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Physical and Mechanical Modifications of Collagen Microfibers Using Ethanol-Based Dehydrating Conditions

Authors
 Seon Young Bak  ;  Sang Woo Lee  ;  Kyung Sik Kim  ;  Hyun Woo Kim 
Citation
 Macromolecular Materials and Engineering, Vol.301(11) : 1307-1312, 2016 
Journal Title
 Macromolecular Materials and Engineering 
ISSN
 1438-7492 
Issue Date
2016
Keywords
cell attachment ; collagen microfiber ; ethanol ; mechanical properties ; physical characteristics
Abstract
This study describes novel and simple conditions for the fabrication of collagen microfibers with specific physical and mechanical properties, which can then be potentially applied as cell-based matrices. The microfibers are fabricated from collagen hydrogels, using various concentrations of ethanol, in ethanol?water solvents. At higher ethanol concentration, fibers exhibited increased uniformity of surface morphology, decreased diameter, and increased tensile strength. The morphology of cells on microfibers varies due to the surface morphology of microfibers but the microfibers fabricated under all conditions investigated show similar number of attached cells on the surface of fibers, and cells sustain their viability for 90 h.
Full Text
http://onlinelibrary.wiley.com/doi/10.1002/mame.201600119/abstract
DOI
10.1002/mame.201600119
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Orthopedic Surgery (정형외과학교실) > 1. Journal Papers
Yonsei Authors
김경식(Kim, Kyung Sik) ORCID logo https://orcid.org/0000-0001-9498-284X
김현우(Kim, Hyun Woo) ORCID logo https://orcid.org/0000-0001-8576-1877
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/152541
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