Cited 12 times in
Association Between Duration of Dual Antiplatelet Therapy and Angiographic Multivessel Disease on Outcomes in Patients Treated With Newer-Generation Drug-Eluting Stents
DC Field | Value | Language |
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dc.contributor.author | 고영국 | - |
dc.contributor.author | 최동훈 | - |
dc.contributor.author | 홍명기 | - |
dc.contributor.author | 김병극 | - |
dc.contributor.author | 김중선 | - |
dc.contributor.author | 신동호 | - |
dc.contributor.author | 장양수 | - |
dc.date.accessioned | 2017-10-26T07:49:53Z | - |
dc.date.available | 2017-10-26T07:49:53Z | - |
dc.date.issued | 2016 | - |
dc.identifier.issn | 1941-7640 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/152563 | - |
dc.description.abstract | BACKGROUND: There is general agreement that the optimal duration of dual antiplatelet therapy (DAPT) in patients treated with drug-eluting stents should be individualized. We hypothesized that the extent of coronary artery disease may affect the clinical outcomes of DAPT. METHODS AND RESULTS: We pooled patient-level data from 5 large, randomized trials comparing short-term DAPT with prolonged therapy. From the data, we identified 5476 patients who received newer-generation drug-eluting stents. Net adverse clinical event (NACE) was defined as a composite of all-cause mortality, myocardial infarction, stroke, or major bleeding. At 1 year, NACE had occurred in 171 patients (3.1%). Independent predictors of NACE were older age (>65 years), sex, presence of diabetes mellitus, left ventricular dysfunction (ejection fraction <40%), and angiographic multivessel disease. Multivessel disease and DAPT duration were significantly associated with NACE (P for interaction=0.002); the association was driven by the greater occurrence of myocardial infarction in patients with multivessel disease. In patients with multivessel disease, 6-month DAPT (versus 12-month DAPT) was associated with a higher incidence of myocardial infarction (adjusted hazard ratio=2.748; 95% confidence interval=1.375-5.491; P=0.004), compared with patients with single-vessel disease (P for interaction=0.001). CONCLUSIONS: In patients treated with newer-generation drug-eluting stents, a significant interaction between DAPT strategy and multivessel disease was found regarding the occurrence of NACE at 1 year. Among adverse events, myocardial infarction was more frequent in 6-month DAPT than in 12-month DAPT in patients with multivessel disease. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Lippincott Williams & Wilkins | - |
dc.relation.isPartOf | CIRCULATION-CARDIOVASCULAR INTERVENTIONS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Coronary Angiography* | - |
dc.subject.MESH | Coronary Artery Disease/diagnostic imaging | - |
dc.subject.MESH | Coronary Artery Disease/mortality | - |
dc.subject.MESH | Coronary Artery Disease/therapy* | - |
dc.subject.MESH | Coronary Vessels/diagnostic imaging* | - |
dc.subject.MESH | Drug Administration Schedule | - |
dc.subject.MESH | Drug Therapy, Combination | - |
dc.subject.MESH | Drug-Eluting Stents* | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Hemorrhage/chemically induced | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Myocardial Infarction/etiology | - |
dc.subject.MESH | Percutaneous Coronary Intervention/adverse effects | - |
dc.subject.MESH | Percutaneous Coronary Intervention/instrumentation* | - |
dc.subject.MESH | Percutaneous Coronary Intervention/mortality | - |
dc.subject.MESH | Platelet Aggregation Inhibitors/administration & dosage* | - |
dc.subject.MESH | Platelet Aggregation Inhibitors/adverse effects | - |
dc.subject.MESH | Predictive Value of Tests | - |
dc.subject.MESH | Prosthesis Design | - |
dc.subject.MESH | Randomized Controlled Trials as Topic | - |
dc.subject.MESH | Risk Assessment | - |
dc.subject.MESH | Risk Factors | - |
dc.subject.MESH | Stroke/etiology | - |
dc.subject.MESH | Time Factors | - |
dc.subject.MESH | Treatment Outcome | - |
dc.title | Association Between Duration of Dual Antiplatelet Therapy and Angiographic Multivessel Disease on Outcomes in Patients Treated With Newer-Generation Drug-Eluting Stents | - |
dc.type | Article | - |
dc.publisher.location | United States | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Internal Medicine | - |
dc.contributor.googleauthor | Seung-Yul Lee | - |
dc.contributor.googleauthor | Myeong-Ki Hong | - |
dc.contributor.googleauthor | Dong-Ho Shin | - |
dc.contributor.googleauthor | Jung-Sun Kim | - |
dc.contributor.googleauthor | Byeong-Keuk Kim | - |
dc.contributor.googleauthor | Young-Guk Ko | - |
dc.contributor.googleauthor | Donghoon Choi | - |
dc.contributor.googleauthor | Yangsoo Jang | - |
dc.contributor.googleauthor | Hyo-Soo Kim | - |
dc.contributor.googleauthor | Marco Valgimigli | - |
dc.contributor.googleauthor | Antonio Colombo | - |
dc.contributor.googleauthor | Martine Gilard | - |
dc.contributor.googleauthor | Tullio Palmerini | - |
dc.contributor.googleauthor | Gregg W. Stone | - |
dc.identifier.doi | 10.1161/CIRCINTERVENTIONS.116.004256 | - |
dc.contributor.localId | A04053 | - |
dc.contributor.localId | A04391 | - |
dc.contributor.localId | A00493 | - |
dc.contributor.localId | A00961 | - |
dc.contributor.localId | A02097 | - |
dc.contributor.localId | A03448 | - |
dc.contributor.localId | A00127 | - |
dc.relation.journalcode | J00539 | - |
dc.identifier.eissn | 1941-7632 | - |
dc.identifier.pmid | 27803041 | - |
dc.identifier.url | http://circinterventions.ahajournals.org/content/9/11/e004256 | - |
dc.subject.keyword | antiplatelet drugs | - |
dc.subject.keyword | coronary artery disease | - |
dc.subject.keyword | drug-eluting stent | - |
dc.contributor.alternativeName | Ko, Young Guk | - |
dc.contributor.alternativeName | Choi, Dong Hoon | - |
dc.contributor.alternativeName | Hong, Myeong Ki | - |
dc.contributor.alternativeName | Kim, Byeong Keuk | - |
dc.contributor.alternativeName | Kim, Jung Sun | - |
dc.contributor.alternativeName | Shin, Dong Ho | - |
dc.contributor.alternativeName | Jang, Yang Soo | - |
dc.contributor.affiliatedAuthor | Choi, Dong Hoon | - |
dc.contributor.affiliatedAuthor | Hong, Myeong Ki | - |
dc.contributor.affiliatedAuthor | Kim, Byeong Keuk | - |
dc.contributor.affiliatedAuthor | Kim, Jung Sun | - |
dc.contributor.affiliatedAuthor | Shin, Dong Ho | - |
dc.contributor.affiliatedAuthor | Jang, Yang Soo | - |
dc.contributor.affiliatedAuthor | Ko, Young Guk | - |
dc.citation.volume | 9 | - |
dc.citation.number | 11 | - |
dc.citation.startPage | 004256 | - |
dc.identifier.bibliographicCitation | CIRCULATION-CARDIOVASCULAR INTERVENTIONS, Vol.9(11) : 004256, 2016 | - |
dc.date.modified | 2017-10-24 | - |
dc.identifier.rimsid | 48765 | - |
dc.type.rims | ART | - |
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