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Z-score discordance and contributing factors in healthy premenopausal women with low bone mineral density: the Korean National Health and Nutrition Examination Survey 2008-9

DC FieldValueLanguage
dc.contributor.author이유미-
dc.contributor.author임승길-
dc.date.accessioned2017-10-26T07:48:38Z-
dc.date.available2017-10-26T07:48:38Z-
dc.date.issued2016-
dc.identifier.issn0914-8779-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/152536-
dc.description.abstractThe premenopausal period is important for bone health and prevention of future fractures, but measuring bone mineral density (BMD) at only one site may not be sufficient to determine therapeutic strategies for low BMD in premenopausal women due to the presence of Z-score discordance. In this study, we investigated Z-score discordance in addition to contributing factors of idiopathic low BMD in healthy premenopausal Korean women. We studied 3003 premenopausal women aged 18-50 years, without secondary causes for low BMD and history of fragility fracture, who had participated in the Fourth Korean National Health and Nutrition Examination Surveys (2008-2009). Low body mass index (BMI), low vitamin D level, and low body muscle mass were associated with low BMD even in premenopausal women. Risk factors differed depending on the anatomic site. Low BMI and low vitamin D level were risk factors for low femoral neck BMD (FN-BMD), but not for low lumbar spine BMD (LS-BMD). Only total muscle mass had a slight effect on low LS-BMD. Z-score discordance was much higher than expected, in 75 and 73.8 % of the low LS-BMD and low FN-BMD groups, respectively. Our findings suggest the need to consider BMD discordance in premenopausal women and also to provide information on correctable factors affecting low BMD in younger populations. Long-term follow-up is needed to evaluate the possible effect of Z-score discordance on the prognosis of osteoporosis and subsequent fracture risk.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherJapanese Society of Bone and Mineral Metabolism-
dc.relation.isPartOfJournal of Bone and Mineral Metabolism-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdolescent-
dc.subject.MESHAdult-
dc.subject.MESHBody Mass Index*-
dc.subject.MESHBone Density*-
dc.subject.MESHFemale-
dc.subject.MESHFractures, Bone/epidemiology-
dc.subject.MESHFractures, Bone/etiology-
dc.subject.MESHFractures, Bone/metabolism*-
dc.subject.MESHHumans-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHNutrition Surveys-
dc.subject.MESHOsteoporosis/complications-
dc.subject.MESHOsteoporosis/epidemiology-
dc.subject.MESHOsteoporosis/metabolism*-
dc.subject.MESHPostmenopause/metabolism-
dc.subject.MESHRepublic of Korea/epidemiology-
dc.subject.MESHRisk Factors-
dc.titleZ-score discordance and contributing factors in healthy premenopausal women with low bone mineral density: the Korean National Health and Nutrition Examination Survey 2008-9-
dc.typeArticle-
dc.publisher.locationJapan-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Internal Medicine-
dc.contributor.googleauthorKyeong Hye Park-
dc.contributor.googleauthorJung Soo Lim-
dc.contributor.googleauthorKyoung Min Kim-
dc.contributor.googleauthorYumie Rhee-
dc.contributor.googleauthorSung-Kil Lim-
dc.identifier.doi10.1007/s00774-015-0715-x-
dc.contributor.localIdA03375-
dc.contributor.localIdA03012-
dc.relation.journalcodeJ01277-
dc.identifier.pmid26445825-
dc.identifier.urlhttps://link.springer.com/article/10.1007%2Fs00774-015-0715-x-
dc.subject.keywordDiscordance-
dc.subject.keywordLow bone mineral density-
dc.subject.keywordPremenopausal women-
dc.subject.keywordZ-score-
dc.contributor.alternativeNameRhee, Yumie-
dc.contributor.alternativeNameLim, Sung Kil-
dc.contributor.affiliatedAuthorLim, Sung Kil-
dc.contributor.affiliatedAuthorRhee, Yumie-
dc.citation.volume34-
dc.citation.number6-
dc.citation.startPage668-
dc.citation.endPage677-
dc.identifier.bibliographicCitationJournal of Bone and Mineral Metabolism, Vol.34(6) : 668-677, 2016-
dc.date.modified2017-10-24-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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