title
TUBERCULOSIS AND RESPIRATORY DISEASES
ISSN
 1738-3536 
Issue Date
2016
Abstract
Background : Specific immunoglobulin E (IgE) sensitization to staphylococcal enterotoxin (SE) has been recently considered to be related to allergic disease, including asthma. Despite studies on specific IgE (sIgE) to SE and its relationship to asthma diagnosis and severity, the association of sIgE to SE with airway hyperresponsiveness (AHR) remains unclear.

Methods : We enrolled 81 asthma patients admitted to the Severance Hospital in Korea from March 1, 2013, to February 28, 2015 and retrospectively reviewed the electronic medical records of the enrolled subjects. The serum levels of sIgE to SE (A/B) of all subjects was measured using the ImmunoCAP 250 (Phadia) system with SE-sIgE positive defined as >0.10 kU/mL.

Results : The SE-sIgE level was not significantly correlated with asthma severity (forced expiratory volume in 1 second [FEV1], FEV1/forced vital capacity, sputum eosinophils, and serum eosinophils), whereas the SE-sIgE level in patients with positive AHR (mean±standard error of the mean, 0.606±0.273 kU/mL) was significantly higher than that in patients with negative AHR (0.062±0.015 kU/mL, p=0.034). In regression analysis, SE sensitization (sIgE to SE ≥0.010 kU/mL) was a significant risk factor for AHR, after adjustment for age, sex, FEV1, and sputum eosinophils (odds ratio, 7.090; 95% confidence interval, 1.180?42.600; p=0.032). Prevalence of SE sensitization was higher in patients with allergic rhinitis and non-atopic asthma patients, as compared to patients without allergic rhinitis and atopic asthma patients, respectively, but without statistical significance.

Conclusion : SE sensitization is significantly associated with AHR.
Files in This Item:
T201605025.pdf Download
DOI
10.4046/trd.2016.79.4.295
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Seong Han(김성한)
Kim, Hyung Jung(김형중) ORCID logo https://orcid.org/0000-0003-2498-0683
Park, Jung Won(박중원) ORCID logo https://orcid.org/0000-0003-0249-8749
Park, Hye Jung(박혜정) ORCID logo https://orcid.org/0000-0002-1862-1003
Byun, Min Kwang(변민광) ORCID logo https://orcid.org/0000-0003-1525-1745
Ahn, Chul Min(안철민)
Yang, Seo Yeon(양서연)
You, Ji Hong(유지홍)
Lee, Sang Bae(이상배) ORCID logo https://orcid.org/0000-0002-2998-6534
Chang, Yoon Soo(장윤수) ORCID logo https://orcid.org/0000-0003-3340-4223
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/152644
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