Cited 16 times in
Expression of CAF-Related Proteins Is Associated with Histologic Grade of Breast Phyllodes Tumor
DC Field | Value | Language |
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dc.contributor.author | 구자승 | - |
dc.contributor.author | 김혜민 | - |
dc.contributor.author | 이유경 | - |
dc.date.accessioned | 2017-10-26T07:49:31Z | - |
dc.date.available | 2017-10-26T07:49:31Z | - |
dc.date.issued | 2016 | - |
dc.identifier.issn | 0278-0240 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/152557 | - |
dc.description.abstract | Purpose. The purpose of this study was to investigate the expression of cancer-associated fibroblast- (CAF-) related proteins and the implications in breast phyllodes tumor (PT). Methods. Tissue microarrays of 194 PT cases (151 benign PT, 27 borderline PT, and 16 malignant PT) were constructed. We performed immunohistochemical staining for CAF-related proteins (podoplanin, prolyl 4-hydroxylase, FAPα, S100A4, PDGFR α/β, and NG2) and analyzed the results according to clinicopathologic parameters. Results. Expression of PDGFRα and PDGFRβ in the stromal component increased with increasing histologic grade of PT (p = 0.003 and p = 0.034, resp.). Among clinicopathologic parameters, only expression of FAPα in stroma was associated with distant metastasis (p = 0.002). In univariate analysis, stromal expression of PDGFRα was associated with shorter overall survival (p = 0.002). In Cox multivariate analysis, stromal overgrowth and PDGFRα stromal positivity were associated with shorter overall survival (p = 0.006 and p = 0.050, resp.). Furthermore, expression of PDGFRβ in stroma was associated with shorter overall survival in patients with malignant PT (p = 0.041). Conclusion. Stromal expression of PDGFRα and PDGFRβ increased with increasing histologic grade of PT. In addition, PDGFR stromal positivity was associated with shorter overall survival. These results suggest that CAFs are associated with breast PT progression. | - |
dc.description.statementOfResponsibility | open | - |
dc.format | application/octet-stream | - |
dc.language | English | - |
dc.publisher | Hindawi Pub. Corp. | - |
dc.relation.isPartOf | DISEASE MARKERS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Biomarkers, Tumor/genetics | - |
dc.subject.MESH | Biomarkers, Tumor/metabolism* | - |
dc.subject.MESH | Breast Neoplasms/genetics | - |
dc.subject.MESH | Breast Neoplasms/metabolism* | - |
dc.subject.MESH | Breast Neoplasms/pathology | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Gelatinases/genetics | - |
dc.subject.MESH | Gelatinases/metabolism* | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Membrane Proteins/genetics | - |
dc.subject.MESH | Membrane Proteins/metabolism* | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Neoplasm Metastasis | - |
dc.subject.MESH | Phyllodes Tumor/genetics | - |
dc.subject.MESH | Phyllodes Tumor/metabolism* | - |
dc.subject.MESH | Phyllodes Tumor/pathology | - |
dc.subject.MESH | Receptor, Platelet-Derived Growth Factor alpha/genetics | - |
dc.subject.MESH | Receptor, Platelet-Derived Growth Factor alpha/metabolism* | - |
dc.subject.MESH | Receptor, Platelet-Derived Growth Factor beta/genetics | - |
dc.subject.MESH | Receptor, Platelet-Derived Growth Factor beta/metabolism* | - |
dc.subject.MESH | Serine Endopeptidases/genetics | - |
dc.subject.MESH | Serine Endopeptidases/metabolism* | - |
dc.subject.MESH | Stromal Cells/metabolism | - |
dc.subject.MESH | Stromal Cells/pathology | - |
dc.title | Expression of CAF-Related Proteins Is Associated with Histologic Grade of Breast Phyllodes Tumor | - |
dc.type | Article | - |
dc.publisher.location | United States | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Pathology | - |
dc.contributor.googleauthor | HyeMin Kim | - |
dc.contributor.googleauthor | Yu Kyung Lee | - |
dc.contributor.googleauthor | Ja Seung Koo | - |
dc.identifier.doi | 10.1155/2016/4218989 | - |
dc.contributor.localId | A04553 | - |
dc.contributor.localId | A03010 | - |
dc.contributor.localId | A00198 | - |
dc.relation.journalcode | J00743 | - |
dc.identifier.eissn | 1875-8630 | - |
dc.identifier.pmid | 27881889 | - |
dc.contributor.alternativeName | Koo, Ja Seung | - |
dc.contributor.alternativeName | Kim, Hye Min | - |
dc.contributor.alternativeName | Lee, Yu Kyung | - |
dc.contributor.affiliatedAuthor | Kim, Hye Min | - |
dc.contributor.affiliatedAuthor | Lee, Yu Kyung | - |
dc.contributor.affiliatedAuthor | Koo, Ja Seung | - |
dc.contributor.affiliatedAuthor | 구자승 | - |
dc.citation.volume | 2016 | - |
dc.citation.startPage | 4218989 | - |
dc.identifier.bibliographicCitation | DISEASE MARKERS, Vol.2016 : 4218989, 2016 | - |
dc.date.modified | 2017-10-24 | - |
dc.identifier.rimsid | 48759 | - |
dc.type.rims | ART | - |
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