66 120

Cited 2 times in

Association of Specific Immunoglobulin E to Staphylococcal Enterotoxin with Airway Hyperresponsiveness in Asthma Patients

 Seong Han Kim  ;  Seo Yeon Yang  ;  Jihong You  ;  Sang Bae Lee  ;  Jin You  ;  Yoon Soo Chang  ;  Hyung Jung Kim  ;  Chul Min Ahn  ;  Min Kwang Byun  ;  Hye Jung Park  ;  Jung-Won Park 
 Tuberculosis and Respiratory Diseases, Vol.79(4) : 295-301, 2016 
Journal Title
 Tuberculosis and Respiratory Diseases 
Issue Date
Background : Specific immunoglobulin E (IgE) sensitization to staphylococcal enterotoxin (SE) has been recently considered to be related to allergic disease, including asthma. Despite studies on specific IgE (sIgE) to SE and its relationship to asthma diagnosis and severity, the association of sIgE to SE with airway hyperresponsiveness (AHR) remains unclear. Methods : We enrolled 81 asthma patients admitted to the Severance Hospital in Korea from March 1, 2013, to February 28, 2015 and retrospectively reviewed the electronic medical records of the enrolled subjects. The serum levels of sIgE to SE (A/B) of all subjects was measured using the ImmunoCAP 250 (Phadia) system with SE-sIgE positive defined as >0.10 kU/mL. Results : The SE-sIgE level was not significantly correlated with asthma severity (forced expiratory volume in 1 second [FEV1], FEV1/forced vital capacity, sputum eosinophils, and serum eosinophils), whereas the SE-sIgE level in patients with positive AHR (mean±standard error of the mean, 0.606±0.273 kU/mL) was significantly higher than that in patients with negative AHR (0.062±0.015 kU/mL, p=0.034). In regression analysis, SE sensitization (sIgE to SE ≥0.010 kU/mL) was a significant risk factor for AHR, after adjustment for age, sex, FEV1, and sputum eosinophils (odds ratio, 7.090; 95% confidence interval, 1.180?42.600; p=0.032). Prevalence of SE sensitization was higher in patients with allergic rhinitis and non-atopic asthma patients, as compared to patients without allergic rhinitis and atopic asthma patients, respectively, but without statistical significance. Conclusion : SE sensitization is significantly associated with AHR.
Files in This Item:
T201605025.pdf Download
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
김성한(Kim, Seong Han)
김형중(Kim, Hyung Jung) ORCID logo https://orcid.org/0000-0003-2498-0683
박중원(Park, Jung Won) ORCID logo https://orcid.org/0000-0003-0249-8749
박혜정(Park, Hye Jung) ORCID logo https://orcid.org/0000-0002-1862-1003
변민광(Byun, Min Kwang) ORCID logo https://orcid.org/0000-0003-1525-1745
안철민(Ahn, Chul Min)
양서연(Yang, Seo Yeon)
유지홍(You, Ji Hong)
이상배(Lee, Sang Bae) ORCID logo https://orcid.org/0000-0002-2998-6534
장윤수(Chang, Yoon Soo) ORCID logo https://orcid.org/0000-0003-3340-4223
RIS (EndNote)
XLS (Excel)
사서에게 알리기


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.