Cited 5 times in
Efficacy and Toxicity of Mammalian Target Rapamycin Inhibitors in Patients with Metastatic Renal Cell Carcinoma with Renal Insufficiency: The Korean Cancer Study Group GU 14-08
DC Field | Value | Language |
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dc.contributor.author | 김주훈 | - |
dc.contributor.author | 김지형 | - |
dc.contributor.author | 김효송 | - |
dc.contributor.author | 라선영 | - |
dc.contributor.author | 허수진 | - |
dc.date.accessioned | 2017-10-26T07:52:28Z | - |
dc.date.available | 2017-10-26T07:52:28Z | - |
dc.date.issued | 2016 | - |
dc.identifier.issn | 1598-2998 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/152630 | - |
dc.description.abstract | PURPOSE: We evaluated the efficacy and toxicity of mammalian target rapamycin inhibitors in Korean patients with metastatic renal cell carcinoma (mRCC) with chronic renal insufficiency not requiring dialysis. MATERIALS AND METHODS: Korean patients with mRCC and chronic renal insufficiency not requiring dialysis treated with everolimus or temsirolimus between January 2008 and December 2014 were included. Patient characteristics, clinical outcomes, and toxicities were evaluated. Overall survival (OS) and progression-free survival (PFS) durations were evaluated according to the degree of renal impairment. RESULTS: Eighteen patients were considered eligible for the study (median age, 59 years). The median glomerular filtration rate was 51.5 mL/min/1.73 m2. The best response was partial response in six patients and stable disease in 11 patients. The median PFS and OS durations were 8 months (95% confidence interval [CI], 0 to 20.4) and 32 months (95% CI, 27.5 to 36.5), respectively. The most common non-hematologic and grade 3/4 adverse events included stomatitis, fatigue, flu-like symptoms, and anorexia as well as elevated creatinine level. CONCLUSION: Mammalian target rapamycin inhibitors were efficacious and did not increase toxicity in Korean patients with mRCC and chronic renal insufficiency not requiring dialysis. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English, Korean | - |
dc.publisher | Official journal of Korean Cancer Association | - |
dc.relation.isPartOf | CANCER RESEARCH AND TREATMENT | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Efficacy and Toxicity of Mammalian Target Rapamycin Inhibitors in Patients with Metastatic Renal Cell Carcinoma with Renal Insufficiency: The Korean Cancer Study Group GU 14-08 | - |
dc.type | Article | - |
dc.publisher.location | Korea | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Internal Medicine | - |
dc.contributor.googleauthor | Ki Hyang Kim | - |
dc.contributor.googleauthor | Joo Hoon Kim | - |
dc.contributor.googleauthor | Ji Young Lee | - |
dc.contributor.googleauthor | Hyo Song Kim | - |
dc.contributor.googleauthor | Su Jin Heo | - |
dc.contributor.googleauthor | Ji Hyung Kim | - |
dc.contributor.googleauthor | Ho Young Kim | - |
dc.contributor.googleauthor | Sun Young Rha | - |
dc.identifier.doi | 10.4143/crt.2016.018 | - |
dc.contributor.localId | A00999 | - |
dc.contributor.localId | A01202 | - |
dc.contributor.localId | A01316 | - |
dc.contributor.localId | A04355 | - |
dc.contributor.localId | A00949 | - |
dc.relation.journalcode | J00453 | - |
dc.identifier.eissn | 2005-9256 | - |
dc.relation.journalsince | 2001~ | - |
dc.identifier.pmid | 26875195 | - |
dc.relation.journalbefore | ~2001 Journal of the Korean Cancer Research Association (대한암학회지) | - |
dc.contributor.alternativeName | Kim, Joo Hoon | - |
dc.contributor.alternativeName | Kim, Jee Hung | - |
dc.contributor.alternativeName | Kim, Hyo Song | - |
dc.contributor.alternativeName | Rha, Sun Young | - |
dc.contributor.alternativeName | Heo, Su Jin | - |
dc.contributor.affiliatedAuthor | Kim, Jee Hung | - |
dc.contributor.affiliatedAuthor | Kim, Hyo Song | - |
dc.contributor.affiliatedAuthor | Rha, Sun Young | - |
dc.contributor.affiliatedAuthor | Heo, Su Jin | - |
dc.contributor.affiliatedAuthor | Kim, Joo Hoon | - |
dc.citation.volume | 48 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 1286 | - |
dc.citation.endPage | 1292 | - |
dc.identifier.bibliographicCitation | CANCER RESEARCH AND TREATMENT, Vol.48(4) : 1286-1292, 2016 | - |
dc.date.modified | 2017-10-24 | - |
dc.identifier.rimsid | 39639 | - |
dc.type.rims | ART | - |
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