148 307

Cited 0 times in

Optimal Treatment Decision for Brain Metastases of Unknown Primary Origin: The Role and Timing of Radiosurgery

DC Field Value Language
dc.contributor.author박용구-
dc.contributor.author장원석-
dc.contributor.author장종희-
dc.contributor.author정현호-
dc.contributor.author한현진-
dc.date.accessioned2017-10-26T07:51:13Z-
dc.date.available2017-10-26T07:51:13Z-
dc.date.issued2016-
dc.identifier.issn2288-2405-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/152594-
dc.description.abstractBACKGROUND: Up to 15% of all patients with brain metastases have no clearly detected primary site despite intensive evaluation, and this incidence has decreased with the use of improved imaging technology. Radiosurgery has been evaluated as one of the treatment modality for patients with limited brain metastases. In this study, we evaluated the effectiveness of radiosurgery for brain metastases from unknown primary tumors. METHODS: We retrospectively evaluated 540 patients who underwent gamma knife radiosurgery (GKRS) for brain metastases radiologically diagnosed between August 1992 and September 2007 in our institution. First, the brain metastases were grouped into metachronous, synchronous, and precocious presentations according to the timing of diagnosis of the brain metastases. Then, synchronous and precocious brain metastases were further grouped into 1) unknown primary; 2) delayed known primary; and 3) synchronous metastases according to the timing of diagnosis of the primary origin. We analyzed the survival time and time to new brain metastasis in each group. RESULTS: Of the 540 patients, 29 (5.4%) presented precocious or synchronous metastases (34 GKRS procedures for 174 lesions). The primary tumor was not found even after intensive and repeated systemic evaluation in 10 patients (unknown primary, 34.5%); found after 8 months in 3 patients (delayed known primary, 1.2%); and diagnosed at the same time as the brain metastases in 16 patients (synchronous metastasis, 55.2%). No statistically significant differences in survival time and time to new brain metastasis were found among the three groups. CONCLUSION: Identification of a primary tumor before GKRS did not affect the patient outcomes. If other possible differential diagnoses were completely excluded, early GKRS can be an effective treatment option for brain metastases from unknown primary tumor.-
dc.description.statementOfResponsibilityopen-
dc.publisherKorean Brain Tumor Society-
dc.relation.isPartOfBrain Tumor Research and Treatment-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleOptimal Treatment Decision for Brain Metastases of Unknown Primary Origin: The Role and Timing of Radiosurgery-
dc.typeArticle-
dc.publisher.locationKorea-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Neurosurgery-
dc.contributor.googleauthorHyun Jin Han-
dc.contributor.googleauthorWon Seok Chang-
dc.contributor.googleauthorHyun Ho Jung-
dc.contributor.googleauthorYong Gou Park-
dc.contributor.googleauthorHae Yu Kim-
dc.contributor.googleauthorJong Hee Chang-
dc.identifier.doi10.14791/btrt.2016.4.2.107-
dc.contributor.localIdA03454-
dc.contributor.localIdA03470-
dc.contributor.localIdA03775-
dc.contributor.localIdA05067-
dc.contributor.localIdA01578-
dc.relation.journalcodeJ00398-
dc.relation.journalsince2013~-
dc.identifier.pmid27867920-
dc.relation.journalbefore~2012 Journal of Korean Brain Tumor Society (대한뇌종양학회지)-
dc.contributor.alternativeNamePark, Yong Gou-
dc.contributor.alternativeNameChang, Won Seok-
dc.contributor.alternativeNameChang, Jong Hee-
dc.contributor.alternativeNameJung, Hyun Ho-
dc.contributor.alternativeNameHan, Hyun Jin-
dc.contributor.affiliatedAuthorChang, Won Seok-
dc.contributor.affiliatedAuthorChang, Jong Hee-
dc.contributor.affiliatedAuthorJung, Hyun Ho-
dc.contributor.affiliatedAuthorHan, Hyun Jin-
dc.contributor.affiliatedAuthorPark, Yong Gou-
dc.citation.volume4-
dc.citation.number2-
dc.citation.startPage107-
dc.citation.endPage110-
dc.identifier.bibliographicCitationBrain Tumor Research and Treatment, Vol.4(2) : 107-110, 2016-
dc.date.modified2017-10-24-
dc.identifier.rimsid39605-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurosurgery (신경외과학교실) > 1. Journal Papers

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.