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Success of tumorsphere isolation from WHO grade IV gliomas does not correlate with the weight of fresh tumor specimens: an immunohistochemical characterization of tumorsphere differentiation

Authors
 Kyoung Su Sung  ;  Jin-Kyoung Shim  ;  Ji-Hyun Lee  ;  Se Hoon Kim  ;  Sohee Park  ;  Tae-Hoon Roh  ;  Ju Hyung Moon  ;  Eui-Hyun Kim  ;  Sun Ho Kim  ;  Su Jae Lee  ;  Yong Min Huh  ;  Seok-Gu Kang  ;  Jong Hee Chang 
Citation
 Cancer Cell International, Vol.16 : 75-75, 2016 
Journal Title
 Cancer Cell International 
Issue Date
2016
Keywords
Fresh specimen ; Isolation ; Tumorsphere ; WHO grade IV glioma ; Weight
Abstract
BACKGROUND: A trend of stage-by-stage increase in tumorsphere (TS) formation from glioma samples has been reported. Despite this trend, not all surgical specimens give rise to TSs, even World Health Organization (WHO) grade IV gliomas. Furthermore, it has been reported that differences in overall survival of primary glioblastoma patients depends on the propensity of their tumors to form TSs. However, the weights of fresh specimens vary from one surgical isolate to the next. METHODS: Accordingly, we evaluated the relationship between the weights of surgical specimens in WHO grade IV gliomas with the capacity to isolate TSs. Thirty-five fresh WHO grade IV glioma specimens were separated into two groups, based on whether they were positive or negative for TS isolation, and the relationship between TS isolation and weight of surgical specimens was assessed. RESULTS: We observed no significant difference in the weights of surgical samples in the two groups, and found that the optimal weight of specimens for TSs isolation was 500 mg. CONCLUSION: Thus, contrary to our expectations, the ability to isolate TSs from WHO grade IV glioma specimens was not related to the weight of fresh specimens.
Files in This Item:
T201604532.pdf Download
DOI
10.1186/s12935-016-0350-1
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurosurgery (신경외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
4. Graduate School of Public Health (보건대학원) > Graduate School of Public Health (보건대학원) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
Yonsei Authors
강석구(Kang, Seok Gu) ORCID logo https://orcid.org/0000-0001-5676-2037
김선호(Kim, Sun Ho) ORCID logo https://orcid.org/0000-0003-0970-3848
김세훈(Kim, Se Hoon) ORCID logo https://orcid.org/0000-0001-7516-7372
김의현(Kim, Eui Hyun) ORCID logo https://orcid.org/0000-0002-2523-7122
노태훈(Roh, Tae Hoon)
박소희(Park, So Hee) ORCID logo https://orcid.org/0000-0001-8513-5163
이지현(Lee, Ji Hyun) ORCID logo https://orcid.org/0000-0002-9223-9478
장종희(Chang, Jong Hee)
허용민(Huh, Yong Min) ORCID logo https://orcid.org/0000-0002-9831-4475
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/152559
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